A phase II trial of TAS-102 in combination with cetuximab for patients with RAS wild-type metastatic colorectal cancer refractory to previous anti-EGFR antibodies(WJOG8916G)
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ABSTRACT: Interventions: TAS-102 35 mg/m2, orally BID The evening of Day 1 to the morning of Day 6,Evening of Day 8 to the morning of Day 13, every 28 days Cetuximab Initial dose is 400 mg/m2, the subsequent weekly doses are 250 mg/m2
Primary outcome(s): disease control rate
Study Design: Single arm Non-randomized
DISEASE(S): Metastatic Ras Wild Type Colorectal Cancer Which Has Become Refractory Or There Was Intolerance To Chemotherapies (fluoropyrimidine, Irinotecan, Oxaliplatin) And Bevacizumab, And Refractory To Anti-epidermal Growth Factor Receptor(egfr) Antibodies
PROVIDER: 2642425 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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