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Measures to improving cognitive and non cognitive functions while receiving chemotherapy for cancer of large intestine

ABSTRACT: Intervention1: Exercise and Vit D supplement: STUDY PARTICIPANTS WILL BE TAUGHT EXERCISE TO BE CARRIED OUT MINIMUM 2.5 HOURS/ WEEK FOR 12 MONTHS FROM THE TIME OF RECRUITMENT AND WILL BE GIVEN VIT D SUPPLEMENTS OF 60,000 I.U. PER WEEK TO BE CONSUMED ORALLY FOR THE 1ST 4 WEEKS FOLLOWED BY 60,000 I.U. EVERY ALTERNATE WEEK FOR 8 WEEKS THE EFFECT WILL BE MEASURED USING STANDARDISED INSTRUMENTS FOR COGNITIVE AND NON COGNITIVE FUNCTIONS Control Intervention1: Standard treatment: It will be prescribed by the treating medical oncologist Primary outcome(s): I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months

DISEASE(S): Malignant Neoplasm Of Colon, Unspecified

PROVIDER: 2591022 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Myokine irisin is a critical regulator of cognitive function III

Project description:Identifying secreted mediators driving the cognitive benefits of exercise holds great promise for the treatment of cognitive decline in aging or Alzheimer’s disease (AD). Here, we show that irisin, the cleaved and circulating form of the exercise-induced membrane protein FNDC5, is sufficient to confer the exercise benefits on cognitive function. Genetic deletion of FNDC5/irisin (global F5KO mice) impairs cognitive function in exercise, aging, and AD. Diminished pattern separation in F5KOs can be rescued by delivering irisin directly into the dentate gyrus, suggesting that irisin is the active moiety. In F5KOs, adult-born neurons in the dentate gyrus are morphologically, transcriptionally, and functionally abnormal. Importantly, elevation of circulating irisin levels by peripheral administration, resulting in enrichment of central irisin, was sufficient to improve both the cognitive deficit and neuropathology in AD mouse models. Irisin is a crucial regulator of cognitive benefits of exercise and potential therapeutic for treating cognitive disorders including AD.

2021-08-11 | GSE179078 | GEO

Myokine irisin is a critical regulator of cognitive function II

2021-08-11 | GSE174211 | GEO

Myokine irisin is a critical regulator of cognitive function I

2021-08-11 | GSE174210 | GEO

Acute versus long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention

2023-02-01 | GSE224310 | GEO

Fourteen-weeks combined exercise epigenetically modulated 118 genes of menopausal women with prediabetes

Project description:Background: Pre-diabetes condition precedes the Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, preventing DM development. In the present study, we hypothesized that physical exercise training could modify the epigenetic patterns of women with poor glycemic control. Methods: 48 post-menopause women aged 60.3±4.5 years were divided according to the fasting blood glucose levels into two groups: Prediabetes Group, PG (n=24) and Normal Glucose Group, NGG (n=24). All participants performed 14 weeks of physical exercise three times a week. The Infinium Methylation EPIC BeadChip measured the participants’ Different Methylated Regions (DMRs). Results: Before the intervention, the PG group had 12 DMRs compared to NGG. After the intervention, five DMRs remained different. Interestingly, when comparing the PG group before and after training, 118 DMRs were found. The enrichment analysis revealed that the genes were related to different biological functions such as energy metabolism, cell differentiation, and tumor suppression. Conclusion: Physical exercise is a relevant alternative in treating hyperglycemia and preventing DM in post-menopause women with poor glycemic control.

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Evaluation of a brain training programme in cancer survivors self reporting cognitive changes

Project description:Interventions: A home based, computerised cognitive rehabilitation programme to be used for 4x forty-minute sessions per week for a total of 15 weeks (i.e. 40 hours). There are five training exercises that form the core of the program, each targeting a different area of brain functioning. These cognitive targets include visual precision, divided attention, working memory, useful field of view and visual processing speed. Each exercise has an accompanying assessment that sets an improvement goal and measures progress against that goal. The exercises adapt to an individual’s performance and all patients will complete a recommended schedule of training as per the programme design. Primary outcome(s): The primary endpoint is self reported cognitive function as assessed by the Functional Assessment of Cancer Therapy - Cognitive Function (FACT-COG). The primary outcome will be the difference between the intervention group and the control group in the change in FACT-COG score on completion of the cognitive rehabilitation program compared to the baseline score.[Self reported cognitive function as measured by FACT-COG will be evaluated at 3 time points. These assessments will be at baseline, on completion of the 15 week intervention and 6 months following completion of the intervention.] Study Design: Purpose: Treatment; Allocation: Randomised controlled trial; Assignment: Parallel;Type of endpoint: Safety/efficacy

| 2455008 | ecrin-mdr-crc

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