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Study about immune nutritional therapy accerlerated rehabilitation after colorectal cancer surgery in the Fast Track model

ABSTRACT: Interventions: Group A:Use the conventional enteral nutrition;Group B:Use the immune enhanced enteral nutrition Primary outcome(s): Nutrition Indicators;immune indexes;The acute phase inflammatory reaction index;Barrier function;FT process postoperative rehabilitation index;The safety index FT proces Study Design: Randomized parallel controlled trial

DISEASE(S): Colorectal Cancer

PROVIDER: 2673775 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The effect and mechanism of Si-Jun-Zi decoction on the function of intestinal mucosal barrier during chemotherapy for colorectal cancer

Project description:Interventions: Control:FOLFOX or CAPEOX chemtherapy;Experimental group 1:Si-Jun-Zi decoction;Experimental group 2:enteral nutrition combine with Chemotherapy;Experimental group 3:Si-Jun-Zi decoction + enteral nutrition Primary outcome(s): Intestinal barrier function Study Design: Parallel

| 2689141 | ecrin-mdr-crc

Neonatal antibotic prophylaxis modulates intestinal immunity and prevents necrotizing enterocolitis in preterm neonates

Project description:Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula feeding. Antibiotics (n=11) or control saline (n=13) were given twice daily from birth to tissue collection at d 5. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. We used Affymetrix microarrays to investigate gene expression in intestinal tissues of preterm piglets treated with antibiotics or control saline. Twenty-four preterm piglets were delivered by caesarean section on day 105 of gestation from two healthy sows. All piglets were initially provided with parenteral nutrition via a vascular catheter, combined with small amounts of minimal enteral nutrition. On day three, all parenteral nutrition was stopped and total enteral nutrition was given through an oro-gastric feeding tube. Piglets were allocated into controls ( n=13) and an intervention group receiving oral and systemic broad-spectrum antibiotics ( n=11). To assure high systemic and intra luminal MIC values antibiotics were given both orally and intramuscularly. All antibiotics were given directly after feeding with an oral bolus and control pigs were given corresponding amounts of saline. On day five, all piglets were euthanized, and small intestinal tissue collected.

2013-08-21 | E-GEOD-48125 | biostudies-arrayexpress

The effect of i-feed tool in accurate enteral nutrition management of colorectal cancer during perioperative period

Project description:Interventions: experimental group:accurate enteral nutrition management based on i-feed tool;control group:Routine mission and education evaluation of enteral nutrition Primary outcome(s): Rate of compliance with enteral nutrients;Nutritional indicators: serum albumin (ALB) serum prealbumin (PA) serum transferrin (TF) and BMI;Clinical rehabilitation index: postoperative first anal exhaust time (h) postoperative complication rate Study Design: Parallel

| 2691592 | ecrin-mdr-crc

Safety of fast-track rehabilitation after gastrointestinal surgery: systematic review and meta-analysis.

Project description:To compare the safety of fast-track rehabilitation protocols (FT) and conventional care strategies (CC), or FT and laparoscopic surgery (LFT) and FT and open surgery (OFT) after gastrointestinal surgery.We searched MEDLINE, WHO International Trial Register, Embase and The Cochrane Central Register of Controlled Trials up to 2014 for randomized controlled trials (RCTs) comparing FT and CC or comparing LFT and OFT, with 10 or more randomized participants and about 30 d follow-up. Two reviewers independently extracted data on complications, anastomotic leak, obstruction, wound infection, re-admission between FT and CC or LFT and OFT after gastrointestinal surgery.Twenty-four RCTs of FT vs CC or LFT vs OFT were included. Compared with CC, FT reduced overall complications and wound infection. However, anastomotic leak, obstruction and re-admission were not significantly reduced. The pooled risk ratio (RR) of 0.69 (95%CI: 0.60-0.78; P < 0.001), pooled RR of 0.71 (95%CI: 0.57-0.88; P < 0.001), pooled RR of 0.93 (95%CI: 0.68-1.25; P > 0.05), a pooled RR of 0.87 (95%CI: 0.67-1.15; P > 0.05) and pooled RR of 0.94 (95%CI: 0.73-1.22; P > 0.05) respectively. Compared with OFT, LFT reduced complications, with a pooled RR of 0.66 (95%CI: 0.54-0.81; P < 0.001).FTs are safe after gastrointestinal surgery. Additional large, prospective RCTs should be conducted to establish further the safety of this approach.

| S-EPMC4223277 | biostudies-other

The prospective study of the impact: Fast track model on colorectal cancer patients’ quality of nutrition after surgery

Project description:Interventions: Group A:Fast track rehabilitation management mode;Group B:Traditional process management mode Primary outcome(s): Nutrition Indicators;immune indexe Study Design: Randomized parallel controlled trial

| 2674977 | ecrin-mdr-crc

Genome wide impact of loss of mechanoluminal stimulation on neonatal intestine

Project description:Purpose: Surgical treatment of congenital and neonatal intestinal diseases often requires resection of intestine and/or diverstion of luminal flow. Subsequent growth on enteral nutrition alone depends on adaptation of the remaining bowel. The role of mechanoluminal stimulation in driving intestinal adaptation and the effects of depriving the intestine of mechanoluminal stimulation are unknown. Methods: 5 pairs of intestine from neonatal surgical patients were obtained at ileostomy reversal. The proximal segment contiguous with enteral feeding was denoted “fed” and the distal segment without luminal flow was denoted “unfed". Following RNA extraction, these samples underwent deep sequencing. Results: Fed intestine had increased expression of genes involved in inflammation and immune regulation and steroid secretion. Unfed intestine had increased expression of genes involved in digestion and transport. Conclusion: Independent of external influences, the presence or absence of enteral mechanoluminal stimulation causes significant alterations in gene expression in intestine.

2017-06-01 | GSE82147 | GEO

The effect of nutrient deprivation on early life small intestine mucosal microbiome and host proteome

Project description:Nutrition has a vital role in shaping the intestinal microbiome. The impact of nutrients and the consequences of enteral deprivation on the small intestinal mucosal microbiota, specifically in early life, has not been well described. Our aim was to study the impact of enteral deprivation on the small intestine mucosal microbiome and to search for factors that shape this interaction in early life. Host seem to be the most dominant factor in the structure of the early life mucosal microbial small intestine community. Under conditions of nutrient deprivation, there are specific changes in host proteomics. Further research is needed to better define and understand this host-microbe-nutrition interaction in the small intestine.

2024-07-16 | PXD044961 | Pride

Effect of moxibustion on early enteral nutritional tolerance and intestinal mucosal barrier function in patients with advanced gastric cancer after surgery

Project description:Interventions: experimental group:On the basis of control group, moxibustion treatment was given.Acupuncture point selection: Zusanli, Liangmen and Shangjuxu points on both sides. Moxibustion was started 48h after the operation at the start of enteral nutrition treatment. At 9am every day, moxibustion was performed for 5 minutes at each part, and the duration of moxibustion was about 30 minutes.;control group:Postoperative nursing routine and early enteral nutrition therapy for gastric cancer Primary outcome(s): he incidence of tube feeding intolerance;Intestinal mucosal barrier related factors and infection indicators;Enteral nutritional tolerance score Study Design: Parallel

| 86756 | ecrin-mdr-crc

Early enteral and parenteral nutrition in patients with nutritional risk after gastrointestinal surgery

Project description:Interventions: EEN:Early enteral nutrition;Control:Total parenteral nutrition Primary outcome(s): Albumin,Pre-albumin,body mass index and so on Study Design: Randomized parallel controlled trial

| 2675906 | ecrin-mdr-crc

Fast-track rehabilitation following video-assisted pulmonary sublobar wedge resection: A prospective randomized study.

Project description:BACKGROUND:Postoperative morbidity and inhospital length of stay are considered major determinants of total health care expenditure associated with thoracic operations. The aim of this study was to prospectively evaluate the role of video-assisted thoracic surgery (VATS) compared to mini-muscle-sparing thoracotomy in facilitating early recovery and hospital discharge after pulmonary sublobar wedge resections. PATIENTS AND METHODS:A total number of 120 patients undergoing elective pulmonary sublobar wedge resection were randomly assigned to VATS (n = 60) or mini-muscle-sparing thoracotomy (n = 60). The primary endpoint was time to hospital discharge. Postoperative complications, cardiopulmonary morbidity and 30-day mortality served as secondary endpoints. RESULTS:Patients' baseline demographic and clinical data did not differ among study arms as well as the number of pulmonary segments resected and the morphology of the nodular lesions. Total hospital stay was significantly shorter in patients assigned to the thoracoscopic technique as opposed to those who were operated using the mini-muscle-sparing thoracotomy approach (4 ± 0.6 versus 4.4 ± 0.6 days respectively, P = 0.006). Multivariate analysis revealed that VATS approach was inversely associated with longer inhospital stay whereas the number of resected segments was positively associated with an increased duration of hospitalization. Patients in the VATS group were less likely to develop atelectasis (?1 lobe) compared to those who underwent thoracotomy (0% versus 6.7% respectively, P = 0.042). Kaplan-Meier analysis revealed similar 30-day mortality rates in both study arms (Log-rank P = 0.560). CONCLUSION:VATS was associated with shorter duration of hospitalization positively affecting the patients' quality of life and satisfaction. Significant suppression of the total cost of recovery after thoracoscopic pulmonary resections is expected.

| S-EPMC4916745 | biostudies-literature

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