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Prospective, randomized analysis of the development of operative skills for 3D- and 2D assisted minimally invasive surgery

ABSTRACT: Interventions: Group 1: 3D-assisted minmally invasive surgery Group 2: 2D-assisted minmally invasive surgery Primary outcome(s): duration of specific step during surgery Study Design: Allocation: Randomized controlled study; Masking: Blinded (masking used); Control: active; Assignment: parallel; Study design purpose: other

DISEASE(S): Malignant Neoplasm Of Rectum,Diverticular Disease Of Intestine,Diaphragmatic Hernia,Cholelithiasis,Malignant Neoplasm Of Colon,Benign Neoplasm Of Colon, Rectum, Anus And Anal Canal,Inguinal Hernia,Neoplasm Of Uncertain Or Unknown Behaviour Of Endocrine Glands,Other Appendicitis,Acute Appendicitis,Malignant Neoplasm Of Adrenal Gland,Cholecystitis

PROVIDER: 2432031 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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2D and 3D Madin-Darby Canine Kidney Cell Type II cell line response to hepatocyte growth factor

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2014-03-31 | E-GEOD-49518 | biostudies-arrayexpress

Comparison of adhesion complex-associated proteins in MDA-MB-231 cells in a 2D vs 3D microenvironment

Project description:Cell invasion and metastasis is a multi-step process, initiated by the acquisition of a migratory phenotype and the ability to move through differing and complex 3D extracellular environments. In this study we set out to identify the parameters required for invasive cell migration in 3D environments. Cells interact with the extracellular matrix via transmembrane-spanning integrin adhesion complexes. We establish a technique to determine the composition of cell-matrix adhesion complexes in invasive breast cancer cells in 3D matrices and on 2D surfaces and identify an interaction complex that is enriched in 3D adhesion sites and required for invasive migration.

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