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Indocyanine green fluorescence imaging for assessing risk factors of anastomotic leakage after colorectal cancer surgery

ABSTRACT: Interventions: To assess the blood flow at anastomotic site by comparing a direct vision with that under near infrared light after intravenous infusion of indocyanine green. Primary outcome(s): Is it effective or not to assess blood flow at anastomotic site by indocyanine green fluorescent imaging? Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2646655 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates

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Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia

Project description:Background: Clinical failure of arteriovenous fistulae (AVF) is frequently due to juxta-anastomotic neointimal hyperplasia (JANIH). Although the mouse AVF model recapitulates human AVF maturation, previous studies focused on the outflow vein distal to the anastomosis. We hypothesized that the juxta-anastomotic area (JAA) has increased NIH compared to the outflow vein. Method: AVF were created in C57BL/6 mice without or with chronic kidney disease (CKD). Temporal and spatial changes of the JAA were examined using histology and immunofluorescence. Computational techniques were used to model the AVF. RNA-seq and bioinformatic analyses were performed to compare the JAA with the outflow vein. The jugular vein to carotid artery AVF model was created in Wistar rats. Result: The neointima in the JAA shows increased volume compared to the outflow vein. Computational modeling shows increased volume of disturbed flow at the JAA compared to the outflow vein. Endothelial cells are immediately lost from the wall contralateral to the fistula exit, followed by thrombus formation and JANIH. Gene Ontology (GO) enrichment analysis of the 1862 differentially expressed genes (DEG) between the JANIH and the outflow vein identified 525 overexpressed genes. The rat jugular vein to carotid artery AVF showed changes similar to the mouse AVF. Conclusion: Disturbed flow through the JAA correlates with rapid endothelial cell loss, thrombus formation, and JANIH; late endothelialization of the JAA channel correlates with late AVF patency. Early thrombus formation in the JAA may influence later development of JANIH.

2023-12-08 | GSE249267 | GEO

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2023-02-17 | PXD038780 | Pride

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