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Supplement of Bifico Capsule Alternates Gut Microbiota in Colorectal Cancer Patients Receiving Chemotherapy

ABSTRACT: Interventions: Case series:Bifico Primary outcome(s): Abundance of Clostridium Symbiosum;Abundance of Fusobacterium Nucleatum;survival time Study Design: Case series

DISEASE(S): Colorectal Cancer

PROVIDER: 2679364 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Comparison of Fusobacterium Nucleatum stimulated and unstimulated neutrophils

Project description:Neutrophils are known to be stimulated by different periodontal bacteria to produce reactive oxygen species and cytokines. It is inportant to investigate the gene changes made by bacteria of importance, of which, for periodontal disease, fusobaterium nucleatum is one. we used microarrays to investigate gene experssion changes in peripheral blood neutrophils werwhich e stimulated with or with out Fusobacterium Nucleatum (10953). Neutrophils from periodonatlly healthy individuals (n=4) were isolated and stimulated for 3hrs with or without fusobaterium nucleatum (10953). RNA was then extracted from these and pooled before hybridization on Affymetrix microarrays

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