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Open-label, single-arm, multicenter phase II study of matuzumab in combination with irinotecan background chemotherapy in subjects with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer that developed progressive disease while on therapy or within 4 weeks after termination of an irinotecan based regimen.

ABSTRACT: Primary objectives: To determine the response rate of matuzumab in combination with irinotecan background chemotherapy for EGFR-expressing metastatic colorectal cancer which developed PD while on therapy or within 4 weeks after termination of therapy with an irinotecan-based regimen. Primary endpoints: Determination of the response rate by the same imaging technique (CT/MRI) that is used consistently within each subject. Evaluation by investigator and classification by modified WHO criteria.

DISEASE(S): Epidermal Growth Factor Receptor (egfr) Expressing, Metastatic Colorectal Cancer

PROVIDER: 2517330 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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