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Association study on organochlorine pollutant and colorectal cancer risk

ABSTRACT: Interventions: Case group:N/A;control group:N/A Primary outcome(s): Organochlorine pollutant;genetic mutations Study Design: Case-Control study

DISEASE(S): Colorectal Cancer

PROVIDER: 2661840 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A case-control study of the association of sleep duration and quality with colorectal cancer

Project description:Interventions: Case group:N/A;Control group:N/A Primary outcome(s): Group odds ratio;95% confidence interval Study Design: Case-Control study

| 82240 | ecrin-mdr-crc

What’s wrong with SwYG? Probing the limits of S. cerevisiae molecular and analytical toolbox

Project description:The construction of powerful cell factories requires extensive remodelling of microbial genomes, entailing many rounds of transformations to perform the large number of desired gene modifications. However, increasing the number of genetic interventions inevitably increases the occurrence of unwanted mutations and effects. Using glycolysis as paradigm, a previous study developed a Saccharomyces cerevisiae strain in which the glycolytic genes, relocalized to a single locus, can be easily swapped by any new design, thereby enabling fast and easy remodelling of the entire pathway. After 27 genetic modifications performed in 43 transformation rounds, the Switchable Yeast Glycolysis (SwYG) strain grew ca. 20% slower than its ancestor with native glycolysis design. Exploring the cause of this slower growth rate, the present study reflects on the genetic and analytical challenges encountered by extensive strain construction programs and provides design guidelines for integration of large constructs in the yeast genome.

2021-12-06 | GSE190122 | GEO

Risk Factors for Postoperative Intensive Care Unit Admission after Colorectal Cancer Surgery

Project description:Interventions: case group:None;control group:None Primary outcome(s): Admission to ICU after surgery Study Design: Case-Control study

| 41218 | ecrin-mdr-crc

Genome wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP

Project description:We conducted GWAS of sporadic CJD, variant CJD, iatrogenic CJD, inherited prion disease, kuru and resistance to kuru despite attendance at mortuary feasts. After quality control we analysed 2000 samples and 6015 control individuals (provided by the Wellcome Trust Case Control Consortium and KORA-gen), for 491032-511862 SNPs in the European study. Association studies were done in each geographical and aetiological group followed by several combined analyses.

| EGAS00000000097 | EGA

Homo sapiens

Project description:International Glioma Case-Control Study

| PRJNA377601 | ENA

International Glioma Case-Control Study

Project description:International Glioma Case-Control Study

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Association Analysis of VEGF Inhibitors with Vascular Calcification: A Retrospective Study of Patients with Colorectal or Renal Cancer Treated with Bevacizumab

Project description:Interventions: Bevacizumab group :none Primary outcome(s): Aortic calcification score on chest/abdominal CT Study Design: Case-Control study

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OCD Collaborative Genetic Association Study

Project description:OCD Collaborative Genetic Association Study

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Myositis

Project description:Idiopathic inflammatory myopathies (polymyositis and dermatomyositis) are heterogeneous group of muscle disorders of unknown etiology.The pathogenic pathways responsible for muscle fiber damage and dysfunction in myositis are not currently well defined. Identification of such pathways may help to design novel therapeutic interventions and also help to develop diagnostic tests. Keywords: Development or differentiation design

2006-07-21 | GSE5370 | GEO

Plasma protein profiling of women after a GDM pregnancy

Project description:Gestational diabetes (GDM) is a distinctive form of diabetes that first presents in pregnancy. While most women return to normoglycemia after delivery, they are predisposed to an accelerated development of type 2 diabetes. Current prevention strategies remain limited due to our incomplete understanding of the early underpinnings of progression. We therefore examined the protein profiles of women shortly after a GDM pregnancy (using a nested case-control study design within the Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy) for a comprehensive mechanistic inquiry. At 6-9 weeks postpartum (baseline), differences between women who later developed diabetes (case group) and those who did not (control group) were detected. Notably, protein profiles comprised protease inhibitors, extracellular matrix components, and lipoprotein molecules involved in inflammation. We also identified co-expression networks of differentially altered triglycerides and protein involved in wound healing, highlighting the interplay between dyslipidemia and inflammation. Overall, our findings warrant earlier intervention than previously thought, as defects in postpartum wound healing after a GDM pregnancy, in association with dysmetabolism and insulin resistance, may accelerate type 2 diabetes progression.

2024-09-04 | PXD041243 | Pride

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