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The correlation study of Platelet Activation and Colorectal Cancer Prognosis

ABSTRACT: Interventions: 1 :post operation follow-up Primary outcome(s): Sex;date of birth;date of diagnosis (dx);?Medical history (especially hematologic disease);drug history (especially aspirin, anti-coagulation;Tumor site;histological type;tumor grade;TNM stage;chemo/radiation;Date of operation;length of hospital stay;post-op complication (especially DVT, cardiovascul;date of visiting or fu;date of recurrence;date of death;cause of death;any cardiovascular events during whole fu;RBC;HGB;HCT;MCV;MCH;MCH;MCHC;RDW-SD;RDW-CV;PLT;WBC;NEUT%;LYMPH%;MONO%;EO%;BASO%;ABN%;ABN%;NEUT#;LYMPH#;MONO#;EO#;BASO#;PT;INR;APTT;APTT%;TT;TT%;FI Study Design: historical control

DISEASE(S): Colorectal Cancer

PROVIDER: 2671436 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Study of the safety of a robot assisted operation using ’da Vinci Xi’ for stomach and colorectal cancer.

Project description:Interventions: A robot assisted operation using ‘da Vinci Xi’ period of ntervention: 5 years Primary outcome(s): 1. Age, sex, height, weight, BMI, PS 2. Past medical history:Health history, operation history 3. laboratory test values 4. pathological classification associated tumor, number of lymph nodes harvested, venous invasion 5. Operative information procedure, reconstruction method, anesthesia time, surgical time, operative bleeding loss, Lymph node dissection number, completed in robot-assisted laparoscopic surgery, the reason of unsuccessful completion 6. Intraoperative and postoperative stomach cancer complication 7. Intraoperative and postoperative colorectal cancer complication 8. presence or absence of post-operation treatment and relapse, post-operation treatment of a therapeutic regimen, survival period, the start time of oral ingestion after operation, postoperative length of stay 9. The number of robot-assisted implemented, analysis of the operation time Study Design: Single arm Non-randomized

| 2639120 | ecrin-mdr-crc

Single cell profiling of primary and paired metastatic lymph node tumors in breast cancer patients(10x RNA and TCR)

Project description:The microenvironment of lymph node metastasized tumors (LNMT) determines tumor progression and response to therapy, but a systematic study of LNMT is lacking. Here, we generate single-cell maps of primary tumors (PTs) and paired LNMTs in 8 breast cancer patients. We demonstrate that the activation, cytotoxicity, and proliferation of T cells are suppressed in LNMT compared with PT. CD4+CXCL13+ T cells in LNMT are more likely to differentiate into an exhausted state. Interestingly, LAMP3+ dendritic cells in LNMT display lower T cell priming and activating ability than in PT. Additionally, we identify a subtype of PLA2G2A+ cancer-associated fibroblasts enriched in HER2+ breast cancer patients that promotes immune infiltration. We also show that the antigen-presentation pathway is downregulated in malignant cells of the metastatic lymph node. Altogether, we characterize the microenvironment of LNMT and PT, which may shed light on the individualized therapeutic strategies for breast cancer patients with lymph node metastasis.

2022-04-30 | GSE167036 | GEO

Single cell profiling of primary and paired metastatic lymph node tumors in breast cancer patients (10x Visium)

2022-04-30 | GSE190811 | GEO

Phosphorylation ratio of pT vs pY ERK in MEK phosphorylation reaction determined by mass spectrometry

Project description:The purpose of this experiment is to determine the phosphorylation ratio of pT vs pY ERK present in ERK phosphorylation reaction by activated MEK E203K or MEK WildType. Aliquots were collected at 3 minutes 15 seconds, the time at which the mono-phosphorylated ERK is at its maximal. To determine the ratio between pT and pY ERK, synthetic AQUA peptides corresponding to the pY- and the pT-phosphorylated ERK were spiked into the sample. The two peptides have identical mass but they can be umabiguguously distinguished by their elution times and fragmentation spectra.

2020-01-14 | PXD016580 | Pride

Photothrombotic Cerebral Stroke as a Model of Post-Stroke Seizures/Epilepsy in aged mice

Project description:Stroke is a prevalent disorder representing the third leading cause of death and major cause of disability. Post-stroke epilepsy (PSE) has been recognized as a common clinical issue after stroke, accounting for 30-40% of the causes of epilepsy among older adults. In this study, we determined GABAA receptor-mediated seizure susceptibility after PT cerebral stroke in aged mice. Young adult mice around 10 weeks of age are widely used in stroke experiments. However, as most strokes are diagnosed in the elderly and PSE has been recognized as a common clinical incidence after stroke, we utilized photothrombosis (PT) model of cerebral ischemia and examined seizure susceptibility and brain injury using combined behavioral (video) and EEG monitoring and histological (MRI) assessments. To investigate GABAA receptor-mediated convulsive/non-convulsive seizures, lower-doses of pentylenetetrazol (PTZ) was injected. PTZ susceptibility in aging mice increased compared to young adults. One month after PT stroke, aged PT stroke mice exhibited severe convulsive seizures (late-onset). These findings exhibited the increase of GABAA receptor-mediated seizures susceptibility in PT stroke aging mice, but not in young adults.

2023-11-27 | GSE241528 | GEO

Gene expression patterns induced by 5-Fluorouracil in breast cancer cell lines

Project description:We have compared the changes in cell cycle and cell death parameters induced by 2 different concentrations of 5-FU (IC50 and IC80) in the breast adenocarcinoma cell line MCF7. G1/S cell cycle arrest was associated with both concentrations, whereas cell death was mainly induced after IC80 5-FU. These changes were correlated with gene expression assessed by cDNA microarray analysis. Main findings included an overexpression of p53 target genes involved in cell cycle and apoptosis (CDKN1A/p21, TP53INP, TNFRSF6/FAS and BBC3/PUMA), and significant repression of Myc. High dose 5-FU also induced a higher regulation of the mitochondrial death genes APAF1, BAK1 and BCL2, and induction of genes of the ID family. Keywords: Dose Response

2006-04-07 | GSE2584 | GEO

Gene expression patterns induced by 5-Fluorouracil in breast cancer cell lines

2010-07-01 | E-GEOD-2584 | biostudies-arrayexpress

Levetiracetam normalized E/I imbalance in the hippocampus after cortical stroke in aged mice

Project description:Stroke is a prevalent disorder representing the third leading cause of death and major cause of disability. Post-stroke epilepsy (PSE) has been recognized as a common clinical issue after stroke, accounting for 30-40% of the causes of epilepsy among older adults. In this study, we determined GABAA receptor-mediated seizure susceptibility after PT cerebral stroke in aged mice. Young adult mice around 10 weeks of age are widely used in stroke experiments. However, as most strokes are diagnosed in the elderly and PSE has been recognized as a common clinical incidence after stroke, we utilized photothrombosis (PT) model of cerebral ischemia and examined seizure susceptibility. To investigate in vitro drug-induced seizure susceptibility (E/I imbalance) of GABAA receptor antagonist, gabazine (GZ), voltage-sensitive dye (VSD) imaging techniques were used in hippocampal brain slices. One month after PT stroke, in vivo aged PT stroke mice exhibited severe convulsive seizures (late-onset). in vitro GZ-induced E/I imbalance in hippocampus of aging mice increased compared to young adults. In addition, Anti-seizure medication (levetiracetam) normalized in vitro GZ-induced E/I imbalance in hippocampus of aging mice. These findings exhibited that GABAA receptor-mediated seizures susceptibility (E/I imbalance) in hippocampus after cortical PT stroke in aging mice, but not in young adults.

2023-11-27 | GSE241525 | GEO

DNA methylome analysis of primary prostate cancer and pathologic lymph node metastases in patients with low and high Gleason score

Project description:DNA-methylation profiles of primary tumors (PT) and paired synchronous lymph node metastases (LN) from Gleason Score (GS)-6/7a (n=20 LN-positive, n=20 LN-negative) and GS-9/10 patients (LN-positive n=20) after prostatectomy and lymphonodectomy were analyzed.

2023-01-23 | GSE220910 | GEO

Characterizing genetic transitions of copy number alterations and allelic imbalances in metastatic process of the oral tongue carcinoma

Project description:Primary tumor heterogeneity can significantly affect the genetic profile of clones at metastatic sites. In order to understand the mechanisms underlying metastasis, we compared the genetic profile of paired primary tumor (PT) and metastatic lymph node (MLN) samples obtained from individual patients.

2016-09-23 | GSE76014 | GEO

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