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Prospective Cohort Study to investigate factors affecting Health Related Quality of Life and the Effectiveness of Symptoms Monitoring via Computer-based Health Evaluation System (CHES) in Patients with Metastatic solid cancers during chemotherapy

ABSTRACT: Primary outcome(s): EQ-5D-5L

DISEASE(S): Patients With Metastatic Solid Cancer (gastric Cancer, Colorectal Cancer And Breast Cancer) Scheduled For First Line Chemotherapy (including Molecular Targeted Drug And Immune Checkpoint Inhibitor)

PROVIDER: 2644845 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The FRAGILE” Trial: A Randomized Controlled Trial on the Clinical Efficacy of a Multidisciplinary Coordinated Geriatric Ward in Reducing Postoperative Complications in Elderly Pre-Frail, Frail, and Sarcopenic Patients Undergoing Elective Colorectal Cancer Surgery

Project description:Interventions: Group 1: Arm A (experimental): Multidisciplinary geriatric ward Group 2: Arm B (control): Contemporary surgical ward Primary outcome(s): Cost-efficacy, measured as all treatment costs, on the 1st to 30th days post-op, divided by the quality-adjusted life-years for the first 30 days post-op, based on the EQ-5D-5L assessed at discharge and extrapolated forward and backward across the month. Study Design: Allocation: Randomized controlled study; Masking: Blinded (masking used); Control: Other; Assignment: parallel; Study design purpose: treatment

| 2436120 | ecrin-mdr-crc

Single cell RNA-seq data of human hESCs comparing experiments with cDNA library equalization

Project description:Considerable effort has been devoted to refining experimental protocols having reduced levels of technical variability and artifacts in single-cell RNA-sequencing data (scRNA-seq). We here present evidence that equalizing the concentration of cDNA libraries prior to pooling, a step not consistently performed in single-cell experiments, improves gene detection rates, enhances biological signals, and reduces technical artifacts in scRNA-seq data. In this submission the original single-cell cDNA is from GSE75748 cells labelled EC2 and TB2 in which the cDNA was not equalized prior to library preparation. We performed a set of experiments with the equalization step and provide three count matrices - 1) EQ (equalized cDNA prior to pooling in equal amounts); 2) EQ Vary (same as EQ but pooled at unequal amounts); 3) EQ-75% (equalized cDNA and pooled equally, sequeced to lower total depth).

2021-11-03 | GSE156494 | GEO

Computer vision syndrome-related symptoms in presbyopic computer workers.

Project description:PurposeTo evaluate the prevalence of computer vision syndrome (CVS)-related symptoms in a presbyopic population using the computer as the main work tool, as well as the relationship of CVS with the electronic device use habits and the ergonomic factors.MethodsA sample of 198 presbyopic participants (aged 45-65 years) who regularly work with a computer completed a customised questionnaire divided into: general demographics, optical correction commonly used and for work, habits of electronic devices use, ergonomic conditions during the working hours and CVS-related symptoms during work performance. A total of 10 CVS-related symptoms were questioned indicating the severity with which they occurred (0-4) and the median total symptom score (MTSS) was calculated as the sum of the symptoms.ResultsThe MTSS in this presbyopic population is 7 ± 5 symptoms. The most common symptoms reported by participants are dry eyes, tired eyes and difficulties in refocusing. MTSS is higher in women (p < 0.05), in laptop computer users (p < 0.05) and in teleworkers compared to office workers (p < 0.05). Regarding ergonomic conditions, MTSS is higher in participants who do not take breaks while working (p < 0.05), who have an inadequately lighting in the workspace (p < 0.05) and in the participants reporting neck (p < 0.01) or back pain (p < 0.001).ConclusionThere is a relationship between CVS-related symptoms, the use of electronic devices and the ergonomic factors, which indicates the importance of adapting workplaces, especially for home-based teleworkers, and following basic visual ergonomics rules.

| S-EPMC10133911 | biostudies-literature

Project description:EQ.118.130124

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Thai cannabis practice patterns and quality of life study

Project description:Interventions: Subjects receive the prescribed Thai Cannabis Oil using the regimen at the discretion of the Thai traditional medicine practitioners. The practice patterns are recorded.;Supportive Care;Thai Cannabis Oil Primary outcome(s): Quality of Life Visit 0, 1, 2, 3 (monthly) Edmonton Symptom Assessment Scale (ESAS),Quality of Life Visit 0, 1, 2, 3 (monthly) ED-5D-5L

| 2568450 | ecrin-mdr-crc

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