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Tapered Tip Hood with an Air Bubble Outlet in Underwater Colorectal ESD: A Prospective Study

ABSTRACT: Interventions: Underwater endoscopic submucosal dissection using a tapered tip hood with an air bubble outlet Primary outcome(s): Rate of hood-use completion Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

DISEASE(S): Underwater Endoscopic Submucosal Dissection,Early Colorectal Cancer, Colorectal Neuroendocrine Tumor

PROVIDER: 2614769 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Underwater ESD vs Conventional ESD for SCN

Project description:Interventions: Procedure/Surgery : underwater endoscopic submucosal dissection - after submucosal injection, partial circumferential submucosal incision around the superficial colorectal neoplasia, and then conducted submucosal dissection with water pressure assisted traction on underwater conventional endoscopic submucosal dissection - after submucosal injection, partial circumferential submucosal incision around the superficial colorectal neoplasia, and then conducted submucosal dissection Primary outcome(s): procedure time (measured as the time from the submucosal injection to complete removal of the superficial colorectal neoplasia based on endoscopic assessment) Primary Purpose : Treatment, Intervention Model : Parallel, Blinding/Masking : , Blinding Target : Subject, Allocation : RCT

| 2727762 | ecrin-mdr-crc

A randomized controlled trial on the usefulness of underwater endoscopic submucosal dissection (ESD) versus conventional ESD for colorectal tumors

Project description:Interventions: Underwater ESD group Conventional ESD group Primary outcome(s): Dissection speed Study Design: Parallel Randomized

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CCR3 knockdown attenuates prolonged underwater operation-induced cognitive impairment via alleviating microglia-mediated neuroinflammation

Project description:It is important to maintain cognitive integrity during underwater operations, which may also trigger cognitive alterations. Cognitive effect of underwater operations and the underlying mechanism remain elusive. Here, we found a single underwater operation affects cognition in a time-dependent model. Prolonged exposure elicits significant cognitive impairment and hippocampal dysfunction, which was accompanied by activation of microglia and upregulation of pro-inflammatory cytokines. RNA-sequencing supported the involvement of neuroinflammation and indicated the critical role of CCR3. Knockdown of CCR3 significantly rescued cognitive impairment and hippocampal dysfunction. Furthermore, the upregulation of pro-inflammatory cytokines was also reversed. Mechanistically, CCR3 knockdown switched the activated microglia from a pro-inflammatory to neuroprotective phenotype. Taken together, these results highlighted the time-dependent effects of a single underwater operation on cognitive function. Knocking down CCR3 can attenuate neuroinflammation by regulating polarization of activated microglia, thereby alleviating prolonged underwater operation-induced cognitive impairment.

2024-05-20 | GSE247651 | GEO

Transcriptome gene expression analysis of root tip, leaf tip, shoot tip, root (without root tip) and leaf (without leaf tip) from Ceratopteris richardii sporophytes

Project description:To study genes specially expressed in root tip, leaf tip, shoot tip, root (without root tip) and leaf (without leaf tip) of Ceratopteris richardii, we carried out an RNA-seq to analyze gene expression levels from these five tissues.

2019-10-22 | GSE139160 | GEO

Transcriptome gene expression analysis of root tip, leaf tip, shoot tip, root (without root tip) and leaf (without leaf tip) from Ceratopteris richardii sporophytes

Project description:Transcriptome gene expression analysis of root tip, leaf tip, shoot tip, root (without root tip) and leaf (without leaf tip) from Ceratopteris richardii sporophytes

| PRJNA578676 | ENA

Protistan metabolism across the western North Atlantic Ocean revealed through autonomous underwater profiling

Project description:An Autonomous Underwater Vehicle (AUV) and large volume underwater pumps were used to collect microbial biomass from offshore waters of the Sargasso Sea, from surface waters and into the deep ocean. Seawater collection was performed along a transect in the western North Atlantic Ocean beginning near Bermuda and ending off the coast of Massachusetts, capturing metabolic signatures from oligotrophic, continental margin, and productive coastal ecosystems.

2023-10-25 | PXD045395 | Pride

Microarray Analysis of Retinal Endothelial Tip Cells Identifies CXCR4 as a Mediator of Tip Cell Morphology and Branching

Project description:The development of the vertebrate vascular system is mediated by both genetic patterning of vessels and by angiogenic sprouting in response to hypoxia. Both of these processes depend on the detection of environmental guidance cues by endothelial cells. A specialized subtype of endothelial cell known as the tip cell is believed to be involved in the detection and response to these cues, but the molecular signaling pathways utilized by tip cells to mediate tissue vascularization remain largely uncharacterized. To identify genes critical to tip cell function, we have developed a method to isolate them using laser capture microdissection, permitting comparison of RNA extracted from endothelial tip cells to that of endothelial stalk cells using microarray analysis. Genes enriched in tip cells include ESM-1, Angiopoietin-2, and SLP-76. CXCR4, a receptor for the chemokine SDF-1, was also identified as a tip cell-enriched gene, and we provide evidence for a novel role for this receptor in mediating tip cell morphology and vascular patterning in the neonatal retina.

2010-03-17 | GSE19284 | GEO

air metagenome

Project description:Air Metagenome

| PRJNA360153 | ENA

air metagenome

Project description:Air Metagenome

| PRJNA218551 | ENA

The role of the gene Mest during mouse digit tip regeneration

Project description:The distal mouse digit tip undergoes complex tissue regeneration following amputation, a process facilitated by the formation of a cellular structure called the blastema. Through single-cell RNA sequencing of the blastema, we identified the gene Mest (mesoderm specific transcript) highly expressed in a subset of blastemal fibroblasts. To determine if Mest expression is necessary for mouse digit tip regeneration, we analyzed Mest wildtype (WT) versus homozygous knockout (KO) post amputation digits. Through single-cell sequencing and FACS analysis of WT and KO regenerating tissues, we determined that this phenomenon was due to a prolonged immune response in the KO digits.

2024-07-03 | GSE267553 | GEO

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