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Measures to improving cognitive and non cognitive functions while receiving chemotherapy for cancer of large intestine

ABSTRACT: Intervention1: Exercise and Vit D supplement: STUDY PARTICIPANTS WILL BE TAUGHT EXERCISE TO BE CARRIED OUT MINIMUM 2.5 HOURS/ WEEK FOR 12 MONTHS FROM THE TIME OF RECRUITMENT AND WILL BE GIVEN VIT D SUPPLEMENTS OF 60,000 I.U. PER WEEK TO BE CONSUMED ORALLY FOR THE 1ST 4 WEEKS FOLLOWED BY 60,000 I.U. EVERY ALTERNATE WEEK FOR 8 WEEKS THE EFFECT WILL BE MEASURED USING STANDARDISED INSTRUMENTS FOR COGNITIVE AND NON COGNITIVE FUNCTIONS Control Intervention1: Standard treatment: It will be prescribed by the treating medical oncologist Primary outcome(s): I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months

DISEASE(S): Malignant Neoplasm Of Colon, Unspecified

PROVIDER: 2591022 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Background: Pre-diabetes condition precedes the Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, preventing DM development. In the present study, we hypothesized that physical exercise training could modify the epigenetic patterns of women with poor glycemic control. Methods: 48 post-menopause women aged 60.3±4.5 years were divided according to the fasting blood glucose levels into two groups: Prediabetes Group, PG (n=24) and Normal Glucose Group, NGG (n=24). All participants performed 14 weeks of physical exercise three times a week. The Infinium Methylation EPIC BeadChip measured the participants’ Different Methylated Regions (DMRs). Results: Before the intervention, the PG group had 12 DMRs compared to NGG. After the intervention, five DMRs remained different. Interestingly, when comparing the PG group before and after training, 118 DMRs were found. The enrichment analysis revealed that the genes were related to different biological functions such as energy metabolism, cell differentiation, and tumor suppression. Conclusion: Physical exercise is a relevant alternative in treating hyperglycemia and preventing DM in post-menopause women with poor glycemic control.

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| 2455008 | ecrin-mdr-crc

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