Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Endocytoscopy observation of novel pit structure associated with type IVv pit pattern for colorectal tumor :Pilot study

ABSTRACT: Interventions: Endocytoscopy observation Primary outcome(s): Diagnostic ability (sensitivity, specificity, accuracy, positive predictive value, and negative predictive value) for colorectal lesion pathology in adenoma component. Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Lesions

PROVIDER: 2629734 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Study of the usefulness of novel pit structure associated with type IVv pit pattern for colorectal tumor :Pilot study

Project description:Interventions: Magnified endoscopy Primary outcome(s): Diagnostic ability (sensitivity, specificity, accuracy, positive predictive value, and negative predictive value) for colorectal lesion pathology in adenoma component. Study Design: Single arm Non-randomized

| 2629733 | ecrin-mdr-crc

Endocytoscopy and Colorectal Neoplasia

Project description:This will be a feasibility study to evaluate the role of endocytoscopy in classifying colorectal polyps in vivo. The primary outcomes will be to determine the key endocytoscopy image features of neoplastic and non-neoplastic colorectal polyps. The target population will include adult subjects undergoing screening and surveillance colonoscopies.

| 2180845 | ecrin-mdr-crc

Artificial intelligence assisted endocytoscopy in real-time diagnosis of early colorectal cancer

Project description:Interventions: Gold Standard:Pathological test;Index test:1. Endoscopy; 2. Artificial intelligence real-time diagnosis system. Primary outcome(s): Diagnostic accuracy;Sensitivity;Specificity;Positive predictive value;Negative predictive value Study Design: Sequential

| 2725610 | ecrin-mdr-crc

Assessment of additional diagnostic value of endocytoscopy to magnifying chromoendoscopy for colorectal neoplasms

Project description:Interventions: Observatin of sequential magnifying chromoendoscopy and endocytoscopy Primary outcome(s): The diagnostic abilities of predicting massively invasive colorectal cancers by endocytoscopy and magnifying endoscopy. Study Design: Single arm Non-randomized

| 2625370 | ecrin-mdr-crc

Early postoperative treatment versus initial observation in CNS WHO grade 2 and 3 oligodendroglioma: clinical outcomes and DNA methylation patterns

Project description:In the past decades, ample evidence has shown that combined radio-chemotherapy is superior to either radiotherapy or chemotherapy alone in oligodendroglioma. However, the survival benefit comes at the cost of immediate and long-term toxicities. Therefore, deferring postoperative therapy until progression may be a valid option to delay treatment-related side effects. Still, systematic data and reliable predictive biomarkers are limited. In this large retrospective series of oligodendroglioma cases, we could show that early postoperative treatment is not associated with improved PFS and OS while correcting for baseline differences between both groups. In addition, we performed whole-genome DNA methylation analyses and observed a predictive role of certain methylation patterns independent from MGMT promoter methylation status, extent of resection and CNS WHO grade. The results of this real-life study may serve as a benchmark for future trial planning in oligodendroglioma, and further studies should evaluate the predictive value of DNA methylation profiles.

2022-08-22 | GSE209579 | GEO

Diagnostic value of endocytoscopy in the colorectum: a retrospective analysis

Project description:Primary outcome(s): The diagnostic abilities of predicting massively invasive colorectal cancers by endocytoscopy and magnifying endoscopy.

| 2625667 | ecrin-mdr-crc

Small RNAome profiling from human skeletal muscle: Novel miRNAs and their targets associated with cancer cachexia

Project description:Background: MicroRNAs (miRs) are small non-coding RNAs that regulate gene (mRNA) expression. Although pathological role of miRs have been studied in muscle wasting conditions such as age, obesity, starvation and muscular dystrophy, their roles in Cancer Cachexia CC are still emerging. Objectives: (i) to profile human skeletal muscle expressed miRs; (ii) to identify differentially expressed (DE) miRs between cachectic and non-cachectic cancer patients; (iii) to identify mRNA targets for the DE miRs to gain mechanistic insights and (iv) to investigate if miRs show potential prognostic and predictive value. Methods: 43 cancer patients were included, of which 19 were cachectic cases exhibiting pre-illness weight loss ≥ 5% and 24 non-cachectic cancer controls who were weight stable in the preceding 6 months. Total RNA isolated from muscle biopsies were subjected to next generation sequencing (NGS). Results: 781 miRs were profiled and 82 miRs with read counts of ≥ 5 in 80% of samples were retained for analysis. We identified 7 DE miRs (up-regulated, fold change of ≥1.4 at p< 0.05). Potential mRNA targets for the DE miRs were identified using previously described human skeletal muscle mRNA expression data (n=90) and identified 212 potential mRNA targets. Ingenuity Pathway Analysis identified 41 pathways (p<0.05) including pathways of myogenesis and inflammation. qRT-PCR analysis of representative miRs, showed similar direction of effect (p<0.05) as in NGS. And lastly, we evaluated the identified miRs for prognostic and predictive value. Conclusions: We identified seven novel miRs associated with CC and pathways that are regulated in CC.

2017-01-09 | GSE75473 | GEO

Clinical Efficacy of Endocytoscopy for Gastrointestinal Endoscopy.

Project description:Endocytoscopy (EC) is a contact-type optical endoscope that allows in vivo cellular observation during gastrointestinal endoscopy and is now commercially available not only in Japan but also in Asian, European Union, and Middle Eastern countries. EC helps conduct a highly accurate pathological prediction without biopsy. Initially, EC was reported to be effective for esophageal diseases. Subsequently, its efficacy for stomach and colorectal diseases has been reported. In this narrative review, we searched for clinical studies that investigated the efficacy of EC. EC seems to accurately diagnose gastrointestinal diseases without biopsy. Most of the studies aimed to clarify the relationship between endocytoscopic findings of gastrointestinal neoplasia and pathological diagnosis. Some studies have investigated non-epithelial lesions or diseases, such as inflammatory bowel disease or infectious diseases. However, there are few high-level pieces of evidence, such as randomized trials; thus, further studies are needed.

| S-EPMC8357585 | biostudies-literature

Homo sapiens

Project description:Predictive Value of MicroRNAs in the Progression of Oral Leukoplakias

| PRJNA265196 | ENA

Homo sapiens

Project description:Molecular markers of predictive value associated with low birth weight

| PRJNA132197 | ENA