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Study of PF-07263689 in Participants With Selected Advanced Solid Tumors

ABSTRACT: This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and expansion study intended to evaluate the safety, viral load kinetics and shedding, pharmacodynamic, and anti-tumor activity of PF-07263689, either alone or in combination with sasanlimab (an investigational anti-programmed cell death protein 1 [PD-1] antibody), in patients with selected locally advanced or metastatic solid tumors who have exhausted all available standard of care therapies available to them. The study consists of 2 parts: Part 1 dose escalation for PF-07263689 monotherapy (Part 1A) and in combination with sasanlimab (Part 1B), followed by Part 2 dose expansion for the combination therapy.

DISEASE(S): Sarcoma,Melanoma,Colorectal Cancer,Bladder Cancer,Liver Neoplasms,Ovarian Cancer,Squamous Cell Carcinoma,Carcinoma, Renal Cell,Head And Neck Cancer,Non-small-cell Lung Cancer,Hepatocellular Cancer,Carcinoma, Hepatocellular,Renal Cell Cancer

PROVIDER: 2390967 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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