The effects of the proton pump inhibitor esomeprazole alone or in combination with Coca-Cola on the absorption of Capecitabine in patients with cancer ‘the COCA study’
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ABSTRACT: Primary objectives: 1. To evaluate the area under the plasma concentration-time curve (AUC) of capecitabine alone, compared to capecitabine used with esomeprazole and compared with capacitabine used with esomeprazole and the acid beverage Coca-Cola Classic in patients with CRC or other solid tumours.
Primary endpoints: To evaluate the area under the plasma concentration-time curve (AUC) of capecitabine alone, compared to capecitabine used with esomeprazole and compared with capacitabine used with esomeprazole and the acid beverage Coca-Cola Classic in patients with CRC or other solid tumours.
DISEASE(S): Colorectal Carcinoma Or Other Solid Tumours,Colorectal Carcinoom Of Een Ander Type Solide Tumor
PROVIDER: 2537538 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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