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Use of Modified frailty Index (mFi) for prediction of postoperative complications in patients undergoing Cytoreductive surgery with Hyperthermic Intraperitoneal Chemotherapy

ABSTRACT: Interventions: Control Intervention1: Nil: Nil Control Intervention2: Nil: Nil Primary outcome(s): Major post operative complications (clavien dindo class 3-4) within 30 post operative daysTimepoint: Date of surgery to 30 days post operative period

DISEASE(S): Malignant Neoplasm Of Intestinal Tract, Part Unspecified

PROVIDER: 2604089 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Timed Up & Go Test for Predicting Postoperative Morbidity In Elderly Patients Undergoing Major Abdominal Surgery.

Project description:Intervention1: NIL: NIL Control Intervention1: NIL: NIL Primary outcome(s): Relationship Between TUG And Morbidity During The First 30 Days After Surgery. Morbidity Will Be Registered Using The Clavien-Dindo Classification. Timepoint: First 30 Days After Surgery.

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Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications

Project description:Patients having major surgery experience inflammation post-operatively, which may contribute to post-operative morbidity. Endogenous glucocorticoids (GCs) are an essential part of the stress response, but this response varies between individuals, which may in turn affect clinical outcome in general, and post-operative inflammation, specifically. Exon 1 of the NR3C1 gene, encoding the glucocorticoid receptor, contains an established region of differential regulation. DNA methylation patterns in this region have been found to differ between individuals. We investigated the methylation status and genotype in the Cytosine-phosphate-Guanine (CpG) island in exon 1 of NR3C1 in 24 patients who underwent major abdominal surgery and correlated it with post-operative complications. DNA was extracted from peripheral blood leukocytes and underwent targeted bisulfite sequencing of the CpG island. Complications were graded according to the Clavien-Dindo classification and 14 out of 24 had post-operative complications. Multifactorial and partial least square methods were used to analyse the data. A homogenous demethylated pattern was observed in all patients and no single CpG methylation was associated with post-operative complications. Four single nucleotide polymorphisms (SNPs) were significantly correlated with higher Clavien-Dindo scores. Genetic variability in the chr5:143,402,505-143,405,805 region of exon 1 of the glucocorticoid receptor gene NR3C1, but not DNA methylation, was associated with more severe post-operative complications in patients having major abdominal surgery. This indicates that the response to GCs may be of clinical importance for inflammatory conditions.

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Pre surgery assessment and surgical outcomes after high risk cases of abdominal cancers

Project description:Intervention1: NA: NA Control Intervention1: NA: NA Primary outcome(s): Postoperative complications as per Clavien Dindo class of complicationsTimepoint: From day of surgery to 30 days postoperatively

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Preoperative assessment and postoperative outcomes after high risk cases of abdominal cancers

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Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis

Project description:The purpose of this trial is to compare the morbidity and mortality of CRS-HIPEC using mitomycin-C versus melphalan for colorectal peritoneal carcinomatosis. Morbidity and mortality will measured using the Comprehensive Complication Index (CCI) score, Common terminology criteria for adverse events (CTCAE version 4.03), and the Clavien-Dindo Classification.

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Mucosal gene expression profiling in ileum of patients with Crohn's disease

Project description:In this study, we investigated gene expression profiles in ileal mucosa from CD patients in different settings (post-operative CD (Rutgeerts score i0); post-operative recurrent CD (i1), post-operative recurrent CD (≥i2b), newly diagnosed CD and late stage CD)) and controls.

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Major surgery induces acute changes in DNA methylation associated with immune response pathways

Project description:Using a longitudinal study design, we quantified DNA methylation across the genome in a cohort of 30 elderly patients (average age = 77.9 years (range 62-91)) undergoing major surgery (either elective colorectal surgery, elective hip replacement surgery, and emergency hip surgery following fracture). From each individual, detailed clinical blood measures were collected and DNA methylation was profiled using the Illumina Human Methylation 450 array (g450K arrayh) (Illumina Inc. San Diego, California) in DNA samples isolated from purified PBMCs collected at three time-points: i) immediately before surgery (baseline (BL)), ii) in the morning of post-operative day 1 (POD1) and iii) between post-operative day 4 and 7 (POD4/7) prior to discharge from hospital.

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RNA-sequencing in skeletal muscle from a mouse model of laparotomy with pre-operative running wheel exercise

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Myeloid-derived Suppressor Cells in Colorectal Cancer

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