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XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation

ABSTRACT: This is a first-in-human multi-center study which will be conducted in advanced malignant solid tumors patients. The solid tumor type is limited to melanoma, colorectal, non-small-cell lung, and thyroid cancer with positive BRAF V600 mutation. This study is divided into three stages: Phase Ia: a dose-escalation phase of XP-102; Phase Ib: a dose-escalation and sample size expansion phase of XP-102 plus trametinib; Phase IIa: an expansion phase of XP-102 plus trametinib.

DISEASE(S): Thyroid Cancer,Melanoma,Colorectal Cancer,Carcinoma, Non-small-cell Lung,Braf V600 Mutation,Cancer,Nonsmall Cell Lung Cancer

PROVIDER: 2708993 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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