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Changes in lung ultrasound and Optimization of recruitment maneuvers in laparoscopic colorectal cancer surgery

ABSTRACT: Interventions: 1:with no lung recruitment maneuver;2:lung recruitment maneuver every 30 minutes after intubation;3:lung recruitment maneuver every 60 minutes after intubation Primary outcome(s): Lung ultrasound Study Design: Parallel

DISEASE(S): Laparoscopic Colorectal Cancer Surgery

PROVIDER: 2684387 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Ultrasound evaluation of the incidence of atelectasis and lung recruitment in laparoscopic surgery in elderly patients

Project description:Interventions: Experimental group:Ultrasound-guided lung recruitment;Control group:no Primary outcome(s): Lung ultrasound Study Design: Parallel

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Application of lung ultrasound in laparoscopic colorectal cancer surgery

Project description:Interventions: carbohydrate group:alveolar recruitment manoeuvre;control group:with no alveolar recruitment manoeuvre Primary outcome(s): juxtapleural consolidation;the lung sliding sign;A lines;B lines;air-bronchograms Study Design: Randomized parallel controlled trial

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Gene Expression Changes in Therapeutic Ultrasound-Treated Human Chronic Wound Tissue

Project description:The purpose of this study was to evaluate gene expression differences in debrided human venous ulcer tissue from patients treated with low-frequency (20 kHz), low-intensity (100 mW/cm2) ultrasound compared to a sham treatment in an effort to better understand the potential biological mechanisms.

2023-02-01 | GSE222503 | GEO

Transcription profiling of human leukemia U937 cells treated with the combination of Sonazoid and ultrasound

Project description:Echo-contrast agents enhance the echogenicity of ultrasound and have been clinically used for diagonosis in current medical fields. Here, the combined effects of Sonazoid, an echo-contrast agent, and ultrasound on the gene expression in human lymphoma U937 cells were investigated using an Affymetrix GeneChip system. The cells were treated with Sonazoid (0.05%; Sonazoid only), ultrasound (0.3 W/cm2 for 1 min; ultrasound only) and the combination of Sonazoid and ultrasound (0.05% Sonazoid plus ultrasound 0.3 W/cm2 for 1 min; Sonazoid + Ultrasound) and followed by incubation for 3 h at 37Â°C. The percentage of DNA fragmentation 6 h after treatment was 5.8 Â± 1.0 (mean Â± SD, n = 3), 6.0 Â± 0.4, 13.5 Â± 1.0, and 18.3 Â± 2.3 in cells treated with control, Sonazoid only, ultrasound only and Sonazoid + Ultrasound, respectively. Of approximately 47,000 probe sets analyzed, probe sets that were differentially expressed by a factor 2.0 or greater were 40, 184 and 144 in cells treated with Sonazoid only, ultrasound only and Sonazoid + Ultrasound, respectively. Experiment Overall Design: U937 cells, a human lymphoma cell line, were treated with Sonazoid (0.05%), ultrasound (0.3 W/cm2 for 1 min) and the combination of Sonazoid and ultrasound (0.05% Sonazoid plus ultrasound 0.3 W/cm2 for 1 min) and followed by incubation for 3 h at 37Â°C. Non-treated cells were served as control. Total RNA samples were prepared from the cells. Gene expression was analyzed by an Affymetrix GeneChipÂ® system with a Human Genome U133-plus 2.0 array for analysis of over 47,000 transcripts. Sample preparation for array hybridization was carried out as described in the manufacturerâ??s instructions.

2009-05-27 | E-GEOD-16118 | biostudies-arrayexpress

Identification of genes responsive to the combination of Sonazoid and ultrasound in human leukemia U937 cells

2009-05-16 | GSE16118 | GEO

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound

Project description:Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise, and safe induction of a torpor-like hypothermic and hypometabolic state in rodents by remote transcranial ultrasound stimulation at the hypothalamus preoptic area (POA). We achieve a long-lasting (> 24 hours) torpor-like state in mice via closed-loop feedback control of ultrasound stimulation with automated detection of body temperature. Ultrasound-induced hypothermia and hypometabolism (UIH) is triggered by activation of POA neurons, involves the dorsomedial hypothalamus as a downstream brain region and subsequent inhibition of thermogenic brown adipose tissue. Single-nucleus RNA-sequencing of POA neurons reveals TRPM2 as an ultrasound-sensitive ion channel, the knockdown of which suppresses UIH. We also demonstrate that UIH is feasible in a non-torpid animal, the rat. Our findings establish UIH as a promising technology for the noninvasive and safe induction of a torpor-like state. To investigate the mechanism of ultrasound-induced neuronal activation, we applied ultrasound stimulation in hypothalamic preoptic area region and performed single-nuclei RNA sequencing in the ultrasound stimulated neurons (US+) and neurons without ultrasound stimulation (US-). In our sn-RNAseq analysis, we examined the association between the expression of neuronal activation markers (or IEGs) and ion channels, as well as neuron types.

2023-03-29 | GSE228180 | GEO

Gene expression profie at single cell level of lung cells in healthy rats and rats with pulmonary hypertension treated with sham-stimulation or ultrasound

Project description:Focused ultrasound of the spleen is an emerging therapeutic modality and recent reports have shown efficacy in reducing inflammation. We used scRNA seq to identify the gene expression changes in lungs of healthy animals, animals with pulmonary hypertension treated with focused ultrasound of the spleen or sham stimulation.

2023-12-01 | GSE247625 | GEO

Dynamic Changes in Extracellular Vesicle-Associated miRNAs Elicited by Abdominal Ultrasound in Peripheral Blood of Inflammatory Bowel Disease Patients

Project description:Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect the cellular and functional state of their site of site of origin. As ultrasound waves may lead to an increased release of EVs, we hypothesized that application of ultrasound waves on inflamed intestinal tissue in IBD may amplify the release of tissue-specific EVs, which in turn can be detected in the peripheral blood.

2024-04-23 | GSE237994 | GEO

Halothane/Isoflurane Repetitive Exposures

Project description:Rats were exposed to 90 minutes of 0.8% halothane or 1.0% isoflurane twice a day for a total of 5 or 10 exposures. Animals did not require intubation. All exposures and hybridizations were performed at the Univ. of Pennsylvania. Keywords = anesthetics Keywords: other

2003-10-20 | GSE752 | GEO

Changes in DNaseI hypersensitivity upon ultradian (pulsed) hormone stimulation [Dnase-seq]

Project description:We report changes in DNaseI accessibility genome-wide upon treatment with corticosterone (Cort) for 20 minutes, treatment with Cort for 20 minutes followed by hormone withdrawal for 40 minutes, 60 minutes continuous stimulation with Cort, as well as Mock treatments for the aforementioned conditions.

2015-02-12 | GSE61235 | GEO

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