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Randomised study to investigate FOLFOXIRI plus Cetuximab or FOLFOXIRI plus bevacizumab as first-line treatment of BRAF-mutated metastatic colorectal cancer (FIRE 4.5)

ABSTRACT: Primary objectives: To compare the objective response rate (ORR) according to RECIST 1.1 of treatment with FOLFOXIRI plus cetuximab versus treatment with FOLFOXIRI plus bevacizumab in BRAF-mutated patients.

DISEASE(S): Metastatic Colorectal Cancer,Histologisch Gesichertes Adenokarzinom Des Kolons Oder Rektums Im Uicc Stadium Iv Mit Metastasen (metastasiertes Kolorektales Karzinom [mkrk]), Metastasen Primär Nicht Resektabel Oder Patient Lehnt Operation Ab; Ras - Wildtyp-status (kras Und Nras Exone 2,3,4) Des Tumors (nachgewiesen In Primärtumor Oder Metastase); Braf Mutierter (v600e) Tumor (nachgewiesen In Primärtumor Oder Metastase),Histologically Confirmed, Uicc Stage Iv Adenocarcinoma Of The Colon Or Rectum With Metastases (metastatic Colorectal Cancer, Mcrc), Primarily Non-resectable Or Surgery Refused By The Patient; Ras ...,Histologically Confirmed, Uicc Stage Iv Adenocarcinoma Of The Colon Or Rectum With Metastases (metastatic Colorectal Cancer, Mcrc), Primarily Non-resectable Or Surgery Refused By The Patient; Ras Wild-type Tumour Status (kras And Nras Exons 2, 3, 4) (proven In The Primary Tumour Or Metastasis); Braf-mutated (v600e) Tumour (proven In The Primary Tumour Or Metastasis)

PROVIDER: 2535112 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab 1st-line in BRAF-mutated mCRC

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