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Sirolimus and Hepatitis C following Liver Transplantation


ABSTRACT: Primary objectives: We believe that patients who have had a liver transplant and are infected with Hepatitis C will develop less scarring (fibrosis) in their transplant liver if their anti-rejection (immunosuppressant)medication is switched from a calcineurin inhibitor (current standard therapy) to Sirolimus. This trial will test this hypothesis. Primary endpoints: The primary endpoint is change in fibrosis stage over the study period.

DISEASE(S): Pleural Effusion,Arthralgia,Purpura Thrombocytopenic,Osteonecrosis,Exfoliative Dermatitis,Post Transplant Lymphoproliferative Disorder,Disturbance Of Liver Function Tests,Impaired Healing,Pyrexia,Epstein-barr Viral Infections,Oedema Peripheral,Leukopenia,Herpes Zoster,Pancreatitis,Hypophosphataemia,Hypersensitivity Vasculitis,Epistaxis,Stomatitis,Pulmonary Haemorrhage,Pneumonitis,Urinary Tract Infections,Herpes Viral Infections,Angioedemas,Diarrhoea,Neutropenias,Transplant Rejections,Patients Who Have Undergone Liver Transplantation And Are Infected With Hepatitis C Virus.,Rash,Hyperglycaemia,Anaemia,Deep Vein Thrombosis,Hypertriglyceridaemia,Oedema,Abdominal Pain,Thrombocytopenias,Nephrotic Syndrome,Skin Cancer,Anaphylaxis,Cytomegalovirus Infection,Blood Lactate Dehydrogenase Increased,Acute Pyelonephritis,Hypercholesterolaemia,Mycobacterial Infectious Disorders,Acne,Respiratory Tract Infections,Septicaemia,Haemolytic Uraemic Syndrome,Lymphocele,Pericardial Effusion,Lymphoedema,Tachycardia,Hypokalaemia,Pancytopenia,Pulmonary Embolism,Fungal Sepsis,Proteinuria

PROVIDER: 2523820 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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