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Preventive effect of pregabalin on oxaliplatin-related neurotoxicity for patients with advanced/recurrent colorectal cancer: a prospective phase 2 study

ABSTRACT: Interventions: Pregabalin is administered during FOLFOX or XELOX therapy. Initial dose:75mg twice daily(150mg/day),increased to 300 - 600mg/day if there was persistent paresthesia or functional impariment(Grade2 or more). Primary outcome(s): Neurotoxicity frequency of accumulation dose 500mg/m2 of L-OHP (Grade2 or more) Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2624861 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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2018-10-24 | PXD007169 | Pride

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