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The efficacy and safety of Multi Loop Traction Device for colorectal ESD: a single center randomized control trial

ABSTRACT: Interventions: normal colorectal ESD colorectal ESD with MLTD Primary outcome(s): resection time (from the start of resection to the end of resection) Study Design: Parallel Randomized

DISEASE(S): Colorectal Tumor

PROVIDER: 2661025 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Evaluation of utility and safety of endoscopic submucosal dissection using multi loop traction device for early colorectal cancer-single center prospective observational study-

Project description:Primary outcome(s): Endoscopic findings (visual type, localization, size) Details of the endoscopic treatment (operator, ESD knife, contents of the injection solution, treatment time) Adverse event

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Efficacy and Safety of Multi Loop Traction Device-assisted Colorectal Endoscopic Submucosal Dissection: A Multicenter, Randomized Clinical Trial

Project description:Interventions: 1) MLTD-ESD group Colorectal endoscopic submucosal dissection (ESD) is performed using the Multi Loop Traction Device (MLTD). The number of MLTD used in a single session is not limited. The conversion of the allocated therapeutic method is permitted. If the MLTD is ineffective for more than 10 minutes, the MLTD can be removed. 2) Conventional ESD group ESD is completed using a standard therapeutic strategy that does not involve the use of traction devices. The conversion of the allocated therapeutic method is permitted. The MLTD can be used if the endoscopist determines that the traction device has been required for more than 10 minutes. Primary outcome(s): Dissection speed (area resected [mm^2]/duration in minutes) Study Design: Parallel Randomized

| 2724553 | ecrin-mdr-crc

Transcription profiling by array of mouse embyronic stem cells and ESD-EpiSCs

Project description:The comparison of mouse ESCs and ESD-EpiSCs was done using three biological replicates for each cell type. ESC samples (ESR1 p10, p20, ESR1/E p15) and ESD-EpiSC samples (EpiSC-7 p20, EpiSC-5 p22, and EpiSC-7 p25) were used for microarray analysis. Total RNA was extracted using Trizol and labeled and hybridized to Agilent Whole Mouse Genome Oligo 4X44K Microarrays (one-color platform) according to the manufacturers protocols.

2010-05-12 | E-MEXP-2691 | biostudies-arrayexpress

Multi-loop traction device facilitates gastric endoscopic submucosal dissection: ex vivo pilot study and an inaugural clinical experience.

Project description:BackgroundEndoscopic submucosal dissection (ESD) is technically difficult and requires considerable training. The authors have developed a multi-loop traction device (MLTD), a new traction device that offers easy attachment and detachment. We aimed to evaluate the utility of MLTD in ESD.MethodsThis ex vivo pilot study was a prospective, block-randomized, comparative study of a porcine stomach model. Twenty-four lesions were assigned to a group that undertook ESD using the MLTD (M-ESD group) and a group that undertook conventional ESD (C-ESD group) to compare the speed of submucosal dissection. In addition, the data of consecutive 10 patients with eleven gastric lesions was collected using electronic medical records to clarify the inaugural clinical outcomes of gastric ESD using MLTD.ResultsThe median (interquartile range) speed of submucosal dissection in the M-ESD and C-ESD groups were 141.5 (60.9-177.6) mm2/min and 35.5 (20.8-52.3) mm2/min, respectively; submucosal dissection was significantly faster in the M-ESD group (p < 0.05). The rate of en bloc resection and R0 resection was 100% in both groups, and there were no perforation in either group. The MLTD attachment time was 2.5 ± 0.9 min and the MLTD extraction time was 1.0 ± 1.1 min. Clinical outcomes of MLTD in gastric ESD were almost the same as those of ex vivo pilot study.ConclusionsMLTD increased the speed of submucosal dissection in ESD and was similarly effective when used by expert and trainee endoscopists without perforation. MLTD can potentially ensure a safer and faster ESD.

| S-EPMC8740506 | biostudies-literature

A randomized controlled trial about the efficacy of colorectal ESD using a scissors-type knife with traction device for early colorectal neoplasms

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Examination of the colorectal endoscopic submucosal dissection (ESD) with traction device which made easy to resect the colorectal tumors.

Project description:Interventions: endoscopic clip Primary outcome(s): Check for expended hours and success rate of en block resectionin of the ESD. Study Design: Single arm Randomized

| 2623525 | ecrin-mdr-crc

Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD

Project description:Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD

| PRJNA716320 | ENA

Triple-loop clip for the traction-assisted colorectal endoscopic submucosal dissection: multidirectional triple-loop traction method.

Project description: Not available

| S-EPMC7806497 | biostudies-literature

Application value of orthodontic rubber band traction technology in the cultivation of trainee of colorectal ESD

Project description:Interventions: Colorectal beginner ESD using the ORB group, colorectal beginner traditional ESD, expert group traditional ESD group:The orthodontic band was used for traction Primary outcome(s): Operating time Study Design: Parallel

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Efficacy of traction assisted endoscopic submucosal dissection using clip and line for colorectal neoplasms: a randomized controlled trial

Project description:Interventions: Conventional ESD group Traction assisted ESD group Primary outcome(s): ESD procedure time which is measured from the start of the submucosal injection until removal of the lesion Study Design: Parallel Randomized

| 2633910 | ecrin-mdr-crc

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