Browse
Submit Data
Databases
API
Help

Dataset Information

44 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of Lymphatic flow using indocyanine green fluorescence imaging

ABSTRACT: Interventions: Submucosal injection of indocyanine green Primary outcome(s): Distance from tumor to proximal or distal end of visualized lymphatic flow with indocyanine green fluorescence Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

DISEASE(S): Colorectal Adenocarcinoma

PROVIDER: 2615694 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Evaluation of the intestinal lymph flow and blood flow using Indocyanine green(ICG)fluorescence method in a colorectal surgery

Project description:Interventions: 1 Indocyanine green local injection at the colorectal surgery 2 Indocyanine green intravenous injection at the colorectal surgery Primary outcome(s): 1 Identification rate of lymphatic vessels and fluorescent lymph nodes near the tumor. 2 Evaluation of blood flow of the anastomotic site Study Design: Single arm Non-randomized

| 2641945 | ecrin-mdr-crc

Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs

Project description:In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigated the lymphatic draining function at the tibial fracture sites using near-infrared indocyanine green lymphatic imaging (NIR-ICG) and discovered that lymphatic drainage insufficiency (LDI) started on day one and persisted for up to two weeks following the fracture. Sufficient lymphatic drainage facilitates fracture healing. Furthermore, we identified that lymphatic platelet thrombosis (LPT) blocked the draining lymphoid sinus and LVs, caused LDI, and then inhibited fracture healing, which can be rescued by a pharmacological approach. Moreover, unblocked lymphatic drainage decreased neutrophils and increased M2-like macrophages of the hematoma niche to support osteoblast (OB) survival and bone marrow-derived mesenchymal stem cell (BMSC) proliferation via transporting damage-associated molecular patterns (DAMPs). Lymphatic platelet thrombolysis also benefits senile fracture healing. These findings demonstrate that LPT limits bone regeneration by impeding lymphatic transporting DAMPs. Together, these findings represent a novel way forward in the treatment of bone repair.

2024-10-05 | PXD056584 |

Lymphatic platelet thrombosis inhibits fracture healing by decreased lymphatic transporting DAMPs in mice

Project description:Lymphatic vessels (LVs) interdigitated with blood vessels, travel and form an extensive transport network in the musculoskeletal system. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, by near infrared indocyanine green lymphatic imaging (NIR-ICG), we examined lymphatic drainage function at the tibial fracture sites and found lymphatic drainage insufficiency (LDI) occurred as early as two weeks after fracture. Sufficient lymphatic drainage facilitates fracture healing. In addition, we identified that lymphatic platelet thrombosis (LPT) blocks the draining lymphoid sinus and LVs, caused LDI and then inhibited fracture healing, which can be rescued by a pharmacological approach. Moreover, unblocked lymphatic drainage inhibits neutrophils influx and induce M2-like macrophages palarization of hematoma niche to support osteoblast (OB) survival and bone marrow-derived mesenchymal stem cell (BMSC) proliferation via transporting damage-associated molecular patterns (DAMPs). These findings demonstrate that LPT limits fracture healing by blocking lymphatic drainage from transporting DAMPs. Together, these findings represent a novel way forward in the treatment of bone fracture healing.

2023-08-28 | PXD044917 |

Indocyanine green (ICG) application to intraoperative navigation of fluorescence imaging

Project description:Interventions: Indocyanine green (ICG) Primary outcome(s): Adverse event Study Design: Single arm Non-randomized

| 2637161 | ecrin-mdr-crc

Indocyanine green fluorescence imaging for assessing risk factors of anastomotic leakage after colorectal cancer surgery

Project description:Interventions: To assess the blood flow at anastomotic site by comparing a direct vision with that under near infrared light after intravenous infusion of indocyanine green. Primary outcome(s): Is it effective or not to assess blood flow at anastomotic site by indocyanine green fluorescent imaging? Study Design: Single arm Non-randomized

| 2646655 | ecrin-mdr-crc

Monocentric Prospective Pilot Study Evaluating the Value of Indocyanine Green (ICG, Indocyanine Green) During a Surgical Resection of Cancerous Lesions Peritoneal Colorectal Origin.

Project description:Between 30% and 40% of patients with colorectal cancer develop metastatic disease intraperitoneally. The optimal treatment of this disease combines surgery and chemotherapy but requires resection of all lesions larger than 2mm. Indocyanine green has an affinity for tumor tissues and the interest of its use has been demonstrated for the detection of sentinel lymph node and some liver surgeries. The ability of indocyanine green to detect peritoneal carcinomatosis in humans has never been evaluated. This study aims to evaluate the diagnostic performance of fluorescence in the detection of malignant cells in peritoneal carcinomatosis of colorectal origin compared with pathological analysis.

| 2154646 | ecrin-mdr-crc

Endoscopic Submucosal Injection of Indocyanine Green Before Laparoscopic Radical Resection for Colorectal Cancer

Project description:Prospective registry study of endoscopic submucosal injection of indocyanine green before laparoscopic radical resection for colorectal cancer

| 2325338 | ecrin-mdr-crc

Prospective Study of Laparoscopic Navigation Surgery with using Indocyanine green-labelled Omental Appendices

Project description:Interventions: ICG-labelled omental appendices Primary outcome(s): Detection rate of indocyanine green-labelled omental appendices Study Design: Single arm Non-randomized

| 2646901 | ecrin-mdr-crc

A Study to Evaluate the Efficacy and Safety of Local administration of Indocyanine Green in Surgery for Colorectal Neoplasm

Project description:Interventions: Off-label use of indocyanine green for detecting sentinel lymph nodes during surgery of colorectal cancer;indocyanine green Primary outcome(s): Rate of subjects with resection line changed from baseline due to ICG fluorescence Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

| 102937 | ecrin-mdr-crc

Application of Near Infrared-Indocyanine Green Imaging System in Robot/Laparoscopic Colorectal Cancer Surgery: A Single Center, Prospective Controlled Trial

Project description:Interventions: experimental group:application of near infrared-indocyanine green imaging system;Control group:Not use near infrared-indocyanine green imaging system Primary outcome(s): Number of lymph nodes detected and positive rate;Perfusion of anastomosis;Anastomotic leakage;Navigation of vessels and structures Study Design: Non randomized control

| 2686729 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data