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Randomized controlled trial of endoscopic closure vs. non-closure after colon ESD for preventing post-ESD coagulation syndrome and delayed perforation

ABSTRACT: Interventions: Non-closure Endoscopic closure Primary outcome(s): The rate of PECS and delayed perforation Study Design: Parallel Randomized

DISEASE(S): Colorectal Adenoma, Early Colorectal Cancer

PROVIDER: 2642247 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Efficacy of complete clip closure of the mucosal defect after colorectal-ESD : A randomized controlled, multicenter trial (CCC trial)

Project description:Interventions: without clip closure after ESD complete clip closure after ESD Primary outcome(s): Delayed adverse event rates (Post-ESD coagulation syndrome, delayed bleeding, delayed perforation), intention to treat analysis Study Design: Parallel Randomized

| 2654643 | ecrin-mdr-crc

New electrocoagulation system for preventing post-ESD Coagulation syndrome

Project description:Primary outcome(s): Frequency of PECS

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A multicenter prospective study of the efficacy of prophylactic clip closure for prevention of delayed bleeding after colorectal ESD (endoscopic submucosal dissection)

Project description:Interventions: Prophylactic clip closure after colorectal ESD Primary outcome(s): The rate of delayed bleeding after prophylactic clip closure Study Design: Single arm Non-randomized

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Performance of Preoperative Antibiotics for Post-ESD coagulation syndrome

Project description:Interventions: Antibiotics Without antibiotics Primary outcome(s): The rate of post electrocoagulation syndrome after colorectal endoscopic submucosal dissection Study Design: Parallel Randomized

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Effects of prophylactic clip closure versus non-closure after colorectal endoscopic submucosal dissection on postoperative outcomes: A phase III prospective randomized controlled trial

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Neural tube closure defect

Project description:Neural tube closure defect

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Development of a novel endoscopic hemostasis-assisted navigation AI system in the standardization of post-ESD coagulation.

Project description:Background and study aims While gastric endoscopic submucosal dissection (ESD) has become a treatment with fewer complications, delayed bleeding remains a challenge. Post-ESD coagulation (PEC) is performed to prevent delayed bleeding. Therefore, we developed an artificial intelligence (AI) to detect vessels that require PEC in real time. Materials and methods Training data were extracted from 153 gastric ESD videos with sufficient images taken with a second-look endoscopy (SLE) and annotated as follows: (1) vessels that showed bleeding during SLE without PEC; (2) vessels that did not bleed during SLE with PEC; and (3) vessels that did not bleed even without PEC. The training model was created using Google Cloud Vertex AI and a program was created to display the vessels requiring PEC in real time using a bounding box. The evaluation of this AI was verified with 12 unlearned test videos, including four cases that required additional coagulation during SLE. Results The results of the test video validation indicated that 109 vessels on the ulcer required cauterization. Of these, 80 vessels (73.4%) were correctly determined as not requiring additional treatment. However, 25 vessels (22.9%), which did not require PEC, were overestimated. In the four videos that required additional coagulation in SLE, AI was able to detect all bleeding vessels. Conclusions The effectiveness and safety of this endoscopic treatment-assisted AI system that identifies visible vessels requiring PEC should be confirmed in future studies.

| S-EPMC11018392 | biostudies-literature

Transcriptomic characterization of the delayed wound healing response in a diabetic skin humanized mice model

Project description:Previously, we developed a new model of diabetes-induced wound healing impairment in skin-humanized mice models that faithfully recapitulates the major histo-physiological features of such skin repair-deficient condition. Aiming to dissect the molecular mechanisms responsible for the delayed wound closure, global gene expression studies were performed.

2021-02-01 | GSE147890 | GEO

Transcriptome profiling at neural tube closure site

Project description:Maternal diabetes is a teratogen that can lead to neural tube closure defects in the offspring. We therefore sought to compare gene expression profiles at the site of neural tube closure between stage-matched embryos from normal dams, and embryos from diabetic dams. Neurulation-stage mouse embryos at 8.5 days of gestation were used to prepare neural tissue at the anterior aspect of neural tube closure site 1. Tissue was procured from the open neural tube immediately anterior of the closure site, and from the closed neural tube immediately posterior to the closure site by laser microdissection. For each sample, 10 sections were pooled, total RNA was extracted, and 7 ng of total RNA were used for expression profiling by Tag sequencing using an Applied Biosystems SolidSAGE kit for library construction, and an AB SOLiD 5500 XL instrument for sequencing. Sequence reads were mapped to RefSeq RNA, and count data per gene were obtained using a modified version of the Applied Biosystems SOLiDâ?¢ SAGEâ?¢ Analysis Software. diabetic dam - closed neural tube // diabetic dam - open neural tube // normal dam - closed neural tube // normal dam - open neural tube

2016-10-24 | E-GEOD-41876 | biostudies-arrayexpress

MicroRNA Regulation of Oxidative Stress, Proliferation, and Neural Tube Closure

Project description:single-cell sequencing of the mouse cranial region at E8.25 (the start of neural tube closure, at E9.5 (the end of neural tube closure, and of a miR-302 knockout embryo at E9.5 (example of neural tube closure defrect).

2020-09-24 | GSE158449 | GEO

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