Browse
Submit Data
Databases
API
Help

Dataset Information

44 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The relationship between the expression of ALDHs and the clinicopathological parameters and prognosis of patients with colorectal cancer

ABSTRACT: Interventions: Case series:None Primary outcome(s): Protein expression of each isoform of acetaldehyde dehydrogenase Study Design: Sequential

DISEASE(S): Colorectal Cancer

PROVIDER: 2716115 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Study on the relationship between changes of intestinal fungi and primary liver cancer

Project description:Interventions: Case series:None Primary outcome(s): intestinal fungi Study Design: Sequential

| 35158 | ecrin-mdr-crc

the expression and correlation analysis between SPT6/SND1/hTERT and colorectal carcinoma

Project description:Interventions: Case series:none Primary outcome(s): SPT6/SND1/hTERT Study Design: Sequential

| 2689343 | ecrin-mdr-crc

Medical records based study for correlation between preoperative anemia and postoperative complications and prognosis in patients with colorectal cancer

Project description:Interventions: case series:None Primary outcome(s): Postoperative complications Study Design: Sequential

| 2725782 | ecrin-mdr-crc

Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer.

Project description:BackgroundAimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori.Methods157 patients were enrolled, all patients had a record of clinicopathological parameters. Specimens including the tumor and non-neoplastic were detected for H.Pylori by Real-Time PCR and analyzed clinical data retrospectively. Variables independently affecting prognosis were investigated by means of multivariate analysis using the Cox proportional hazards model.ResultsH.Pylori infection was greater in non-neoplastic tissue than the tumor tissue (p < 0.05), H.Pylori infection and its copies were related to the tumor site and N staging (p < 0.05). Overall survival (OS) in all 157 patients has no correlation with the H.Pylori infection status (p = 0.715). As to the patients who underwent a curative surgery, relapse-free survival (RFS) has no correlation with the H.Pylori infection status (p = 0.639). Among the H.Pylori positive patients, OS and RFS of those with higher copies were longer than in patients with low copies, but there was no significant statistical difference.ConclusionsH.Pylori infection status and its copies were related to N staging. The OS and RFS in patients with positive H.Pylori status has no significant difference from the patients with negative H.Pylori status.

| S-EPMC2914705 | biostudies-literature

KNBP based MRD monitoring of resectable stage II-IV colorectal cancer and its correlation with prognosis

Project description:Interventions: Case series:None Primary outcome(s): ctDNA Study Design: Sequential

| 81452 | ecrin-mdr-crc

Comparison of MSI detection between next-generation sequencing and PCR in different tumors

Project description:Interventions: Case series:None Primary outcome(s): Concordance;negative predictive value Study Design: Sequential

| 41336 | ecrin-mdr-crc

Exploring the relationship between colorectal cancer and intestinal flora in Chengdu based on high-throughput sequencing

Project description:Interventions: Colorectal cancer group:None;Healthy control group:None Primary outcome(s): Faecal flora Study Design: Sequential

| 85543 | ecrin-mdr-crc

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response.

Project description:BackgroundCyclin-Dependent Kinases (CDKs) are established anti-cancer drug targets and a new generation of CDK inhibitors are providing clinical benefits to a sub-set of breast cancer patients. We have recently shown that human CDK18 promotes efficient cellular responses to replication stress. In the current study, we have investigated the clinicopathological and functional significance of CDK18 expression levels in breast cancers.ResultsHigh CDK18 protein expression was associated with a triple negative and basal-like phenotype (p = 0.021 and 0.027 respectively) as well as improved patient survival, which was particularly significant in ER negative breast cancers (n = 594, Log Rank 6.724, p = 0.01) and those treated with chemotherapy (n = 270, Log Rank 4.575, p = 0.03). In agreement with these clinical findings, breast cancer cells genetically manipulated using a dCRISPR approach to express high levels of endogenous CDK18 exhibited an increased sensitivity to replication stress-inducing chemotherapeutic agents, as a consequence to defective replication stress signalling at the molecular level.ConclusionsThese data reveal that CDK18 protein levels may predict breast cancer disease progression and response to chemotherapy, and provide further rationale for potential targeting of CDK18 as part of novel anti-cancer strategies for human cancers.Materials and methodsCDK18 protein expression was evaluated in 1650 breast cancers and correlated to clinicopathological parameters and survival outcomes. Similar analyses were carried out for genetic and transcriptomic changes in CDK18 within several publically available breast cancer cohorts. Additionally, we used a deactivated CRISPR/Cas9 approach (dCRISPR) to elucidate the molecular consequences of heightened endogenous CDK18 expression within breast cancer cells.

| S-EPMC6047673 | biostudies-literature

The relationship between urotensin II and its receptor and the clinicopathological parameters of breast cancer.

Project description:BackgroundUrotensin II is a vasoactive polypeptide. It is known that some vasoactive polypeptides are produced and secreted by tumor cells, and act as a paracrine growth stimulant. The aim of this study was to examine the relationship between urotensin II and its receptor's messenger RNA expression in breast cancer.Material/methodsFifty-nine women with breast cancer were included in this study. The median age was 48 years. The relationships between urotensin II and urotensin II receptor mRNA expressions, which were derived from fresh breast cancer tissues and adjacent normal breast tissues, and clinical and pathological parameters, were assessed.ResultsWe found expressions of urotensin II mRNA and its receptor in 55 of 59 breast cancer tissues and in 55 of 59 normal breast tissues. We found a positive significant correlation between urotensin II and its receptor (p=0.001, r=0.632), and found a negative, but insignificant, correlation between urotensin II and age (p=0.038, r=-0.281). Urotensin II levels were higher in the premenopausal group compared to the postmenopausal group (p<0.05). The mean urotensin II receptor expression was higher in the premenopausal group (p<0.05) compared to the postmenopausal group, and its expression was also higher in the group without extra-nodal invasion compared to that of the group with extra-nodal invasion (p=0.001). Urotensin II levels were higher in the group without lymphatic invasion compared to the group with lymphatic invasion (p=0.048).ConclusionsThis study is the first in the English medical literature to determine the urotensin II and its receptor mRNA expressions in breast cancer tissues. Consequently, urotensin II seems be associated with menopausal status, and extra-nodal and lymphatic invasion.

| S-EPMC4138065 | biostudies-literature

Relationship between LINC00341 expression and cancer prognosis.

Project description:LINC00341 is a novel long intergenic non-protein coding RNA with unknown functions. In our report, we investigated LINC00341 expression and its prognostic value in cancer patients. DNA over-methylation triggered low expression of LINC00341 and that was associated with poor prognosis in cancers. A meta-analysis further confirmed that high expression of LINC00341 was associated with a better prognosis in cancer patients. Both gene set enrichment analysis and meta-analysis showed that LINC00341 inhibited cancer metastasis. Finally, a large-scale multicentre analysis supported a prognostic value of LINC00341 in cancers.

| S-EPMC5362486 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data