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Evaluation of novel markers for early detection of colorectal cancer

ABSTRACT: Interventions: Group 1: Observational Study with diagnostic intervention: the participants will be asked to donate a blood sample, 2 native stool samples and to perform 2 FIT and one Hemoccult test. Primary outcome(s): sensitivity and specificity of tests for the detection of advanced colorectal neoplasia Study Design: Allocation: N/A: single arm study; Masking: Open (masking not used); Control: uncontrolled; Assignment: single; Study design purpose: diagnostic

DISEASE(S): Malignant Neoplasm Of Rectum,Malignant Neoplasm Of Rectosigmoid Junction,Malignant Neoplasm Of Colon

PROVIDER: 2431308 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Evaluation of novel serological markers for early diagnosis of colorectal neoplasia

Project description:Interventions: Group 1: Observational study: Participants in the colorectal cancer screening program, who undergo colonoscopy and a serological examination. Primary outcome(s): sensitivity and specificity of the three serological tests at predefined cutpoints with colonoscopy as gold standard for ascertainment of colorectal neoplasia Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: diagnostic

| 2429165 | ecrin-mdr-crc

Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret

Project description:Gonadectomy (GDX) induces sex steroid-producing adrenocortical tumors in certain mouse strains and in the domestic ferret. Complementary approaches, including DNA methylation mapping and microarray expression profiling, were used to identify novel genetic and epigenetic markers of GDX-induced adrenocortical neoplasia in female DBA/2J mice. Markers were validated by quantitative RT-PCR, laser capture microdissection, in situ hybridization, and immunohistochemistry. Two genes with hypomethylated promoters, Igfbp6 and Foxs1, were upregulated in post-GDX adrenocortical neoplasms. The neoplastic cells also exhibited hypomethylation of the fetal adrenal enhancer of Sf1, an epigenetic signature that typifies descendants of fetal adrenal rather than gonadal cells. Expression profiling demonstrated upregulation of gonadal-like genes, including Spinlw1, Insl3, and Foxl2, in GDX-induced adrenocortical tumors of the mouse. One of these markers, FOXL2, was detected in adrenocortical tumor specimens from gonadectomized ferrets. These new markers may prove useful for studies of steroidogenic cell development and for diagnostic testing. Total RNA extracted from whole adrenal glands of gonadectomized and non-gonadectomized mice.

2014-07-31 | E-GEOD-54393 | biostudies-arrayexpress

tupiniquim_masked_Axiom_InCor_BB

Project description:Sample genotyped with Axiom InCor BB (Affymetrix) with local ancestry masking of non-Native American ancestry

| EGAD00010001801 | EGA

Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret

2014-07-31 | GSE54393 | GEO

Non-invasive markers for colorectal cancer screening.

Project description:Interventions: Collection of blood and fecal samples (once). Non-invasive markers for colorectal neoplasia will be determined in blood, feces and tissue. All combinations of markers will be tested in order to optimize the diagnostic accuracy for colorectal neoplasia, considering the outcome of colonoscopy as the gold standard. In addition the results of the non-invasive markers in patients at high-risk will be compared with the results of an average-risk population, in order to identify risk factors. Primary outcome(s): Diagnostic accuracy of molecular and protein markers in screening for colorectal neoplasia in subjects at high-risk for CRC and CRC patients, in comparison with average-risk subjects. Study Design: Non-randomized controlled trial, Open (masking not used), N/A , unknown, Parallel

| 15742 | ecrin-mdr-crc

Subtracted Diversity Array identifies novel molecular markers including retrotransposons for fingerprinting Echinacea species

2013-12-31 | GSE44683 | GEO

TRANSIT study

Project description:Interventions: Colonoscopy for obstructive colorectal cancer after insertion of seif-expandable metal stent Primary outcome(s): Detection rate of synchronous colorectal cancer in the proximal side Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, diagnostic purpose

| 2723039 | ecrin-mdr-crc

Identification of novel markers for malignant pleural mesothelioma diagnosis

Project description:Diagnosis of malignant pleural mesothelioma (MPM) is difficult, the most common differential diagnosis being benign pleural diseases and metastatic adenocarcinomas. In order to identify novel markers able to improve diagnostic accuracy, we performed a genome-wide gene expression analysis on tumor cells lines established from pleural effusions (13 MPM and 4 lung adenocarcinoma). Our microarray analysis led to the identification of genes encoding novel cellular and soluble markers whose expression was validated by RT-qPCR. Immunohistochemical staining of tumor biopsies with anti-type-III collagen antibodies were positive in mesothelioma cells but not in adenocarcinoma cells. Using ELISA, we showed that the C-C motif chemokine 2 (CCL2) concentration was significantly higher in pleural effusions from patients with mesothelioma (n = 61) than in subjects with adenocarcinoma (n = 25) or with benign pleural effusions (n = 15): median (interquartile range) = 2.99 ng/mL (1.76-6.01) versus 0.99 ng/mL (0.51-1.83) and 1.47 ng/mL (0.80-1.56), respectively, P < 0.0001. Conversely, the galectin-3 concentration was lower in mesothelioma: 11.50 ng/mL (6.73-23.53) versus 24.74 ng/mL (20.42-70.35) and 17.64 ng/mL (14.81-24.68), respectively, P < 0.0001. The AUC for CCL2 were 0.8030 and 0.7716 for differentiating mesothelioma from adenocarcinoma or benign effusions, respectively. Similarly, the AUC obtained for galectin-3 were 0.7980 and 0.6923, respectively. In conclusion, type-III collagen, CCL2 and galectin-3 are promising new diagnostic markers for mesothelioma.

2009-07-25 | GSE17310 | GEO

A Novel Oral Synbiotic Formula in Reducing Adenoma Recurrence and Colorectal Neoplasia-related Bacterial Gene Markers

Project description:This double blinded randomized controlled trial aims to assess the efficacy of a novel oral synbiotic formula (SMT04) in reducing adenoma recurrence and colorectal neoplasia-related bacterial gene markers after endoscopic resection of colorectal advanced neoplasia.

| 2752397 | ecrin-mdr-crc

Subtracted Diversity Array identifies novel molecular markers including retrotransposons for fingerprinting Echinacea species

Project description:Echinacea, native to the Canadian prairies and the prairie states of the United States, has a long tradition as a folk medicine for the Native Americans. Currently, Echinacea are among the top 10 selling herbal medicines in the U.S. and Europe, due to increasing popularity for the treatment of common cold and ability to stimulate the immune system. However, the genetic relationships within the species of this genus are unclear, which makes difficult the authentication of the species used for the medicinal industry. We report the construction of a novel Subtracted Diversity Array (SDA) for Echinacea species and demonstrate the potential of this array for isolating highly polymorphic sequences. In order to selectively isolate Echinacea-specific sequences, a Suppression Subtractive Hybridization (SSH) was performed between a pool of twenty-four Echinacea genotypes and a pool of other angiosperms and non-angiosperms. A total of 283 subtracted genomic DNA (gDNA) fragments were amplified and arrayed. Twenty-seven Echinacea genotypes, including four that were not used in the array construction, could be successfully discriminated. Interestingly, unknown samples of E. paradoxa and E. purpurea could be unambiguously identified from the cluster analysis. Furthermore, this Echinacea-specific SDA was also able to isolate highly polymorphic sequences. Five out of the eleven most discriminatory features matched to known retrotransposons.

2013-12-31 | E-GEOD-44683 | biostudies-arrayexpress

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