Effect of exercise on bowel realted symptoms on colorectal cancer survivors
Ontology highlight
ABSTRACT:
DISEASE(S): Neoplasms
PROVIDER: 2512729 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
Similar Datasets
Project description:Profiling of circulating miRNAs before, 60 mins, 1day and 3 days after an acute resistance exercise. Three subjects performed an acute resistance exercise. The resistance exercise consisted of two consecutive exercises (bench press and bilateral leg press), consisting of five sets of 10 repetitions at 70% of 1 RM. The subjects were allowed to rest for 1 min between each set and exercise. The subjects were instructed to lift and lower the load at a constant velocity, taking about 2 s for each repetition. If the load became too heavy, the subject was assisted. The range of motion in each exercise was from 90° to 0° (0° at full extension). Blood samples were taken before, 60 mins, 1day and 3days after the exercise.
2013-06-29 | E-GEOD-48405 | biostudies-arrayexpress
Project description:10 male subjects performed ~45 min one-legged cycling and 4 x 7 maximal concentric-eccentric knee extensions for each leg 15 min later. Thus, one limb performed aerobic and resistance exercise (AE+RE), while the opposing leg did resistance exercise only (RE). Biopsies were obtained from m. vastus lateralis of each leg 3 h after the resistance exercise bout. Gene expression analysis was carried out on the Affymetrix HuGene-2.1-st platform.
2016-05-24 | GSE74194 | GEO
Project description:Interventions: Preoperative tailored regimen of exercise with dietary advice.
Exercise will involve up to 12 sessions (maximum of three, 1-hour, small group sessions per week for 4 weeks supervised by an accredited exercise physiologist) of combined strength/cardiovascular/balance exercise in the 4 weeks prior to surgery.
Each exercise session will consist of:
- 5 mins warm-up (treadmill/mobility)
- 30 mins of circuit based combined strength/cardiovascular & balance exercises as follows = 2 sets of 8-12 reps per exercise (50% of predicted 1RM) of chest press, seated row, bicep curl, triceps extension, squat, & leg curl; AND 3-4 sets (1 min per round) of single leg balance (eyes open/closed)
- 20 mins of aerobic interval exercise (walking) based of high and low intensity at a ratio of 1:1 (1 min of higher intensity exercise [e.g. 50% heart rate reserve] interspersed with 1 min of lower intensity [e.g. 25% heart rate reserve]
- 5 mins cool down (treadmill/mobility)
Generic dietary advice will involve a single 1-hour, one-on-one educational session with a allied health professional.
All participants will maintain a diary of all exercise activities during the study.
Primary outcome(s): Aerobic capacity or exercise tolerance, assessed by 6 minute walk distance (6MWD)[Baseline, pre-operation and ~30 days follow-up.]
Study Design: Purpose: Treatment; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Efficacy
| 2463072 | ecrin-mdr-crc
Project description:Intervention group:Nutritional intervention: NRS2002 assessment scale = 3 points; it is recommended that patients consume 1.2g/kg protein per day; on the basis of general diet, the corresponding ONS will be given according to the patient’s basic disease and intestinal function;Intervention group:Sports intervention: 1) Grip exercise: Provide a 10kg grip dynamometer, and ask patients to exercise 20 times a day for the left and right hands.;Intervention group:Exercise intervention: 2) Aerobic exercise: walking: provide patients with step counting devices, and recommend patients to walk at least 7,500 steps (about 1 hour) a day.;Intervention group:Exercise intervention: 3) Resistance exercise: Climbing stairs exercise: It is recommended that patients climb stairs 3 times a day, up and down 5 floors each time.;Intervention group:Sports intervention: 4) Spinning exercise: It is recommended that patients ride the bicycle 3 times a day for 30 minutes each time.;Intervention group:Sports intervention: 5) Respiratory function exercise: Provide patients with balloons and require patients to perform balloon blowing exercises at least 30 times a day.;Intervention group:Mental sleep intervention: daily before going to bed: ? 2 minutes of breathing exercises, 10 minutes of progressive muscle relaxation exercises and 15 minutes of pleasant guided imagination training.;Intervention group:Psychological sleep intervention: daily before going to bed: ?Combined with the patient’s usual preferences, choose light music, 15-30 minutes before going to bed every day.;Intervention group:Psychological sleep intervention: daily before going to bed: ?Use sedative and sleeping drugs for patients with difficulty falling asleep and sleep disorders.;Control group:Nutritional evaluation before surgery: assess the nutritional status of the patient, instruct the patient to eat a high-protein, high-calorie, high-vitamin diet; eat a small amount of meals, and give supplementary parenteral nutrition su
Primary outcome(s): Complications within 30 days after surgery
Study Design: Parallel
| 2701118 | ecrin-mdr-crc
Project description:Maternal blood, as well as umbilical cord blood samples, were collected and DNA methylation levels were determined by Illumina MethylationEPIC microarray. Methods: Twenty-four subjects were chosen from a previous clinical study. Overweight/obese pregnant women (body mass index ≥24kg/m2) who had an uncomplicated pregnancy at <12+6 weeks of gestation were randomly allocated to either an exercise or a control group. Patients allocated to the exercise group performed 3 exercise bouts per week (at least 30 min/session with a rating of perceived exertion between 12-14) via a cycling program that was initiated within 3 days of randomization until 37 weeks of gestation. Patients allocated to the control group continued their usual daily activities. Maternal blood, as well as umbilical cord blood samples, were collected and DNA methylation levels were determined by Illumina MethylationEPIC microarray.
2024-04-16 | GSE172208 | GEO
Project description:Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC assigned sequentially to exercise (n = 15) and non-exercise (n = 10) groups. Individuals with no PCC served as a control group. The exercise program included cardiovascular and resistance exercises. Physical capacity, physical activity level and the presence of common PCC symptoms were measured before and after the intervention. Fatigue was measured the day following each exercise session. Plasma and PBMC samples were collected at the beginning and end of the training program. Glutathione and deoxyguanosine levels in PBMC and plasma proteomic profiles were evaluated. Results: Bicep Curl (p=0.040) and STS-30 (p=0.043) improved to a greater extent in the exercise group than in the non-exercise group. An interaction effect was also observed for the level of physical activity (p=0.007) with a positive effect of the program on their daily functioning and without any adverse effects on general or post-effort fatigue. Glutathione levels showed marked improvement after exercise. Discernable changes were observed in the plasma proteomics profile with certain proteins involved in inflammatory response (SA100A8) decreasing in the exercise group. Conclusion: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.
2024-10-17 | PXD047623 | Pride
Project description:Interventions: This study was a 16-week exercise intervention programme done prior to surgery with assessments undertaken at three time-points: (1) baseline, (2) immediately pre-surgery and (3) 8-week post-surgery follow-up. This is a 16 weeks exercise programme that commenced prior to the schedule surgery. Patients undertook an exercise programme that consisted of two supervised clinic sessions per week. Each supervised exercise session took approximately 60 minutes to complete. Sessions commenced with a 5-minute warm-up consisting of moderate level of aerobic exercise (~60% heart rate maximum (HRmax)), as well as stretching exercises of the major muscle groups: chest, shoulder, biceps, triceps, quadriceps, hamstrings and calf muscles. This was followed by a resistance-training regime that included a series of six exercises targeting the major muscles of the upper- and lower-body. Upper-limb exercises included chest press, seated row and lat pull-down. Lower-limb exercises were leg extension, leg curl and leg press. All exercises were performed through the full range of motion adhering to correct techniques. To ensure the progressive nature of the training programme, patients were encouraged to work past the repetition maximum (RM) prescribed, with resistance increased by 5 – 10% for the subsequent set/training sessions if they were able to exceed the number specified. Progression of resistance followed guidelines previously outlined by Galvao and Newton (2005). The training phases were as follows: week 1 – 2 (two sets 12 RM), week 3 – 5 (three sets of 10 RM), week 6 – 8 (three sets of 8 RM), and week 9 – 10 (four sets of 6 RM). After week 10, the training phases set in week 1 – 2 were resumed to implement a periodised exercise model. A further 20 minutes of aerobic exercise was unde
Primary outcome(s): The primary objective of this feasibility study was to determine the efficacy of a supervised, pre-surgical exercise programme consisting of targeted resistance and aerobic training for rectal cancer patients scheduled to received rectal resection surgery. Specifically, we aimed to investigate the effects of a pre-surgical exercise intervention on neuromuscular strength using the one-repetition maximum chest press, leg press, seated row and leg extension exercise protocol[Baseline, pre-surgery and 8-weeks post-surgery]
Study Design: Purpose: Prevention; Allocation: Non-randomised trial
| 2463629 | ecrin-mdr-crc
Project description:To characterize phosphorylation-based signaling events across different exercise modalities we subjected eight healthy young men (age, 26.3±1.3 years; BMI, 23.5±0.7 kg/m2; maximal oxygen uptake (VO2 max), 42.6±1.5 ml/kg/min) that did not perform regular physical activity apart from local bicycling to an acute bout of endurance (90 min ~60% of VO2 max), sprint (3 x 30-s all-out cycling), or resistance exercise (6 sets of 10 RM knee extensions) in the fasting state. All participants completed the three types of exercise in a randomized crossover design with 14 days washout between each exercise bout.
2022-07-18 | PXD031049 | Pride
Project description:The study has been described in the following paper: Gianni Parise, Stuart M. Phillips, Jan J. Kaczor and Mark A. Tarnopolsky (2005). Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radical Biology and Medicine, Volume 39, Issue 2, 15 July 2005, Pages 289-295 We cite the following three paragraphs from this paper: "MATERIALS AND METHODS Subjects Twelve men (71.2 ± 6.5 y) volunteered to participate in a 12 week uni-lateral leg resistance training program (Table 1). All subjects underwent a thorough screening process before being admitted into the study. Subjects were first screened by telephone, and were then subject to a medical evaluation. Consent from their family physician was required, and then all potential subjects underwent a resting electrocardiogram, and a sub-maximal graded exercise test on a bicycle ergometer witih a 12-lead ECG. Exclusion criteria included: evidence of coronary hear disease; congestive heart failure; uncontrolled hypertension; chronic obstructive pulmonary disease; diabetes mellitus; renal failure; major orthopaedic disability; and smoking. None of the subjects had ever participated in a structured exercise program. After subjects were advised of the benefits and risks of participation, subjects gave their written informed consent. The study was approved by the McMaster University and Hamilton Health Sciences Research Ethics Board and conferred to the principles of the declaration of Helsinki. Exercise Training Resistance training was performed three times weekly on non-consecutive days (Monday, Wednesday, and Friday) for 12 weeks, under strict supervision. Prior to and after each training session subjects were required to perform passive stretching. Resistance exercise for each session consisted of 3 sets of 10 repetitions for each of leg press and leg extension. Training progressed from one set of each exercise at 50% of the initial 1 repetition maximum (1RM) to 3 sets at 80% of 1RM over the training period. Training logs were kept to record the volume and intensity of each session. The 1RM was re-evaluated every 2 weeks, and the training load was adjusted accordingly. All exercises were performed on universal strength training equipment (Universal Gym Equipment, Inc., Cedar Rapids, Iowa). Muscle Biopsy A muscle biopsy was taken from the vastus lateralis muscle of both legs before as well as after the training period, 20 cm proximal to the knee joint using a modified Bergström needle (5 mm diameter) with suction modification. The biopsy specimen was dissected of fat and connective tissue and immediately frozen in liquid nitrogen. All samples were stored at -80 °C for subsequent analysis. All subjects were required to abstain from strenuous physical activity for 48 hours prior to the testing session. The non-trained leg performed an acute bout of exercise at the same relative intensity of the training leg to allow for the determination of the effect of training and the effect of acute resistance exercise." Additional Notes: 1) The samples of 8 out 12 were used in the gene expression study. 2) The 2 factors in this study are: 2.1) Leg - Left or Right 2.2) Training - Baseline: samples taken on each leg before exercise - Resistance Training: one of the legs was subject to resistance training followed by acute exercise - Acute Exercise: the other leg had only the acute exercise 3) The baseline samples will be used for right versus left leg comparison to see variance between legs for human experimentation technical issues. The samples from Resistance or Acute Exercise will be compared to corresponding baseline samples to evaluate the effect of both exercise programs on gene expression.
2007-06-07 | E-MEXP-740 | biostudies-arrayexpress
Project description:Intervention1: STRUCTURED EXERCISE PROGRAM: Structured exercises:
POD 1-2In sitting position
Warm up exercises:- (5 min)
-stretching of:
â?¢Neck
â?¢Wrist
â?¢Ankle
-Chest physiotherapy: (5-7 sec)
-Breathing exercises: Diaghpramatic exercise
Segmental exercise
-Thoracic expansion exercises.
-Bed mobility exercise: (5-7 sec)
â?¢Active ROM of
-Neck- Flexion and extension
Lateral flexion and rotation
-Shoulder- flexion and extension
Abduction and adduction,
-Elbow- Flexion and extension
-Wrist- flexion and extension,
Ulnar and Radial movement
-Hip: flexion, abduction, adduction
(In supine lying position)
-Knee: Flexion and extension
-Ankle: Dorsi and Plantar Flexion
Ankle toe movement
-Static abdominal (3-5 sec hold)
Supervised walking
Cool down exercise
POD 3-5Same as day 1 exercise +
Resisted exercise for upper and lower limb
(8-10 reps)Supervised walking
Cool down exercise
POD 5-Same as day 3 exercise + single leg standing+ balance training
Supervised walking
Cool down exercise
Control Intervention1: N/A: N/A
Primary outcome(s): â?¢6 MINUTE WALK DISTANCE
â?¢Hand held Dynamometer
â?¢FACT-G
â?¢HADSTimepoint: â?¢6 MINUTE WALK DISTANCE- At baseline and post intervention
â?¢Hand held Dynamometer- At baseline and post intervention
â?¢FACT-G- At baseline and post intervention
â?¢HADS- At baseline and post intervention
| 2603510 | ecrin-mdr-crc