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Transverse Abdominus Plane Block Study

ABSTRACT: Study the effect of laparoscopic guided TAP block on opioid consumption and associated costs using a mixture of dexmedetomidine, dexamethasone, and ropivacaine versus Liposomal bupivacaine (Exparel) in patients who undergo elective minimally invasive colorectal surgery.

DISEASE(S): Colorectal Disorders

PROVIDER: 2402852 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel)

Project description:Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the post-operative analgesic window and limit opioid use. A new liposomal-depo formulation of bupivacaine (Exparel) has gained popularity as a long-lasting TAP block medication, but has not been studied in a well-powered clinical trial specifically in colorectal patients nor compared to a bupivacaine/steroid mixture which may offer similar effects. We conduct a prospective randomized prospective randomized study of patients undergoing major laparoscopic colorectal surgery to compare the analgesic effects of a bupivacaine/steroid mixture versus liposomal bupivacaine.

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Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

Project description:Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia. The aim of this study is to detect whether the Erector spinae plan block or Quadratus lumborum block will provide the most ideal analgesia for these patients. Erector spinae plan block is a novel analgesic technique that provides both visceral and somatic analgesia due to its communication with the paravertebral space. Quadratus lumborum block is a truncal nerve block usually used for intra-abdominal surgeries. Ultrasound guidance increases the accuracy and safety of both techniques. A local anaesthetic mixture of Bupivacaine 0.25% and dexamethasone will be used for both techniques.

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Effects of quaratus lumborum block versus transversus abdominis plane block on enhanced recovery after laparoscopic radical resection of colorectal cancer : A prospective randomized controlled study

Project description:Interventions: QL:Bilateral quaratus lumborum block with 0.375% ropivacaine 20ml;TAP:Bilateral transversus abdominis plane block with 0.375% ropivacaine 20ml Primary outcome(s): Visual analogue pain scale (VAS);intraoperative remifentanil consumption Study Design: Randomized parallel controlled trial

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Quadratus lumborum block versus transverse abdominal plane block for pain control after laparoscopic radical resection of colorectal cancer: a prospective, double-blind, randomized, controlled trial

Project description:Interventions: LQB group:local injection of ropivacaine;TAPB group:local injection of ropivacaine Primary outcome(s): The activity and rest pain visual analogue (VAS) scores;the use of analgesics during operation;observations of vital signs Study Design: Parallel

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Transversus Abdominis Plane Blocks With and Without Dexamethasone

Project description:Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.

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The Safety of Ropivacaine TAP Block Combined With Intravenous Lidocaine in Patients Undergoing Colorectal Cancer Surgery

Project description:Many studies have confirmed the analgesic effect of intravenous infusion of lidocaine in abdominal surgery. Transversus abdominis plane (TAP) block is also often recommended for abdominal surgery. Ropivacaine TAP block and intravenous lidocaine infusion are important components of multimodal analgesia for colorectal surgery. However, both of them are the local anesthetics and the safety of combination is unknown, so we design the study to explore the safety of the synergistic application of ropivacaine TAP block and intravenous lidocaine infusion in patients undergoing colorectal surgery.

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Effect of Intravenous or Perineural Dexmedetomidine and Dexamethasone for Quadratus Lumborum Block on the Quality of Recovery Following Laparoscopic Radical Colorectal Cancer Surgery

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Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit

Project description:The Transversus Abdominis Block (TAP) block is known to be an effective means of reducing patient pain after abdominal surgery. In the meantime, the general TAP block has been studied in patients who were in the recovery room and the ward after surgery. The purpose of this study was to determine the effect of pain reduction and opioid saving effects in patients with TAP block in ICU settings.

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Analgesic Efficacy of Transverse Abdominis Plane Block and Quadratus Lumborum Block in Laparoscopic Sleeve Gastrectomy: A Randomized Double-Blinded Clinical Trial.

Project description:IntroductionThe analgesic effect and safety of transversus abdominis plane block (TAPB) is still controversial in various abdominal procedures. Quadratus lumborum block (QLB) has been considered to provide a widespread and long-lasting analgesic effect in gynecological surgeries. However, the analgesic effects of these two techniques in patients with extreme obesity undergoing laparoscopic sleeve gastrectomy (LSG) are still unknown.MethodsA total of 225 patients with obesity were randomly assigned to group TAPB (n = 76, 30 ml 0.33% ropivacaine with dexmedetomidine 1 μg kg-1), group QLB (n = 76, 30 ml 0.33% ropivacaine with dexmedetomidine 1 μg kg-1), or general anesthesia alone (GA, n = 73, 30 ml 0.9% saline). During the 48-h postoperative period, patients received continuous intravenous patient-controlled analgesia (PCA) containing sufentanil 2 μg kg-1, dexmedetomidine 2 μg kg-1, and granisetron 3 mg. The scores of visual analogue scale (VAS) in surgical incision and viscera, considering as the primary outcomes, were continuously recorded at postoperative 0, 0.5, 1, 2, 6, 12, 24, 48 h and discharge.ResultsComparing with patients in the GA group, VAS scores of incision and viscera were consistently reduced during the initial 6-12 h after LSG in TAPB and QLB groups, and they received less propofol and remifentanil (P < 0.001) as well. In the QLB group, patients had longer duration for the first rescue analgesia, and fewer requirements of the rescue analgesia within 24 h than the GA group (P < 0.05). In addition, there were fewer PCA requirements in QLB group than GA and TAPB groups (P < 0.05).ConclusionsUltrasound-guided transversus abdominis plane block and quadratus lumborum block could provide comparable analgesic effects for a laparoscopic sleeve gastrectomy in obese patients.Trial registrationChinese Clinical Trial Registry; ChiCTR1800019236.

| S-EPMC9098772 | biostudies-literature

Comparison of ultrasound-guided erector spinae plane block and transversus abdominis plane block in postoperative analgesia of laparoscopic colorectal cancer surgery

Project description:Interventions: TAP:Transversus abdominis plane block;ESP:Erector spinae plane block Primary outcome(s): Visual Analogue Scale Study Design: Randomized parallel controlled trial

| 2680369 | ecrin-mdr-crc

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