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Phase II study of temozolomide in metastatic colorectal cancer patients resistant to standard therapies and with O6-methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation

ABSTRACT: Primary objectives: To assess the antitumor activity in terms of Progression Free Survival (PFS) at 12 weeks since the start of temozolomide in patients with mCRC after failure of at least 2 lines of prior therapy, including fluoropyrimidine-, irinotecan-, oxaliplatin- and, in case of KRAS wild-type, panitumumab- or cetuximab containing therapy Primary endpoints: PFS rate at 12 weeks, i.e. the proportion of patients known to be alive and progression free at 12 weeks or later since treatment start. The primary efficacy analysis will be performed on the proportion of treated patients in a progression free-status at 12 weeks.

DISEASE(S): Metastatic Colorectal Cancer,Patients With Metastatic Colorectal Cancer Resistant To Standard Therapies And With O6-methylguanine-dna Methyltransferase (mgmt) Promoter Hypermethylation.,Patients With Metastatic Colorectal Cancer Resistant To Standard Therapies And With O6-methylguanine-dna Methyltransferase (mgmt) Promoter Hypermethylation.,Pazienti Affetti Da Tumore Metastatico Del Colon-retto, Resistenti Alle Terapie Standard E Con Ipermetilazione Dell'enzima O6-metilguanina-dna Metiltransferasi (mgmt).

PROVIDER: 2531183 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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