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Study of the best epidural catheter location in ERAS protocol as perioperative medical care in rectum/sigmoid colon surgery

ABSTRACT: Interventions: Place the epidural catheter in the lower-thoracic level Place the epidural catheter in the mid-thoracic level Primary outcome(s): effect of postoperative analgesia and gastrointestinal recovery Study Design: Parallel Randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2620919 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A study to compare two different modes of pain relief techniques (continuous delivery of Lidocaine (a pain killer) through the vein and epidural infusion(delivery of pain killer around the layers of spinal cord) in all patients undergoing keyhole surgery for colon cancer

Project description:Intervention1: Lidocaine: Administered intravenously as 2mg/kg bolus followed by infusion at 2mg/kg/hr from the start of surgery till 30 minutes after surgery Control Intervention1: Thoracic Epidural Analgesia: Thoracic Epidural Catheter is inserted at T8-T9 level through which 0.25% Bupivacaine with 1mcg/cc Fentanyl is administered as an infusion for 48 hours post operatively Primary outcome(s): Postoperative pain score at various intervals using Visual Analogue Score(VAS)Timepoint: 2,4,8,12,24 hours post operative

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2020-05-11 | GSE138637 | GEO

RNA-sequencing of Imiquimod-induced rat skin treated with or without epidural lidocaine injection

Project description:We use back skin of WT SD rats, or imiquimod(IMQ)-induced psoraisis-like rat model treated with or without epidural injection of 1% lidocaine. We isolate total RNA for RNA-sequencing.

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