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Effect of exercise on fitness in colorectal cancer survivors

ABSTRACT: Background and study aims Cancer has become a major public health problem in South Korea. Lifestyle factors determine the risk of colorectal cancer and the course of the disease. Studies have shown a strong link between the level of physical activity and the outcomes of colorectal cancer. Although observational studies have shown the link between physical activity and the physical fitness of colorectal cancer patients, there are few interventional studies which have shown these beneficial effects Therefore, the aims of this study are to investigate the effects of a 6-week home-based exercise intervention on cardiovascular and musculoskeletal fitness and patients perceived bowel function in stage II-III colorectal cancer survivors. Who can participate? Patients with stage II-III colorectal cancer who have completed all standard cancer-directed therapy at least 4 weeks but no more than 2 years before the study. What does the study involve? Patients are randomly allocated to either the exercise group or the control group. Exercise group patients will be encouraged to walk more than 10,000 steps per day. A pedometer will be provided to count the steps. Patients will be provided with exercise DVDs, which consist of 30 minutes exercise using their own body weight, to be performed at home daily. Following each exercise session, participants will complete their exercise log, recording the daily steps, type of exercise and duration. Exercise group participants will visit the clinic three times during the 6 weeks. They will have two exercise education sessions, and the exercise trainer will make sure that patients are able to perform the exercise properly. Control group patients will be instructed to continue with their usual daily activities. The intervention period will be 6 weeks and assessments will be carried out before the start of the study and at 6 weeks.

DISEASE(S): Stage Ii To Iii Colorectal Cancer Survivors

PROVIDER: 2416369 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC assigned sequentially to exercise (n = 15) and non-exercise (n = 10) groups. Individuals with no PCC served as a control group. The exercise program included cardiovascular and resistance exercises. Physical capacity, physical activity level and the presence of common PCC symptoms were measured before and after the intervention. Fatigue was measured the day following each exercise session. Plasma and PBMC samples were collected at the beginning and end of the training program. Glutathione and deoxyguanosine levels in PBMC and plasma proteomic profiles were evaluated. Results: Bicep Curl (p=0.040) and STS-30 (p=0.043) improved to a greater extent in the exercise group than in the non-exercise group. An interaction effect was also observed for the level of physical activity (p=0.007) with a positive effect of the program on their daily functioning and without any adverse effects on general or post-effort fatigue. Glutathione levels showed marked improvement after exercise. Discernable changes were observed in the plasma proteomics profile with certain proteins involved in inflammatory response (SA100A8) decreasing in the exercise group. Conclusion: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.

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Effect of exercise on fitness in colorectal cancer survivors

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