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Related factors of synchronous peritoneal metastasis in colorectal cancer: a retrospective study based on medical records

ABSTRACT: Interventions: Peritoneal metastasis group :N/A;Non- Peritoneal metastasis group:N/A Primary outcome(s): Age;blood CEA level;tumor location;blood CA125;blood CA199;pathological type;differentiation degree;Gender Study Design: Factorial

DISEASE(S): Colorectal Cancer,Peritoneal Metastasis

PROVIDER: 2686261 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Clinical research and the mechanism of Cinobufotalin combination chemotherapy prevent the relapse and metastasis of colorectal cancer

Project description:Interventions: Trial group :Cinobufotalin combination chemotherapy ;Control:Chemotherapy Primary outcome(s): routine blood test;Urine routine test;Fecal routine test;Fecal occult blood;Liver and kidney function;Immune functionCD3?CD4;Tumor markers CA199, CEA, CA50, CA125;TCM Syndrome Rating Scale;Piper Fatigue Scale Study Design: Randomized parallel controlled trial

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electronic Medical Records & Genomics (eMERGE)

Project description:electronic Medical Records & Genomics (eMERGE)

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Gastric carcinoma patients and healthy subjects

Project description:Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease (>50%). Currently, there are limited clinical approaches for predicting and treatment of peritoneal metastasis, resulting in a 6- month average survival time. By comprehensive genome analysis will uncover the pathogenesis of peritoneal metastasis. Here we describe a comprehensive whole-genome and transcriptome sequencing analysis of one advanced gastric cancer case, including non-cancerous mucosa, primary cancer and matched peritoneal metastatic cancer. The peripheral blood is used as normal control.

2019-06-12 | GSE64916 | GEO

Early adaptation of colorectal cancer cells to the peritoneal cavity depends on activation of ‘stemness’ programs and local inflammation.

Project description:Purpose: At diagnosis, colorectal cancer presents with synchronous peritoneal metastasis in up to 10% of patients. The peritoneum is poorly characterized with respect to its super-specialised microenvironment. Our aim was to describe the differences between peritoneal metastases and their matched primary tumours excised simultaneously at the time of surgery. Also, we tested the hypothesis of these differences being present in primary colorectal tumours and having prognostic capacity. Experimental design: We report a comprehensive analysis of thirty samples from peritoneal metastasis with their matched colorectal cancer primaries obtained during cytoreductive surgery. We tested and validated the prognostic value of our findings in a pooled series of 660 colorectal cancer primary samples with overall survival (OS) information and 743 samples with disease free survival (DFS) information from publicly available databases. Results: We identified 20 genes dysregulated in peritoneal metastasis that promote an early increasing role of ‘stemness’ in conjunction with tumour favorable inflammatory changes. When adjusted for age, gender and stage, the 20-gene peritoneal signature proved to have prognostic value for both OS (adjusted-hazard ratio (HR) for the high-risk group (vs low-risk) 2.32 (95% confidence interval (CI) 1.69-3.19; p-value < 0.0001)) and for DFS (adjusted-HR 2.08 (95%CI 1.50-2.91; p-value < 0.0001)). Conclusions: Our findings indicated that the activation of “stemness” pathways and adaptation to the peritoneal specific environment are key to early stages of peritoneal carcinomatosis. The in-silico analysis suggested that this 20-gene peritoneal signature may hold prognostic information with potential for development of new precision medicine strategies in this setting.

2020-11-13 | GSE161097 | GEO

A comprehensive, retrospective study of gastrointestinal diseases and associated factors using medical records at Toyoshima Endoscopy Clinic

Project description:Primary outcome(s): The relationship between gastrointestinal diseases, including esophageal, gastric, and colorectal cancer, and corresponding risk factors (age, gender, past medical history, family medical history, disease, findings, treatment)

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Apoptosis enhancing drugs overcome innate platinum resistance in CA125 negative tumor initiating populations of high grade serous ovarian cancer

Project description:High grade serous ovarian cancers (HGSC) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSCs contain a CA125 negative population enriched for carboplatin resistant cancer initiating cells. Transcriptome analysis reveals up-regulation of homologous recombination DNA repair and anti-apoptotic signals in this population. While treatment with carboplatin enriches for CA125 negative cells, co-treatment with carboplatin and birinapant eliminates these cells in HGSCs expressing high levels of the inhibitor of apoptosis protein cIAP in the CA125 negative population. Birinapant sensitizes CA125 negative cells to carboplatin by mediating degradation of cIAP causing cleavage of caspase-8 and restoration of apoptosis. This co-therapy significantly improved disease free survival in vivo compared to either therapy alone in tumor-bearing mice. These findings suggest that therapeutic strategies that target CA125 negative cells may be useful in the treatment of HGSC. mRNA profiles of CA125 positive and negative populations, generated by next generation sequencing of populations FACS isolated from 10 independent dissociated primary human high grade serous ovarian cancers, were compared.

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Excess shed mesothelin disrupts pancreatic cancer cell clustering to impair peritoneal colonization

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2024-12-19 | GSE260587 | GEO

Apoptosis enhancing drugs overcome innate platinum resistance in CA125 negative tumor initiating populations of high grade serous ovarian cancer

2015-08-01 | GSE70072 | GEO

GCP study

Project description:Genome sequencing data of gastric cancer with peritoneal metastasis.

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Gender- and Age-Based Characterization and Comparison of the Murine Primary Peritoneal Mesothelial Cell Proteome

Project description:Raw and processed data in support of manuscript "Gender- and Age-Based Characterization and Comparison of the Murine Primary Peritoneal Mesothelial Cell Proteome" Zhikun Wang1,2, Yueying Liu1,2, Reihaneh Safavisohi1,2, Marwa Asem1,2, Daniel Hu1, Mary Sharon Stack1,2,3, Matthew M. Champion1,3 1Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame IN 46556; 2Harper Cancer Research Institute, University of Notre Dame, South Bend IN 46617

2023-06-09 | MSV000092134 | MassIVE

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