Browse
Submit Data
Databases
API
Help

Dataset Information

6 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Phase ll study of Panitumumab for advanced colorectal cancer which has prior therapy of Bevacizumab

ABSTRACT: Interventions: FOLFOX+Panitumumab repeat every 14 days until discontinuance criteria. FOLFIRI+Panitumumab repeat every 14 days until discontinuance criteria. Primary outcome(s): Response Rate:RR Study Design: Parallel Non-randomized

DISEASE(S): Metastatic Colorectal Cancer

PROVIDER: 2620619 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

phase II study of panitumumab with irinotecan as third-line treatment for advanced colorectal cancer patients

Project description:Interventions: Panitumumab+CPT-11 repeat every 14 days until discontinuance criteria. Primary outcome(s): Response Rate:RR Study Design: Single arm Non-randomized

| 2620620 | ecrin-mdr-crc

Phase II study of panitumumab with FOLFOX or FOLFIRI as 1st line treatment in patients with metastatic colorectal cancer in Japan

Project description:Interventions: The investigators choose the treatment A or Barbitrarily. A: FOLFOX + panitumumab B: FOLFIRI + panitumumab Repeat every 14 days until meeting the withdrawal criteria. Primary outcome(s): Overall response rate (ORR) Study Design: Single arm Non-randomized

| 2620434 | ecrin-mdr-crc

Panitumumab re-challenge strategy for liquid RAS mutation negative metastatic colorectal cancer

Project description:Interventions: Panitumumab 6 mg / kg and irinotecan 150 mg / m 2 are administered once every two weeks (14 days) until it meets protocol termination criteria. Primary outcome(s): Objective response rate:ORR (Investigator’s judgment based on RECIST guideline ver. 1.1) Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

| 2614266 | ecrin-mdr-crc

Multicenter phase II trial of panitumumab plus irinotecan and S-1 (PIRIS regimen) in patients treated by oxaliplatin-based chemotherapy with K-RAS wild-type advanced colorectal cancer.

Project description:Interventions: Take care of skin before the PIRIS regimen (moistureizer,sunscreen,steroid, antibiotic). Day1/Day15 panitumumab 6mg/kg irinotecan 125mg/m2 Day1~14 S-1 80-120mg/m2 q4w(until progressive disease) Primary outcome(s): Response ratte : RR Study Design: Single arm Non-randomized

| 2620021 | ecrin-mdr-crc

MicroRNA expression profiling identified miR-31-5p/3p as associated with time to progression in wild-type KRAS metastatic colorectal cancer treated with cetuximab but not panitumumab

Project description:The aim of our study was to investigate whether miRNAs could serve as predictive biomarkers to anti-EGFR therapy (cetuximab, panitumumab) in patients with KRAS wild-type (wt-KRAS) metastatic colorectal cancer (mCRC). In our study, historical cohort of 96 patiens with wt-KRAS mCRC (2006-2009) was included and further divided into exploratory and validation cohorts. Large-scale miRNAs expression profiling was performed on the exploratory cohort of 41 wt-KRAS mCRC patients treated with cetuximab to identify miRNAs associated with time to progression (TTP). The validation was performed on two independent cohorts: 30 patients of wt-KRAS mCRC treated with cetuximab and 25 patients of wt-KRAS mCRC treated with panitumumab.

2016-05-05 | E-MTAB-3548 | biostudies-arrayexpress

A study of panitumumab, oxaliplatin, fluorouracil and l-leucovorine as first-line treatment in patients with KRAS wild-type metastatic colorectal cancer. (PANORAMA study)

Project description:Interventions: FOLFOX+Pmab is repeated every 14 days until meeting the withdrawal criteria. Primary outcome(s): Overall Response Rate Study Design: Single arm Non-randomized

| 2621394 | ecrin-mdr-crc

Effective and safe examination of the mFOLFOX6/panitumumab combination therapy for the purpose of hepatectomizing in patients with KRAS Wild-type advanced colorectal cancer which has unresectable liver metastases - Phase II study -

Project description:Interventions: mFOLFOX6+Pmab is repeated every 14 days until meeting the withdrawal criteria. Primary outcome(s): Overall Response Rate Study Design: Single arm Non-randomized

| 2627040 | ecrin-mdr-crc

SOAC1701

Project description:Interventions: Repeat administration until the following regimen falls into the 28 days as one course and falls under the criteria for discontinuation of study treatment. TAS - 102 is administered for 2 consecutive days after a continuous oral administration for 5 days twice a day after dinner and meal, with the prescribed dosage adjusted to body surface area. Repeat this 2 times and then take a rest for 14 days. Repeat administration with this as a course. Incidentally, weight reduction is made according to the condition of the patient. Infusing Bevacizumab intravenously over the course of 90 minutes on Day 1, Day 15. Primary outcome(s): Progression Free Survival Study Design: single arm study, open(masking not used), no treatment control/standard of care control, single assignment, treatment purpose

| 2614186 | ecrin-mdr-crc

Gene expression associated with panitumumab efficacy in squamous cell carcinoma of head and neck

Project description:Platinum-based chemotherapy plus cetuximab, an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody (Mab), is usually offered to recurrent/metastatic (R/M) head-neck squamous cell carcinoma (HNSCC) patients, with only a small portion experiencing durable responses. The anti-EGFR-Mab panitumumab, was used as single agent in platinum pre-treated R/M-HNSCC patients in a phase II trial (PANI01). By analyzing gene expression profiles of a selected retrospective series of HNSCC patients treated with cetuximab, an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody (MAb), associated to chemotherapy, we were able to propose that long progression-free survival (PFS) cases consistently belong to defined molecular subtypes, such as Cluster3-hypoxia and Basal subtypes, respectively defined by De Cecco et al [DeCecco; Oncotarget, 2015] and Keck et al [Keck; CCR,2015], while short-PFS cases are characterized by an over-activation of RAS signaling

2019-01-23 | GSE102995 | GEO

Phase II study of Bevacizumab with SOX (S-1 plus L-OHP) as second-line therapy in metastatic colorectal cancer

Project description:Interventions: Bevacizumab with SOX (S-1 plus L-OHP) repeat every 21 days until discontinuance criteria. Primary outcome(s): Response Rate Study Design: Single arm Non-randomized

| 2620638 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data