Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Feasibility study of a short Bevacizumab infusion in patients.

ABSTRACT: Interventions: Bevacizumab is administered in 0.5mg/kg/min. Primary outcome(s): Having onset of hypersensitivity reaction or not Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer,breast Cancer,ovarian Cancer, Lung Cancer, Cervical Cancer

PROVIDER: 2633596 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

A phase II study of a short bevacizumab infusion in patients with metastatic colorectal cancer.

Project description:Interventions: Bevacizumab was given over 30 min at the first time. If patients had no infusion reaction,the time was shortend to 10 min Primary outcome(s): Progression free survival The rate of infusion reaction Study Design: Single arm Non-randomized

| 2640977 | ecrin-mdr-crc

A validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone. (AVOID)

Project description:Interventions: Dexamethasone 13.2mg/body i.v.(day1) Oxaliplatin 130mg/m2 i.v. (day1) Bevaciumab 7.5mg/Kg i.v. (day1) Capecitabine2,000mg/m2,p.o.(day1-14) to be repeated every 3 weeks Primary outcome(s): Hypersensitivity reaction incidence Study Design: Single arm Non-randomized

| 2625136 | ecrin-mdr-crc

Brief Hydrocortisone Infusion Differentially Influences Blood Leukocyte and Monocyte Gene Expression Before and After Endotoxin Administration in Humans (supported by NIH grant GM34695)

Project description:Fourteen human subjects (18-40 years of age) were studied. The control group (saline + LPS [n = 7]) received a 12 hour infusion of saline and the experimental group (cortisol + LPS [n = 7]) received a 12 hour infusion of cortisol (3 µg/kg/min). After 6 hours of saline or cortisol infusion, intravenous lipopolysaccharide (2 ng/kg) was administered to all subjects. Blood samples were collected at -24 hours, 0 hours, 6 hours and 24 hours relative to LPS administration at 0 hours. Leukocytes and monocytes were isolated from these blood samples, total RNA extracted, and microarray analyses performed using Affymetrix Focus GeneChips®.

2010-05-21 | GSE21909 | GEO

Prospective Analysis of Hypersensitivity Reactions to Oxaliplatin

Project description:This research study will examine how often hypersensitivity, or allergic reactions, occur in patients receiving the chemotherapy medication oxaliplatin. Hypersensitivity reactions can vary from a transient skin rash and fever to more severe symptoms such as shortness of breath, chest tightness, and a more severe allergic reaction that can affect blood pressure called anaphylaxis. We will be examining how often hypersensitivity reactions occur and how severe the reactions are when they occur. We will also examine whether there are factors that place people at risk for developing hypersensitivity reactions to oxaliplatin. In an optional portion to this study, we will examine whether allergy skin testing can predict whether someone will develop a hypersensitivity reaction. Participants who develop a moderate to severe allergic reaction to oxaliplatin will be invited to participate in an additional portion of the study examining a desensitization process. This part of the study will examine whether a desensitization process can prevent future hypersensitivity reactions to oxaliplatin in patients who previously developed moderate to severe hypersensitivity reactions and allow therapy with oxaliplatin to continue.

| 2067027 | ecrin-mdr-crc

Comparison of two regimens of total intravenous anaesthesia for time to recovery from anaesthesia.

Project description:Intervention1: ADBIULFAUIPQP: FNRREUIQFNQI;QEIO;EQGBGR Intervention2: propofol and dexmedetomidine: infusion dexmedetomidine @1mcg/kg over 10 min folowed by infusion dexmedetomidine 0.5mcg/kg/hr. infusion propofol 200mcg/kg/min to maintain a BIS of 40-50 Control Intervention1: EWFVUKFVUY: W2VFUYO Control Intervention2: Propofol and Ketamine: INFUSION KETAMINE @1MG/KG OVER 10 MINS FOLLOWED BY INFUSION KETAMINE 0.5MG/KG/HR INFUSION PROPOFOL 200MCG/KG/MIN TITRATED TO MAINTAIN A BIS OF 40-50 Primary outcome(s): Time taken to achieve Modified Aldrete Score of â?¥9 (MeanÂ±SD) using propofol with ketamine or dexmedetomidineTimepoint: postoperative every minute till Modified Adrette Score is more than or equal to 9 Study Design: Randomized, Parallel Group, Active Controlled Trial Method of generating randomization sequence:Computer generated randomization Method of allocation concealment:Sequentially numbered, sealed, opaque envelopes Blinding and masking:Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded

| 2601412 | ecrin-mdr-crc

Investigating delayed-onset Drug Hypersensitivity Reactions Prospectively

Project description:Investigating delayed-onset Drug Hypersensitivity Reactions Prospectively

| PRJNA994263 | ENA

Investigating delayed-onset Drug Hypersensitivity Reactions Prospectively

Project description:Investigating delayed-onset Drug Hypersensitivity Reactions Prospectively

| PRJNA994264 | ENA

Effect of insulin infusion on human skeletal muscle

Project description:To identify insulin responsive genes in humans, in the first protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a two-hour of hyperinsulinaemic (infusion rate 40 mU/m2/min) euglycemic clamp. A variable infusion of glucose (180 g/l) enriched with tritiated glucose (100 μCi/500 ml) maintained euglycemia during insulin infusion, with monitoring of plasma glucose concentration every 5 to 10 min during the basal and clamp periods using an automated glucose oxidation method (Glucose Analyzer 2, Beckman Instruments, Fullerton, CA). In the second protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a 3-hour hyperinsulinemic (infusion rate 40 mU/m2/min) euglycemic clamp in order to increase the effects of insulin on gene expression. A variable infusion of glucose (180 g/l) was used to maintain euglycemia during insulin infusion with monitoring of plasma glucose concentration every 5 to 10 min using an automated glucose oxidation method (Glucose Analyzer 2, Beckman Instruments, Fullerton, CA). Keywords: dose response

2007-03-01 | GSE7146 | GEO

a Pilot Study of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery

Project description:patients who meet the enrollment criteria will be randomized 1:1:1:1 to the different doses of lidocaine or the placebo group. In the lidocaine groups, at the beginning of surgery, lidocaine 0.5mg/kg, 1.0mg/kg, and 1.5mg/kg per hour were continuously infused (using ideal body weight) respectively during the whole procedure. In contrast, the control group was infused with the same dose of normal saline. All the infusion procedures will be stopped at the end of surgery

| 2735240 | ecrin-mdr-crc

Safety evaluation of a short-term infusion of ramucirumab for GI tract cancer patients

Project description:Interventions: To administer ramucirumab in a short period of time Primary outcome(s): Incidence of infusion related reaction (any grade) at the first short-term infusion Study Design: Single arm Non-randomized

| 2644505 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data