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Usefulness of forward-viewing radial-array endoscopic ultrasonography for evaluating invasion depth of colorectal neoplasms

ABSTRACT: Interventions: We diagnose the invasion depth by pit pattern and EUS in the same group. Primary outcome(s): The accuracy for invasion depth of colorectal neoplasms Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Neoplasms

PROVIDER: 2643268 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Magnifying chromoscopic colonoscopy versus endoscopic ultrasonography to predict depth of invasion for early colorectal cancer

Project description:Interventions: "A group: MC followed by EUS" for diagnosis of invasion depth From February 2011 to December 2013 "B group: EUS followed by MC" for diagnosis of invasion depth From February 2011 to December 2013 Primary outcome(s): Accuracy rate for invasion depth of early colorectal cancer by MC and EUS Study Design: Cross-over Randomized

| 2620527 | ecrin-mdr-crc

Chromoendoscopy using the non-extension sign as a marker is comparable to endoscopic ultrasonography in terms of diagnostic performance for evaluating the invasion depth of early colorectal cancer

Project description:Primary outcome(s): To compare diagnostic performance (sensitivity, specificity, and accuracy) for evaluating the invasion depth of T1b cancer between CE using the NES as a marker and EUS.

| 112567 | ecrin-mdr-crc

The retrospective study to examine the usefulness of IMP3 immunostaining for tissue diagnosis and the diagnosis of invasion depth in colorectal neoplasm

Project description:Primary outcome(s): Tissue diagnostic accuracy rate and invasion depth accuracy rate of IMP3 immunostaining

| 2652558 | ecrin-mdr-crc

Comparison of diagnostic accuracy with narrow band imaging colonoscopy and endoscopic ultrasound for differentiation of submucosal invasive colorectal cancer

Project description:Interventions: Procedure/Surgery : To perform and compare the accuracy of both NBI and EUS at of colorectal cancer of subject Primary outcome(s): accuracy of assessment of NBI and EUS for depth of submucosal invasion

| 2510142 | ecrin-mdr-crc

Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI

Project description:Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating invasion depth remains to be verified.The study is based on the hypothesis:NBI can predict histology and invasion depth,combined with the verification of microvessel count and MMP-7 expression.

| 2159618 | ecrin-mdr-crc

Establishment and Verification of Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration of New Diagnostic Methods

Project description:Interventions: Gold Standard:Definite diagnosis by pathology;Index test:Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration. Primary outcome(s): Endoscopic characteristics;SEN, SPE, ACC, AUC of ROC Study Design: Sequential

| 2701950 | ecrin-mdr-crc

Endoscopic Ultrasonography Miniature Probe Performance for Depth Diagnosis of Early Gastric Cancer with Suspected Submucosal Invasion.

Project description:Background/Aims:The accurate assessment of the depth of invasion of early gastric cancer (EGC) is critical to determine the most appropriate treatment option. However, it is difficult to distinguish shallow submucosal (SM1) invasion from deeper submucosal (SM2) invasion. We investigated the diagnostic performance of endoscopic ultrasonography (EUS) using a miniature probe for EGC with suspected SM invasion. Methods:From April 2008 to June 2018, EGCs with suspected SM invasion were analyzed retrospectively. The EGCs examined by a 20 MHz high-frequency miniature probe was included in our study. Esophago-gastric junction cancers and patients treated by chemotherapy before resection were excluded. The sensitivity and specificity for the detection of SM2 invasion by EUS were compared with those of white light imaging (WLI). Additionally, factors related to depth underestimation or overestimation were investigated using multivariate analysis. Results:A total of 278 EGCs in 259 patients were included in the final analysis. The sensitivity and specificity for SM2 or deeper by EUS were 73.7% (87/118) and 74.4% (119/160), respectively. The sensitivity and specificity by WLI were 47.5% (56/118) and 68.1% (109/160), respectively. The sensitivity of EUS was significantly superior to that of conventional endoscopy (p<0.01). Multivariate analysis revealed that an anterior location of the EGC was an independent risk factor for underestimation by EUS (odds ratio, 3.3; 95% confidence interval, 1.1 to 9.8; p=0.03). Conclusions:The depth diagnostic performance for EGCs with suspected SM invasion using EUS was satisfactory and superior to that of conventional endoscopy. Additionally, it is important to recognize factors that may lead to misdiagnosis in those lesions.

| S-EPMC7492497 | biostudies-literature

Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion

Project description:In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring the pregnancy and ensuring adequate blood flow to the fetus. Appropriate depth is critical. Shallow invasion increases the risk of pregnancy complications, e.g., severe preeclampsia. Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of pre-term delivery, hemorrhage and death. Previously a rare condition, the incidence of PAS has increased to 1:731 pregnancies, likely due to the rise in uterine surgeries (e.g., Cesarean sections). CTBs track along the scars deep into the myometrium and beyond. Here we compared the global gene expression patterns of CTBs from PAS cases to gestational age-matched control cells that invaded to the normal depth from preterm birth (PTB) deliveries. The mRNA encoding the guanine nucleotide exchange factor, DOCK4, mutations of which promote cancer cell invasion and angiogenesis, was the most highly differentially expressed molecule in PAS samples. Over-expression of DOCK4 increased CTB invasiveness, consistent with the PAS phenotype. Also, this analysis identified other genes with significantly altered expression in this disorder, potential biomarkers. These data suggest that CTBs from PAS cases up regulate a cancer-like pro-invasion mechanism, suggesting molecular as well as phenotypic similarities in the two pathologies.

2019-09-30 | GSE136048 | GEO

Contrast-enhanced ultrasonography promotes differential diagnosis of ureteral neoplasms.

Project description:ObjectiveTo compare the diagnostic value of contrast-enhanced ultrasonography (CEUS) with baseline ultrasound (B-US) in ureteral neoplasms.MethodsRetrospective analysis, comprising clinical presentation, image appearances, and diagnostic results on B-ultrasound and CEUS, considering pathological result as a gold-standard, was conducted on the clinical information of 39 patients with ureteral neoplasms. CT urography was used to detect and confirm the presence of ureteral neoplasms. Both B-ultrasound and CEUS investigations of those 39 patients under study were performed by a senior radiologist.ResultsPathological outcomes established 27 ureteral malignancies and 12 ureteral benignancies. Ureteral malignancies were observed to occur in older patients than benignancies (p = 0.002). Only the morphological indicator of the ureteric wall on B-ultrasound was different in ureteral malignancies and benignancies (p = 0.030). Tumors with hyperenhancement, larger width, and hyperenhanced ureteric wall were easily diagnosed as malignant on CEUS, whereas iso-/hypoenhanced, narrower, and iso-/hypoenhanced ureteric wall indicated benign tumors. Moreover, the lesion widths, enhanced morphologies of the ureteric wall, and the ureteral wall's linear boundaries on CEUS were different between high- and low-stage ureteral urothelial carcinomas (p = 0.012, 0.002, 0.001, respectively).ConclusionThe display of microvessels in ureteral neoplasms was significantly enhanced by CEUS, thus contributing to the differential diagnosis of ureteral neoplasms while assisting the staging of ureteral urothelial carcinoma.Advances in knowledgeThe imaging features of different ureteral neoplasms on CEUS were analyzed in this study. The diagnostic performances of CEUS and B-ultrasound in ureteral urothelial carcinomas were also explored.

| S-EPMC8553196 | biostudies-literature

The safe and efficacy of forward viewing EUS for colorectal tumor

Project description:Interventions: EUS, which is approved for only upper GI diseases, is used for colorectal diseases. Primary outcome(s): Matching of images obtained using forward viewing EUS and pathological evaluation for colorectal tumor Study Design: Single arm Non-randomized

| 2650959 | ecrin-mdr-crc

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