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Transverse Abdominus Plane Block Study

ABSTRACT: Study the effect of laparoscopic guided TAP block on opioid consumption and associated costs using a mixture of dexmedetomidine, dexamethasone, and ropivacaine versus Liposomal bupivacaine (Exparel) in patients who undergo elective minimally invasive colorectal surgery.

DISEASE(S): Colorectal Disorders

PROVIDER: 2402852 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel)

Project description:Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the post-operative analgesic window and limit opioid use. A new liposomal-depo formulation of bupivacaine (Exparel) has gained popularity as a long-lasting TAP block medication, but has not been studied in a well-powered clinical trial specifically in colorectal patients nor compared to a bupivacaine/steroid mixture which may offer similar effects. We conduct a prospective randomized prospective randomized study of patients undergoing major laparoscopic colorectal surgery to compare the analgesic effects of a bupivacaine/steroid mixture versus liposomal bupivacaine.

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Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

Project description:Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia. The aim of this study is to detect whether the Erector spinae plan block or Quadratus lumborum block will provide the most ideal analgesia for these patients. Erector spinae plan block is a novel analgesic technique that provides both visceral and somatic analgesia due to its communication with the paravertebral space. Quadratus lumborum block is a truncal nerve block usually used for intra-abdominal surgeries. Ultrasound guidance increases the accuracy and safety of both techniques. A local anaesthetic mixture of Bupivacaine 0.25% and dexamethasone will be used for both techniques.

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Effects of quaratus lumborum block versus transversus abdominis plane block on enhanced recovery after laparoscopic radical resection of colorectal cancer : A prospective randomized controlled study

Project description:Interventions: QL:Bilateral quaratus lumborum block with 0.375% ropivacaine 20ml;TAP:Bilateral transversus abdominis plane block with 0.375% ropivacaine 20ml Primary outcome(s): Visual analogue pain scale (VAS);intraoperative remifentanil consumption Study Design: Randomized parallel controlled trial

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Quadratus lumborum block versus transverse abdominal plane block for pain control after laparoscopic radical resection of colorectal cancer: a prospective, double-blind, randomized, controlled trial

Project description:Interventions: LQB group:local injection of ropivacaine;TAPB group:local injection of ropivacaine Primary outcome(s): The activity and rest pain visual analogue (VAS) scores;the use of analgesics during operation;observations of vital signs Study Design: Parallel

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Transversus Abdominis Plane Blocks With and Without Dexamethasone

Project description:Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.

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The Safety of Ropivacaine TAP Block Combined With Intravenous Lidocaine in Patients Undergoing Colorectal Cancer Surgery

Project description:Many studies have confirmed the analgesic effect of intravenous infusion of lidocaine in abdominal surgery. Transversus abdominis plane (TAP) block is also often recommended for abdominal surgery. Ropivacaine TAP block and intravenous lidocaine infusion are important components of multimodal analgesia for colorectal surgery. However, both of them are the local anesthetics and the safety of combination is unknown, so we design the study to explore the safety of the synergistic application of ropivacaine TAP block and intravenous lidocaine infusion in patients undergoing colorectal surgery.

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Effect of Intravenous or Perineural Dexmedetomidine and Dexamethasone for Quadratus Lumborum Block on the Quality of Recovery Following Laparoscopic Radical Colorectal Cancer Surgery

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Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit

Project description:The Transversus Abdominis Block (TAP) block is known to be an effective means of reducing patient pain after abdominal surgery. In the meantime, the general TAP block has been studied in patients who were in the recovery room and the ward after surgery. The purpose of this study was to determine the effect of pain reduction and opioid saving effects in patients with TAP block in ICU settings.

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Comparison of ultrasound-guided erector spinae plane block and transversus abdominis plane block in postoperative analgesia of laparoscopic colorectal cancer surgery

Project description:Interventions: TAP:Transversus abdominis plane block;ESP:Erector spinae plane block Primary outcome(s): Visual Analogue Scale Study Design: Randomized parallel controlled trial

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Comparison of Ultrasound-Guided Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block for Postoperative Analgesia in Elderly Patients After Laparoscopic Colorectal Surgery: A Prospective Randomized Study.

Project description:IntroductionPostoperative analgesia in elderly patients is still a thorny problem. Ultrasound-guided oblique subcostal transverse abdominis plane block (TAPB) has been demonstrated to provide postoperative analgesia after abdominal surgeries. However, recent studies have suggested that an alternative method, erector spinae plane block (ESPB), might also be effective. In this study, we compared the postoperative analgesic effects of ESPB and TAPB in elderly patients who had undergone laparoscopic colorectal surgery.MethodsSixty-two elderly patients (≥ 65 years old) scheduled for elective laparoscopic colorectal surgery with general anesthesia were randomly allocated to two equally sized groups: ESPB group and TAPB group. The ESPB group had a bilateral erector spinae plane block, and the TAPB group had a bilateral oblique subcostal transverse abdominis plane block. The primary outcome was visual analogue scale (VAS) pain score during the first 24 postoperative hours at resting and active states. The secondary outcomes were postoperative consumption of sufentanil, satisfaction score, the number of patients who required antiemetics, incidence of block-related complications, and other side events.ResultsThere were no demographic differences between two groups. Compared to the TAPB group, the ESPB group had lower VAS pain scores and sufentanil consumption during the first 24 postoperative hours. Additionally, ESPB reduced the occurrence of postoperative nausea and vomiting. Furthermore, the satisfaction score was higher in the ESPB group. No other complications were reported between the two groups.ConclusionsCompared with oblique subcostal TAPB, ESPB more effectively reduced postoperative pain and opioid consumption. Thus, ESPB is suitable for postoperative analgesia in elderly patients who have undergone laparoscopic colorectal surgery.Trial registrationChinese Clinical Trial Registry: ChiCTR2000033236.

| S-EPMC8586115 | biostudies-literature

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