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The effect of goal-directed fluid therapy combined with lung protective ventilation strategy on the cardiopulmonary function of patients undergoing laparoscopic radical resection of colorectal cancer

ABSTRACT: Interventions: TG group:GDFT combined with traditional ventilation;PG group:GDFT and LPS Primary outcome(s): Respiratory dynamics index Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2716233 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effects of goal-directed fluid therapy on postoperative outcomes in patients undergoing laparoscopic colorectal surgery in different levels of systemic vascular resistance after general anesthesia

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Effects of Goal-directed Fluid Therapy guided by SVV on intestinal barrier function in patients undergoing colon cancer surgery

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Lung ventilation

Project description:This project focuses both on the separate and combined effects of large tidal volume ventilation and hyperoxia on gene expression in the lungs of anesthetized rats. Rats were either mechanically or spontaneously ventilated at either 21 or 100% oxygen and expression levels were evaluated on RG_U34 GeneChips. Keywords: other

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Mechanisms of variable ventilation in experimental lung injury

Project description:In the present study we seek to identify changes in lung gene expression under mechanical ventilation in uninjured as well as acutely and chronically injured lungs. A standard volume-controlled lung-protective ventilatory protocol is compared to a concept of mechanical ventilation using variable tidal volumes.

2017-02-17 | GSE78008 | GEO

The PROtective Ventilation Using Open Lung Approach Or Not Trial

Project description:Postoperative Pulmonary Complications (PPC) are very common. It severely affects postoperative recovery, particularly in the abdominal surgery. Patients with laparoscopic resection of colorectal cancer generally have a higher age and decreased lung function reserve. At the same time, they prone to developing atelectasis due to the effects of pneumoperitoneum pressure. Therefore, they are a high-risk group of respiratory insufficiency and PPC. Mechanical ventilation with a low tidal volume is a routine in clinic nowadays. However, this conventional strategy will also result in atelectasis formation. Therefore, it may deteriorate the vulnerable lung function of patients undergoing laparoscopic resection of colorectal cancer. Patients with Acute Lung Injury or Acute Respiratory Distress Syndrome (ALI/ARDS) could benefit from the "open lung approach", including the use of positive end-expiratory pressure (PEEP) and recruitment maneuvers (RMs). Whether a lung protective mechanical ventilation strategy with medium levels of PEEP and repeated RMs, the "open lung approach", protects against respiratory insufficiency and PPC during laparoscopic resection of colorectal cancer is uncertain. The present study aims at comparing the effects of "open lung approach" mechanical ventilation strategy and conventional mechanical ventilation strategy in PPC, extra-pulmonary complications, length of hospital stay, biomarkers of lung injury and changes of respiratory function in patients undergoing general anesthesia for laparoscopic resection of colorectal cancer.

| 2244915 | ecrin-mdr-crc

The lung protective effect of driving pressure-guided pulmonary protective ventilation combined deep neuromuscular block in patients undergoing laparoscopic surgery for colorectal cancer

Project description:Intervention group:driving pressure-guided pulmonary protective ventilation combined deep neuromuscular block;Control group:normal pulmonary ventilation combined normal neuromuscular block Primary outcome(s): Postoperative pulmonary complications;Muscle relaxation monitoring Study Design: Parallel

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Expression data from intact and ventilation-preconditioned murine lungs

Project description:To study the effects of previous exposure to mechanical ventilation may modify the development of Ventilator-induced lung injury, preconditioning was induced by low-pressure ventilation for 90 minutes. After 1 week, intact (sham) and preconditioned mice were sacrificed, the lungs extracted and gene expression measured in order to identify differences responsible for the observed tolerance to ventilator-induced lung injury observed in preconditioned animals.

2015-08-21 | GSE65783 | GEO

Evaluation of pulmonary complications during laparoscopic surgery in patients with protective mechanical ventilation combined deep neuromuscular block

Project description:Interventions: Group 1:Lung-protective ventilation combined with deep neuromuscular blockade and low pneumoperitoneum pressure;Group 2:Conventional pulmonary ventilation combined with moderate NMB (neuromuscular blockade) and conventional pneumoperitoneum pressure Primary outcome(s): Postoperative Pulmonary Complications Study Design: Parallel

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Effect of perioperative goal-directed fluid therapy on postoperative complications after thoracic surgery with one-lung ventilation: a systematic review and meta-analysis.

Project description:BackgroundAn understanding of the impact of goal-directed fluid therapy (GDFT) on the outcomes of patients undergoing one-lung ventilation (OLV) for thoracic surgery remains incomplete and controversial. This meta-analysis aimed to assess the effect of GDFT compared to other fluid therapy strategies on the incidence of postoperative complications in patients with OLV.MethodsThe Embase, Cochrane Library, Web of Science, and MEDLINE via PubMed databases were searched from their inception to November 30, 2022. Forest plots were constructed to present the results of the meta-analysis. The quality of the included studies was evaluated using the Cochrane Collaboration tool and Risk Of Bias In Non-Randomized Study of Interventions (ROBINS-I). The primary outcome was the incidence of postoperative complications. Secondary outcomes were the length of hospital stay, PaO2/FiO2 ratio, total fluid infusion, inflammatory factors (TNF-α, IL-6), and postoperative bowel function recovery time.ResultsA total of 1318 patients from 11 studies were included in this review. The GDFT group had a lower incidence of postoperative complications [odds ratio (OR), 0.47; 95% confidence interval (95% CI), 0.29-0.75; P = 0.002; I 2, 67%], postoperative pulmonary complications (OR 0.48, 95% CI 0.27-0.83; P = 0.009), and postoperative anastomotic leakage (OR 0.51, 95% CI 0.27-0.97; P = 0.04). The GDFT strategy reduces total fluid infusion.ConclusionsGDFT is associated with lower postoperative complications and better survival outcomes after thoracic surgery for OLV.

| S-EPMC10506328 | biostudies-literature

Evaluation of pulmonary complications during laparoscopic surgery in patients with protective mechanical ventilation combined deep neuromuscular block

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