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Attitudes towards eCommunicationin treatment of chronically ill patients

ABSTRACT: Interventions: Group 1: The EC@T-project consists of three substudies: two qualitative and one quantitative study. In all three studies there will be two sample groups, providers and chronically ill patients (see fulfilling one of the diagnoses). First, within the qualitative study we will interview the attitudes of patients and providers and we are planning to generate items for the EC@T questionnaire. Then all participants will fill out the questionnaire. Primary outcome of the project is to develop the EC@T questionnaire based on interview data and analysis of literature. aim: measurement of attitudes towards eCommunication of providers and chronically ill patients. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: other

DISEASE(S): Crohn Disease Of Large Intestine,Chronic Back Painchronic Ischemic Heart Diseasediabetes Mellitus, Type 1inflammatory Bowel Diseasesdepressive Disordersanxiety Disordersalcoholismbreast Cancer,Mild Depressive Episode,Crohn Disease Of Small Intestine,Inflammatory Polyps,Crohn Disease, Unspecified,Other Anxiety Disorders,Other Crohn Disease,Other Ulcerative Colitis,Left Sided Colitis,Malignant Neoplasm Of Breast,Ulcerative (chronic) Proctitis,Ulcerative (chronic) Rectosigmoiditis,Moderate Depressive Episode,Dorsalgia,Ulcerative (chronic) Pancolitis,Ulcerative Colitis, Unspecified,Type 1 Diabetes Mellitus,Chronic Ischaemic Heart Disease,Phobic Anxiety Disorders,Severe Depressive Episode Without Psychotic Symptoms

PROVIDER: 2430027 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates genetic/biological analyses of these disorders. DNA microarray analyses were conducted on 116 lymphoblastoid cell lines (LCL) from individuals with idiopathic autism who are divided into 3 phenotypic subgroups according to severity scores from the commonly used Autism Diagnostic Interview-Revised questionnaire and age-matched, nonautistic controls. Statistical analyses of gene expression data from control LCL against that of LCL from ASD probands identify genes for which expression levels are either quantitatively or qualitatively associated with phenotypic severity. Comparison of the significant differentially expressed genes from each subgroup relative to the control group reveals differentially expressed genes unique to each subgroup as well as genes in common across subgroups. Among the findings unique to the most severely affected ASD group are genes that regulate circadian rhythm, which has been shown to have multiple effects on neurological as well as metabolic functions commonly dysregulated in autism. Among the genes common to all 3 subgroups of ASD are 5 novel genes which appear to associate with androgen sensitivity, which may underlie the strong 4:1 bias towards affected males. Gene expression profiling of 116 LCL from autistic (87) and nonautistic (29) individuals were obtained using a custom-printed DNA microarray containing 39,936 elements (TIGR 40K Human array, GPL3427) and a reference design in which each sample was compared to the Stratagene Universal Human RNA standard. The 87 autistic samples were divided into phenotypic subgroups (language, mild, savant) on the basis of cluster analyses of scores from an autism diagnostic questionnaire, the Autism Diagnostic Interview-Revised instrument. Differentially expressed genes were determined for all autistic vs. control groups, as well as for each of 3 phenotypic ASD groups and controls.

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Attitudes towards eCommunicationin treatment of chronically ill patients

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