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Effect of low-dose acetylsalicylic acid on early detection of advanced colorectal neoplasms


ABSTRACT: Interventions: Group 1: Acetylsalicylic acid (ATC-Code B01AC06), 100mg/day, peroral application, for 4 days. Stool sampling one day before the start of drug intake (baseline, reference sample) and on the 3rd, 4th, and 5th day after start of drug intake (samples after the intervention after different cumulative doses). Primary outcome(s): Effect of three days of repeat intake of 100 mg acetylsalicylic acid (cumulative dose of 3 x 100 mg) on sensitivity for early detection of advanced colorectal neoplasm (defined as colorectal cancer, advanced adenoma or sessile serrated polyp/adenoma in size = 1 cm), measured via a fecal immunochemical test (OC-Sensor) at the predefined cutoff level of 10.0 µg hemoglobin/g feces. Study Design: Allocation: N/A: single arm study; Masking: Open (masking not used); Control: uncontrolled; Assignment: single; Study design purpose: screening

DISEASE(S): Malignant Neoplasm Of Rectum,Screening For Advanced Colorectal Neoplasms.male Individuals Aged 40 To 79 Years Scheduled For Screening Colonscopy And No Use Of Acetylsalicylic Acid (or Other Drugs With An Effect On The Blood ...,Screening Auf Fortgeschrittene Kolorektale Neoplasien. männliche Personen Im Alter Von 50 Bis 79 Jahren, Bei Denen Eine Screening-koloskopie Geplant Ist Und Die Keine Acetylsalicylsäure (oder Anderen Medikamenten Mit Auswirkungen Auf Das Blutgerinnungssystem) Einnehmen.,Malignant Neoplasm Of Rectosigmoid Junction,Advanced Colorectal Neoplasia,Screening For Advanced Colorectal Neoplasms. male Individuals Aged 50 To 79 Years Scheduled For Screening Colonscopy And No Use Of Acetylsalicylic Acid (or Other Drugs With An Effect On The Blood Coagulation System).,Malignant Neoplasm Of Colon

PROVIDER: 2436674 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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