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Clinical trial to compare the efficacy of two treatment sequencing schemes with chemotherapy (the regime called FOLFOX and FOLFIRI) in combination with biologic drugs (panitumumab and bevacizumab).

ABSTRACT: Primary objectives: To compare the progression free survival rate (PFSR) at 35 months of FOLFOX + panitumumab followed by FOLFIRI + bevacizumab (Sequence 1) versus FOLFOX + bevacizumab followed by FOLFIRI + panitumumab (Sequence 2) in patients with wild-type RAS, primary left-sided, mCRC. Primary endpoints: •35-month PFSR defined as the number of patients, who at 35 months after randomization, have nothad second† or first†† disease progression nor died (due to any cause), over the total number of evaluable patients.† In patients who have initiated the second line-treatment after a first progression†† In patients who have not initiated the second line-treatment because a first disease progression has not been observed or patients who for medical reason have initiated the second line-treatment without a first progression

DISEASE(S): Metastatic Colorectal Cancer,Cancer Colorectal Metastasico

PROVIDER: 2537811 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Analysis of 2nd line panitumumab + FOLFIRI efficacy in wild type RAS converted subjects from initially mutated RAS subjects with metastatic colorectal cancer treated in 1st line with standard FOLFOX + bevacizumab treatment.

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