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Changes of intestinal microbiota before and after operation in patients with colon cancer and its influencing factors

ABSTRACT: Interventions: Case series:operation Primary outcome(s): Intestinal flora Study Design: Randomized parallel controlled trial

DISEASE(S): Colon Cancer

PROVIDER: 2678001 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Changes of intestinal microbiota in patients with colon cancer before and after chemotherapy and study of probiotic intervention.

Project description:Interventions: Chemotherapy +placebo group:placebo; Chemotherapy + Clostridium butyricum capsules group:Clostridium butyricum capsules Primary outcome(s): Intestinal flora;Nutrition index;Immune index Study Design: Randomized parallel controlled trial

| 2678004 | ecrin-mdr-crc

Serology changes before and after the operation of frontal lobe epilepsy, a study based on proteomic approaches

Project description:Frontal lobe epilepsy (FLE) is one common type of epileptic in clinic. Some FLE patients could be cured by surgery treatment. This study is designed to find out if there are some differential protein expressions in serum between pre and post operation of the seizure-free FLE patients. We have utilized proteomic approaches to quantify the proteome of serum from 5 surgery patients who were diagnosed with FLE. The self-control method was used in the study, and serum samples from two time periods, including pre-operation and one year after the surgery were selected. We have found about six hundred proteins in serum, and 14 of them had statistical difference between pre and post operation. 13 proteins including 3 apolipoprotein subtypes (APOA2, APOC1, and APOC2) had a higher expression levels with the other one a lower expression level in the pre-operation group compared to the post-operation group. This method may highlight a potential way to explore refractory epilepsy biomarkers, and some apolipoprotein subtypes may be the potential biomarkers used in the diagnosis of FLE in the future.

2018-06-11 | PXD010079 |

Plasma lncRNA and mRNA profiles in patients with NSCLC: Pre-operation vs. post-operation

Project description:Circulating transcriptional landscapes between pre-operation and post-operation plasma samples were compared using the Arraystar Human LncRNA Microarray V4 with probes for profiling of 40173 human lncRNAs and 20730mRNAs. Goal was to investigate the impact of tumor removal on circulating lncRNA and mRNA expression levels.

2018-12-31 | GSE99870 | GEO

Study for the difference of intestinal microbiota between gastric tumor and intestinal tumor after intestinal preparation and its relationship with postoperative delirium

Project description:Interventions: Case series:Nil Primary outcome(s): intestinal flora;postoperative delirium Study Design: Cohort study

| 2680198 | ecrin-mdr-crc

Correlation between POCD and differential changes in intestinal flora in elderly patients with colorectal surgery

Project description:Interventions: case series:None Primary outcome(s): postoperative cognitive dysfunction;IL-6;IL-1;Gut flora Study Design: Cohort study

| 79854 | ecrin-mdr-crc

Polysaccharides from Sargassum fusiforme protect mice against Citrobacter rodentium infection through intestinal microbiota-drived microRNA-92a-3p

Project description:To explore the regulatory mechanism of intestinal flora in Citrobacter rodentium -induced intestinal infection by transcriptome analysis at miRNA molecular level.

2024-03-04 | GSE260446 | GEO

Establishment of Individualized Immunotherapy Strategy and Platform Based on Changes of Intestinal Microbiota

Project description:To explore and analyze the relationship between intestinal flora changes and the efficacy of individualized immunotherapy in patients with upper gastrointestinal cancer, and to find new biomarkers to predict the efficacy of immunotherapy, bringing new breakthroughs in tumor diagnosis and treatment.

| 2391273 | ecrin-mdr-crc

Molecular Mechanisms Influencing Bacterial Conjugation in the Intestinal Microbiota.

Project description:Bacterial conjugation is a widespread and particularly efficient strategy to horizontally disseminate genes in microbial populations. With a rich and dense population of microorganisms, the intestinal microbiota is often considered a fertile environment for conjugative transfer and a major reservoir of antibiotic resistance genes. In this mini-review, we summarize recent findings suggesting that few conjugative plasmid families present in Enterobacteriaceae transfer at high rates in the gut microbiota. We discuss the importance of mating pair stabilization as well as additional factors influencing DNA transfer efficiency and conjugative host range in this environment. Finally, we examine the potential repurposing of bacterial conjugation for microbiome editing.

| S-EPMC8213034 | biostudies-literature

Continuous airlift operation treating saline oilfield PW

Project description:Continuous airlift operation treating saline oilfield PW

| PRJEB46531 | ENA

Alpha-ketoglutarate (AKG) lowers body weight and affects intestinal innate immunity through influencing intestinal microbiota.

Project description:Alpha-ketoglutarate (AKG), a precursor of glutamate and a critical intermediate in the tricarboxylic acid cycle, shows beneficial effects on intestinal function. However, the influence of AKG on the intestinal innate immune system and intestinal microbiota is unknown. This study explores the effect of oral AKG administration in drinking water (10 g/L) on intestinal innate immunity and intestinal microbiota in a mouse model. Mouse water intake, feed intake and body weight were recorded throughout the entire experiment. The ileum was collected for detecting the expression of intestinal proinflammatory cytokines and innate immune factors by Real-time Polymerase Chain Reaction. Additionally, the ileal luminal contents and feces were collected for 16S rDNA sequencing to analyze the microbial composition. The intestinal microbiota in mice was disrupted with an antibiotic cocktail. The results revealed that AKG supplementation lowered body weight, promoted ileal expression of mammalian defensins of the alpha subfamily (such as cryptdins-1, cryptdins-4, and cryptdins-5) while influencing the intestinal microbial composition (i.e., lowering the Firmicutes to Bacteroidetes ratio). In the antibiotic-treated mouse model, AKG supplementation failed to affect mouse body weight and inhibited the expression of cryptdins-1 and cryptdins-5 in the ileum. We concluded that AKG might affect body weight and intestinal innate immunity through influencing intestinal microbiota.

| S-EPMC5503525 | biostudies-literature

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