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Correlation analysis of intestinal flora and its metabolites with tumor nutritional status in patients with colorectal cancer

ABSTRACT: Interventions: Intestinal cancer with hyperlipidemia group + Intestinal cancer with normal blood lipid group:No Intervention Primary outcome(s): butyrate;Butyricicoccus pullicaecorum Study Design: Factorial

DISEASE(S): Colorectal Cancer

PROVIDER: 2683475 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Microbial-Derived Metabolites Regulate the Colonic Crypt Niche

Project description:In the mammalian intestine, crypts of LeiberkÃ¼hn house intestinal epithelial stem /progenitor cells at their base. We found that the presence of this structure was supported by the physiologic role of a prominent bacterial metabolite, butyrate. This bacterially-produced short chain fatty acid inhibited intestinal epithelial proliferation at physiologic concentrations. During homeostasis, butyrate did not suppress epithelial stem proliferation because it was metabolized by differentiated colonocytes. Provision of butyrate access to stem/progenitor cells either through mucosal injury or application to a crypt-less host led to inhibition of proliferation. The mechanism was dependent on HDAC inhibition in stem cells and the transcription factor Foxo3. Thus, the mammalian crypt unit structure provides energy for differentiated cells at a distance from the crypt base and this action prevents suppression of stem/progenitor proliferation. In total 4 samples were analyzed from 2 independent experiments. Two samples of colonic stem cells treated with 1mM Butyrate and two samples of colonic stem cells treated with 1mM NaCl (mock) as a control

2016-06-27 | E-GEOD-74601 | biostudies-arrayexpress

Microbial-Derived Metabolites Regulate the Colonic Crypt Niche

Project description:In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem /progenitor cells at their base. We found that the presence of this structure was supported by the physiologic role of a prominent bacterial metabolite, butyrate. This bacterially-produced short chain fatty acid inhibited intestinal epithelial proliferation at physiologic concentrations. During homeostasis, butyrate did not suppress epithelial stem proliferation because it was metabolized by differentiated colonocytes. Provision of butyrate access to stem/progenitor cells either through mucosal injury or application to a crypt-less host led to inhibition of proliferation. The mechanism was dependent on HDAC inhibition in stem cells and the transcription factor Foxo3. Thus, the mammalian crypt unit structure provides energy for differentiated cells at a distance from the crypt base and this action prevents suppression of stem/progenitor proliferation.

2016-06-27 | GSE74601 | GEO

Correlation between preoperative dyslipidemia and perioperative neurocognitive impairment in elderly patients with colorectal cancer

Project description:Interventions: Dyslipidemia group:Nil;Normal blood lipid group:Nil Primary outcome(s): Minimum Mental State Examination (MMSE) Study Design: Factorial

| 2760172 | ecrin-mdr-crc

intestinal flora

Project description:They were the microbe in intestinal flora of mice in different treatment group. metagenome

| PRJNA306395 | ENA

Gut microbiome metabolites alter genomic networks in PC12 cells relevant to autism spectrum diorders

Project description:Alterations in the composition of the gut microbiome have an emerging role in brain function and behaviour. We have porposed that short chain fatty acids (SCFA) including propionate and butyrate which are present in the diet and are fermantation products of many gastrointestinal bacteria are contributing environmental factors in autism spectrum disorders (ASD). Here we used the microarray technology to compare global changes in gene expression profiles following exposure of PC12 cells to structurally related SCFA propionate and butyrate each in two different concentrations. Large number of affected genes, common for both SCFA were identified, including genetic networks and GO processes implicated in ASD. PC12 cells were exposed to propionate or butyrate. RNA was isolated from each experimental group (n=6, pooled samples) and subjected to genome-wide expression profiling using Affymetrix microarrays to reveal dose- and SCFA-specific changes in gene expression and specific molecular pathways or processes affected as compared to vehicle treated controls.

2014-06-02 | E-GEOD-56516 | biostudies-arrayexpress

Correlation Between the Efficacy of Neoadjuvant Chemotherapy Combined With Immunotherapy of Operable Thoracic Esophageal Squamous Cell Carcinoma and the Metabolites of Intestinal Flora

Project description:This study collects stool, blood, and tumor tissue samples from patients with locally advanced esophageal cancer after receiving Sintilimab and chemotherapy to explore the efficacy and intestinal microbes of chemotherapy combined with neoadjuvant immunotherapy for locally advanced operable thoracic esophageal squamous cell carcinoma The main purpose is the relationship between its metabolites, and it will also explore the changes of intestinal flora diversity and metabolites before and after esophageal squamous cell carcinoma chemotherapy combined with immune neoadjuvant therapy

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Screening predictive targets for efficacy evaluation of chemotherapy and targeted drug therapy in advanced colorectal cancer from the view of gut flora and microbial metabolites

Project description:Interventions: The effective group:Targeted therapy;The less effective group:Targeted therapy Primary outcome(s): Flora;metabolites Study Design: Factorial

| 2683447 | ecrin-mdr-crc

Study on the function of intestinal flora in castration treatment of prostate cancer complicated with metabolic syndrome

Project description:Interventions: DM group and non-DM:Androgen Deprivation Therapy Primary outcome(s): blood glucose, glycated hemoglobin, insulin;intestinal flora;fecal metabolites Study Design: Factorial

| 2692103 | ecrin-mdr-crc

Effect of preventive terminal ileostomy on intestinal flora in patients with rectal cancer

Project description:Interventions: Rectal radical resection and one-stage anastomosis group:No;Radical rectal resection with one-stage anastomosis and terminal ileum double-lumen fistula group:No Primary outcome(s): Change of intestinal flora composition;Serum tumor marker Study Design: Factorial

| 2759146 | ecrin-mdr-crc

Gene expression profile of butyrate mediated prevention of coloractal cancer in a mouse model

Project description:To further elucidate the mechanism of butyrate mediated chemoprevention of colorectal cancer,we have employed whole genome microarray expression profiling as a discovery platform to identify genes that differentially expressed in mice from Butyrate group compared those from DMH group. The mice of DMH group were received normal diet (calcium concentration,1.24%) and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks; the mice of Butyrate group were received high calcium diet (calcium concentration,3%) with 1.5% Butyrate and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks. The mice were sarcrificed at 24 week. Nine normal colonic mucosa (3 from DMH group, 3 from Butyrate group mice with tumors, and 3 from Butyrate group mice without tumors) were used for the microarray analysis.

2011-12-31 | GSE25858 | GEO

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