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Use of Modified frailty Index (mFi) for prediction of postoperative complications in patients undergoing Cytoreductive surgery with Hyperthermic Intraperitoneal Chemotherapy

ABSTRACT: Interventions: Control Intervention1: Nil: Nil Control Intervention2: Nil: Nil Primary outcome(s): Major post operative complications (clavien dindo class 3-4) within 30 post operative daysTimepoint: Date of surgery to 30 days post operative period

DISEASE(S): Malignant Neoplasm Of Intestinal Tract, Part Unspecified

PROVIDER: 2604089 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Timed Up & Go Test for Predicting Postoperative Morbidity In Elderly Patients Undergoing Major Abdominal Surgery.

Project description:Intervention1: NIL: NIL Control Intervention1: NIL: NIL Primary outcome(s): Relationship Between TUG And Morbidity During The First 30 Days After Surgery. Morbidity Will Be Registered Using The Clavien-Dindo Classification. Timepoint: First 30 Days After Surgery.

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Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications

Project description:Patients having major surgery experience inflammation post-operatively, which may contribute to post-operative morbidity. Endogenous glucocorticoids (GCs) are an essential part of the stress response, but this response varies between individuals, which may in turn affect clinical outcome in general, and post-operative inflammation, specifically. Exon 1 of the NR3C1 gene, encoding the glucocorticoid receptor, contains an established region of differential regulation. DNA methylation patterns in this region have been found to differ between individuals. We investigated the methylation status and genotype in the Cytosine-phosphate-Guanine (CpG) island in exon 1 of NR3C1 in 24 patients who underwent major abdominal surgery and correlated it with post-operative complications. DNA was extracted from peripheral blood leukocytes and underwent targeted bisulfite sequencing of the CpG island. Complications were graded according to the Clavien-Dindo classification and 14 out of 24 had post-operative complications. Multifactorial and partial least square methods were used to analyse the data. A homogenous demethylated pattern was observed in all patients and no single CpG methylation was associated with post-operative complications. Four single nucleotide polymorphisms (SNPs) were significantly correlated with higher Clavien-Dindo scores. Genetic variability in the chr5:143,402,505-143,405,805 region of exon 1 of the glucocorticoid receptor gene NR3C1, but not DNA methylation, was associated with more severe post-operative complications in patients having major abdominal surgery. This indicates that the response to GCs may be of clinical importance for inflammatory conditions.

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Pre surgery assessment and surgical outcomes after high risk cases of abdominal cancers

Project description:Intervention1: NA: NA Control Intervention1: NA: NA Primary outcome(s): Postoperative complications as per Clavien Dindo class of complicationsTimepoint: From day of surgery to 30 days postoperatively

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Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis

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Mucosal gene expression profiling in ileum of patients with Crohn's disease

Project description:In this study, we investigated gene expression profiles in ileal mucosa from CD patients in different settings (post-operative CD (Rutgeerts score i0); post-operative recurrent CD (i1), post-operative recurrent CD (≥i2b), newly diagnosed CD and late stage CD)) and controls.

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Major surgery induces acute changes in DNA methylation associated with immune response pathways

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RNA-sequencing in skeletal muscle from a mouse model of laparotomy with pre-operative running wheel exercise

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Myeloid-derived Suppressor Cells in Colorectal Cancer

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NMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Project description:<p>Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operative inflammation, bacterial and viral infection and infection with or without organ dysfunction. 1D 1H nuclear magnetic resonance spectra were acquired in plasma samples from critically ill children. We included children with bacterial (n = 25) and viral infection (n = 30) and controls (n = 58) (elective cardiac surgery without infection). Principal component analysis was used for data exploration and partial least squares discriminant analysis models for the differences between groups. Area under receiver operating characteristic curve (AUC) values were used to evaluate the models. Univariate analysis demonstrated differences between controls and bacterial and viral infection. There was excellent discrimination between bacterial and control (AUC = 0.94), and viral and control (AUC = 0.83), with slightly more modest discrimination between bacterial and viral (AUC = 0.78). There was modest discrimination (AUC = 0.73) between sepsis with organ dysfunction and infection with no organ dysfunction. In critically ill children, NMR metabolomics differentiates well between those with a post-operative inflammation but no infection, and those with infection (bacterial and viral), and between sepsis and infection.</p>

2020-11-19 | MTBLS563 | MetaboLights

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