Browse
Submit Data
Databases
API
Help

Dataset Information

28 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Investigation on Nutrition Status and its Clinical Outcome of Common Cancers

ABSTRACT: Interventions: Case series:Non-intervention Primary outcome(s): Patient Generated-Subjective Global Assessment;Karnofsky Performance Status (KPS) questionnaire;Quality of life questionnaire for cancer patients;Died in the 30 days within this hospitalization;Length of hospital stay;Length of ICU stay;Hospital costs of this hospitalization;Overall survival Study Design: Cohort study

DISEASE(S): Lung Cancer, Gastric Cancer, Liver Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, Cervical Cancer, Endometrial Cancer, Nasopharyngeal Carcinoma, Malignant Lymphoma, Leukemia, Pancreatic,C21, C33-c34, C16,c50,c11,c15,c53, C22,c91-c95,c83,c56,c25,c54,c70-c72,c67,c61

PROVIDER: 2681353 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Impact of malnutrition diagnosed on clinical outcomes of postoperative patients with gastrointestinal tumors

Project description:Interventions: Case series:None Primary outcome(s): Overall survival;Length of hospital stay;Length of ICU stay;Hospital costs of this hospitalization;Infection complications;Non-infectious complications Study Design: Cohort study

| 80798 | ecrin-mdr-crc

Effects of steroids on peripheral blood gene expression in COVID-19 patients according to rs1990760 variants

Project description:Background: Outcomes in patients with severe SARS-CoV-2 infection (COVID-19) are conditioned by viral control and regulation of inflammation. Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. Methods: Patients admitted to an intensive care unit (ICU) with documented COVID-19 were prospectively included and IFIH1 rs1990760 genotypes determined. Peripheral blood gene expression, cell populations and immune mediators were measured during the first day after ICU admission before steroid therapy. Peripheral blood mononuclear cells from healthy volunteers were exposed ex-vivo to an MDA5 agonist and dexamethasone, and changes in gene expression assessed. ICU discharge and hospital death were modelled using rs1990760 variants and dexamethasone therapy as factors. Findings: 237 patients were studied. Patients with the IFIH1 rs1990760 TT variant showed a decrease in expression of inflammation-related pathways, an anti-inflammatory cell profile and a decrease in pro-inflammatory mediators. Cells with TT variant exposed to an MDA5 agonist ex-vivo showed an increase in FOXO3 and IL6 when dexamethasone was added. All patients with the TT variant not treated with steroids (n=14) survived their ICU stay (HR 2.49 95% confidence interval 1.29 – 4.79). Dexamethasone therapy in this subgroup (N=50) delayed ICU discharge and increased hospital mortality (HR 2.19, 95% confidence interval 1.01 – 4.87) and serum IL-6 concentrations. Interpretation: COVID-19 ICU patients with the IFIH1 rs1990760 TT variant show an ameliorated inflammatory response that results in better outcomes than CC/CT variants. Dexamethasone can reverse this anti-inflammatory phenotype, worsening the outcome. Funding: Instituto de Salud Carlos III.

2021-07-03 | GSE177025 | GEO

Peripheral blood gene expression according to IFIH1 rs1990760 variants in critically-ill COVID-19 patients

2021-07-03 | GSE168400 | GEO

The impact of pre-operative education on post-operative outcomes in patients with colorectal cancer in Johannesburg, South Africa

Project description:Interventions: Control group;Intervention group one;Intervention group two Primary outcome(s): ICU length of stay;Survival;Hospital length of stay;Post-operative complications Study Design: Factorial: participants randomly allocated to either no, one, some or all interventions simultaneously,Randomised,Stratified allocation where factors such as age, gender, center, or previous treatment are used in the stratification,Sealed opaque envelopes

| 2507080 | ecrin-mdr-crc

ARDSProfiling

Project description:To investigate immunologic alterations taking place in patients with nosocomial sepsis, we undertook genomic expression analysis of white blood cells (WBC) using DNA microarrays in a small sample of trauma patients who developed severe sepsis/septic shock during their ICU stay and compared with trauma patients with uncomplicated sepsis. RNA was extracted from blood obtained upon admission (a) and at the onset of the disease (b).

2012-08-01 | E-MEXP-3621 | biostudies-arrayexpress

Genome-wide blood transcriptional profiling in critically ill patients - MARS consortium

Project description:The host response in critically ill patients with sepsis, septic shock remains poorly defined. Considerable research has been conducted to accurately distinguish patients with sepsis from those with non-infectious causes of disease. Technological innovations have positioned systems biology at the forefront of biomarker discovery. Analysis of the whole-blood leukocyte transcriptome enables the assessment of thousands of molecular signals beyond simply measuring several proteins in plasma, which for use as biomarkers is important since combinations of biomarkers likely provide more diagnostic accuracy than the measurement of single ones or a few. Evidence suggests that genome-wide transcriptional profiling of blood leukocytes can assist in differentiating between infection and non-infectious causes of severe disease. Of importance, RNA biomarkers have the potential advantage that they can be measured reliably in rapid quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)-based point of care tests. PAXgene blood RNA was isolated at intensive-care unit (ICU) admission and throughout ICU length-of-stay. Through the use of genome-wide microarrays we aimed to identify molecular features that enbale the adequate discrimination of infectious and non-infectious sources of critical illness. Moreover, biological pathway analysis was used to tease out the most relevant biological units in sepsis and septic shock.

2015-07-06 | E-GEOD-65682 | biostudies-arrayexpress

Secrets of the hospital underbelly: abundance of antimicrobial resistance genes in hospital wastewater reflects hospital antimicrobial use and inpatient length of stay

Project description:Secrets of the hospital underbelly: abundance of antimicrobial resistance genes in hospital wastewater reflects hospital antimicrobial use and inpatient length of stay

| PRJEB34410 | ENA

A Novel Model of Common TLR4- and Injury induced transcriptional themes in Human Leukocytes (supported by NIH grant GM34695)

Project description:Fifteen human volunteer subjects (18-40 years of age) and 5 Trauma patients were studied. One volunteer group (saline + LPS [n = 8]) received a 12 hour infusion a second volunteer group (cortisol + LPS [n = 7]) received a 12 hour infusion of cortisol (3 Âµg/kg/min). After 6 hours of saline or cortisol infusion, intravenous lipopolysaccharide (2 ng/kg) was administered to all subjects. Blood samples were collected at 0 hours, 6 hours and 24 hours relative to LPS administration at 0 hours. Blood samples were drawn from a grounp of Trauma patients shortly (day1-5) after admission and later in their ICU stay (day 5-7). Leukocytes were isolated from these blood samples, total RNA extracted, and microarray analyses performed using Affymetrix Focus GeneChipsÂ® on samples yeilding sufficent quantity and quality RNA for analysis. Blood samples were collected at 0hr, 6hr, and 24hr in relation to the LPS infusion. For both saline and cortisol treated subjects, infusion was started at (-6) hr and continued to (+6) hr.

2010-06-23 | E-GEOD-22278 | biostudies-arrayexpress

Unresolved Immune Dysfunction is Lethal in Both COVID-19 and non-COVID-19 Sepsis

Project description:In this prospective observational cohort study, we found transcriptional evidence that persistent immune dysfunction was associated with 28-day mortality in both COVID-19 and non-COVID-19 septic patients. COVID-19 patients had an early antiviral response but became indistinguishable on a gene expression level from non-COVID-19 sepsis patients a week later. Early treatment of COVID-19 and non-COVID-19 sepsis ICU patients should focus on pathogen control, but both patient groups also require novel immunomodulatory treatments, particularly later during ICU hospitalization, independent of admission diagnosis. Some T1 samples were uploaded in GSE185263 and were not re-uploaded in this series.

2023-03-24 | GSE222393 | GEO

Time series gene expression in critically ill patients: PREVAIL study

Project description:The PREVAIL study was a Phase II/III randomized controlled trial examining the use of lactoferrin to prevent nosocomial infections in critically ill patients undergoing mechanical ventilation. Gene expression data was generated from a consecutive subset of patients at the lead study site. We used the Affymetrix PrimeView array to generate expression data at various time points during the ICU stay.

2018-08-22 | GSE118657 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data