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Observation study for availability of phone support service for management of Capecitabine in patients with Colorectal Cancer(XTRA study)

ABSTRACT: Primary outcome(s): Safety(grade3 of Hand-Foot Syndrome)

DISEASE(S): Colorectal Cancer

PROVIDER: 2623310 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Observation study for availability of phone support service for management of Capecitabine in patients with Colorectal Cancer(XTRA study)

Project description:Primary outcome(s): Safety(grade3 of Hand-Foot Syndrome)

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Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine for Advanced Colorectal Cancer or Breast Cancer

Project description:RATIONALE: Pyridoxine (vitamin B6) may prevent or lessen hand-foot syndrome caused by chemotherapy. It is not yet known whether pyridoxine is more effective than a placebo in preventing hand-foot syndrome. PURPOSE: This phase III randomized trial is studying pyridoxine to see how well it works compared to a placebo in preventing hand-foot syndrome in patients who are receiving capecitabine for advanced colorectal cancer or breast cancer.

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Treatment of Hand and Foot Syndrome With Traditional Chinese Medicine Formula LC09 in Patients Who Are Receiving Capecitabine for Colorectal and/or Breast Cancer

Project description:RATIONALE: Hand foot syndrome may be treated or reduced by soaking Traditional Chinese Medicine Formula LC09 in patients receiving capecitabine for colorectal and/or breast cancer. PURPOSE: This randomized phase III trial is studying soaking Traditional Chinese Medicine Formula LC09 to see how well they work compared to placebos in preventing hand-foot syndrome in patients who are receiving capecitabine for colorectal or breast cancer.

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MicroRNA of exosome in Hand, foot and mouth disease serum samples

Project description:The some biomarkers can be found by pairwise comparison. They can distinguish between extremely severe Hand,foot and mouth disease and mild Hand,foot and mouth disease,moreover,they can applied to diagnose extremely severe Hand,foot and mouth disease mild Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.mild Hand,foot and mouth disease,verification by qRT-PCR

2013-11-27 | E-GEOD-52780 | biostudies-arrayexpress

Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast or Colorectal Cancer

Project description:RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with capecitabine may kill more tumor cells. Celecoxib may prevent or lessen hand-foot syndrome caused by capecitabine. PURPOSE: This randomized phase III trial is studying how well celecoxib works in preventing hand/foot syndrome caused by capecitabine in patients with metastatic breast or colorectal cancer.

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A Study of Prophylactic Treatment for Hand-Foot Syndrome in Patients Treated With Oral Xeloda (Capecitabine).

Project description:This 3 arm study will compare the prophylactic effect of topical corticosteroids, Bepantol or placebo on hand-foot syndrome in patients receiving Xeloda for treatment of metastatic breast cancer, metastatic colorectal cancer or adjuvant treatment of colorectal cancer. Patients who have been receiving oral Xeloda for at least 5 days will be randomized to receive prophylactic treatment with either placebo, topical corticosteroids or Bepantol. The anticipated time on study treatment is until disease progression or development of hand-foot syndrome, and the target sample size is 500+ individuals.

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MicroRNA of exosome in Hand, foot and mouth disease serum samples

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The development of new preventive measures and therapeutic methods in the management of hand-foot syndrome by regorafenib

Project description:Interventions: Effectiveness of prevention of hand-foot syndrome associated with Regorafenib by using aluminum chloride and wound dressing Primary outcome(s): Incidence of Grade 3 HFS Study Design: single arm study, open(masking not used), historical control, single assignment, prevention purpose

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The development of new preventive measures and therapeutic methods in the management of hand-foot syndrome by multi-kinase inhibitors regorafenib

Project description:Interventions: 12 weeks /Application of aluminium chloride ointment once a day and application of wound dressing after the presentation of grade 1 hand-foot syndrome Primary outcome(s): Incidence of Grade 3 HFS Study Design: Single arm Non-randomized

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Topical corticosteroid reforms adjuvant capecitabine chemotherapy. (T-CRACC STUDY)

Project description:Interventions: Administration of hydrocortisone topical;Medication Primary outcome(s): Frequency of occurrence of grade 2 or higher hand foot syndrome at the end of adjuvant chemotherapy (3 months after the start of adjuvant chemotherapy) Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, prevention purpose

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