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Effects of inhalation and intravenous anesthetics on perioperative CD8+T cell function in patients with colorectal cancer

ABSTRACT: Interventions: Inhalation anesthesia group:Inhalation anesthesia;Intravenous anesthesia group:Intravenous anesthesia Primary outcome(s): Programmed cell death protein 1;CD28;CD8 Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2699341 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effects of inhalation and intravenous anesthetics on perioperative CD8+T cell function in patients with colorectal cancer

Project description:Interventions: Inhalation anesthesia group:Intravenous anesthesia;Intravenous anesthesia group:Intravenous anesthesia Primary outcome(s): Programmed cell death protein 1;CD28;CD8 Study Design: Parallel

| 2699232 | ecrin-mdr-crc

Effects of intravenous anesthesia and inhalation anesthesia on perioperative intestinal immune function and systemic inflammatory response in patients with colon cancer

Project description:Interventions: Group 1 :Morning surgery: intravenous anesthesia;Group 2:Morning surgery: inhalational anesthesia;Group 3:Afternoon surgery: intravenous anesthesia;Group 4:Afternoon surgery: inhalational anesthesia Primary outcome(s): CD+4T cells;Interleukin-22 Study Design: Parallel

| 79381 | ecrin-mdr-crc

Effects of sevoflurane inhalation anesthesia on proliferation and apoptosis of colon cancer cells in vitro: a randomized controlled trial.

Project description:Interventions: Sevo:Sevoflurane inhalation anesthesia was performed during the operation;Pro:propofol intravenous anesthesia was performed during the operation;Sevo+Pro:sevoflurane—propofol combined anesthesia during the operation Primary outcome(s): Postoperative mortality Study Design: Parallel

| 2699849 | ecrin-mdr-crc

Effects of dexmedetomidine combined with epidural anesthesia on intestinal function and postoperative outcomes of patients undergoing laparoscopic colorectal cancer surgery

Project description:Interventions: Control group (CON group):Intravenous and inhalation combined anesthesia, equal amount of normal saline; Sufentanil PCIA.;Dexmedetomidine group (DEX group):Dexmedetomidine group (DEX group): intravenous anesthesia was assisted by intravenous of DEX with the loading dose of 0.5~1.0 microgram/kg completed within 10 minutes and maintenance infusion of 0.5~1.0 microgram /kg/h until the end of the operation. Sufentanil + DEX to implement PCIA.; Epidural group (EP group):Intravenous Inhalation Combined with epidural anesthesia, ropivacaine + sufentanil PCEA;DEX + EP group:Intravenous anesthesia assisted by intravenous DEX combined with epidural anesthesia, ropivacaine + DEX PCEA. Primary outcome(s): Peristalsis time after operation;Oral feeding time after operation Study Design: Parallel

| 47743 | ecrin-mdr-crc

Effect of perioperative intravenous lidocaine on postoperative fatigue syndrome in patients with gastrointestinal tumor

Project description:Interventions: Group L:Intravenous lidocaine infusion before induction of anesthesia and intraoperatively;Group C:Intravenous saline infusion before induction of anesthesia and intraoperatively Primary outcome(s): Christensen’s Visual Analogue Scales Study Design: Parallel

| 106425 | ecrin-mdr-crc

Intravenous Nanoparticle Vaccination Generates Stem-Like TCF1+ Neoantigen-Specific CD8 T Cells

Project description:Intravenous Nanoparticle Vaccination Generates Stem-Like TCF1+ Neoantigen-Specific CD8 T Cells

| PRJNA664405 | ENA

Smoke Inhalation and NIST SRM Lipidomics

Project description:LC-IMS-CID-MS lipidomics of BALF and plasma from severe smoke inhalation and NIST SRM 1950.

2021-11-12 | MSV000088372 | MassIVE

28d Rat Inhalation Study

Project description:We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk tobacco product (pMRTP) at the same nicotine concentration as the high 3R4F group, i.e., 23 ug nicotine/l. Following CS inhalation, rats mainly develop irritative stress-related adaptive changes in the upper airways and signs of inflammation in the lung, a common condition preceding smoking-related lung diseases such as COPD and lung cancer. In the current study, the feasibility of investigating disease-relevant molecular perturbations at the sites of histopathological changes towards a Systems systems Biologybiology-based risk assessment was tested, using state-of-the-art technologies for sample preparation, analysis, and interpretation of gene expression arrays in combination with the classical toxicology end points.

2014-05-30 | E-MTAB-1842 | biostudies-arrayexpress

The multi-center clinical study of perioperative electroacupuncture on intestinal barrier to enhance recovery after colorectal cancer surgery

Project description:Interventions: Group 2:Systemic intravenous anesthesia + perioperative electropuncture;Group 1:Systemic intravenous anesthesia Primary outcome(s): anal exhaust time;D-lactose;diamine-oxidase;endotoxin Study Design: Randomized parallel controlled trial

| 2679319 | ecrin-mdr-crc

Blood transcriptome following intravenous BCG vaccination in rhesus macaques

Project description:To determine the blood transcriptional response to intravenous (IV) BCG vaccination in rhesus macaques and identify correlates of vaccine-mediated protection against Mycobacterium tuberculosis (Mtb) challenge.

2023-06-19 | GSE218270 | GEO

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