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Risk adapted prevention strategies for colorectal cancer

ABSTRACT: Interventions: Group 1: Persons without family history of colorectal cancer: to fill out online-questionnaire Group 2: Persons with family history of colorectal cancer: to fill out online-questionnaire, take part in consultation regarding colorectal cancer prevention and donate the biosamples Primary outcome(s): The aims of the RaPS study are: 1. To provide the necessary empirical evidence for the design and implementation of efficient risk adapted CRC (colorectal cancer) screening strategies among the high risk group of people with family history of CRC. 2. To identify and evaluate novel biomarkers for noninvasive risk stratification and early detection of CRC and its precursors among people with family history of CRC. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: prevention

DISEASE(S): Malignant Neoplasm Of Colon

PROVIDER: 2431112 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Interventions: Individuals from intervention General Practices who opt in to the study will be given a password, allowing them to access the ‘Family History Website’ tool. This online tool will collect information about their family history of colorectal cancer and encourage discussion with their relatives so that they can gather accurate information. Upon completion of the questionnaire, individuals will be assigned to a NHMRC designated risk category for developing CRC, which will be accompanied by the appropriate screening recommendations, with a personalised summary of their information. This information will be accessible to their GP via a shared access facility, and participants will be encouraged to discuss their results with their GP within the following consultation. The completion of the family history website and GP consultation thereafter, is known as Assessment 1 at time = 0. Participants will be followed up 12 months after their completion of the ‘Family History Website’, where they will be required to self report their five year screening behaviour; while their GP’s will complete a file audit and a survey about the utility of the ‘Family History Website’ tool in addition to their knowledge about CRC risk and screening guidelines. This will be known as assessment 2 at time =1 Primary outcome(s): Outcome Aim: Risk appropriate screening uptake as measured by the participants’ five year screening behaviour in relation to their colorectal cancer risk category Five year screening behaviour- All participants will have their five year screening behaviour recorded at time=1 by self report[12 to 18 months after randomisation, t=1];Colorectal cancer risk category- Intervention practice participants will receive a CRC risk category after completing the ‘Family History Website’ tool., at some time within the 12 month time period t=0. However, participants from control practices will asked about their ‘known family history’ at time=1, and will not be allowed access to the ‘Family History Website’ tool, until after that information is collected.[Within 12 months of the intervention , t=0 for the intervention group and one year after randomisation, t=1 for the control group] Study Design: Purpose: Prevention; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Efficacy

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Risk adapted prevention strategies for colorectal cancer

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