Study on the safety of modified MCT ketogenic diet and standard therapy combination therapy for colorectal cancer patients

ABSTRACT: Interventions: Nutrition counseling We provide outpatient nutritional guidance once a month for 30 minutes. It can be calculated once a month as an outpatient nutrition dietary guidance fee. The modified MCT ketogenic diet is 2-3 meals a day, prepared under the supervision of a registered dietitian, and you can cook your own food according to the following rules, or obtain low-carbohydrate foods at the supermarket or the Internet. .. Meal purchase funds will be borne by the patient. Cooking recipes will be distributed at the start of clinical research. 7 rules of dietary intake 1. The target energy intake is 35-40 kcal per body weight. 2. Eat 1.6-2.0 g of protein-rich foods (meat, fish, eggs, soy products) per body weight. 3. Take at least 4g of EPA daily. 4. Limit the amount of sugar to 25 g or less per day (when the body weight is 50 kg). 5. Ingest 60 to 100 g of medium-chain fatty acids per day in terms of MCT oil. 6. The weight of the meal is morning: noon: evening = 4: 10: 6, and the weight is adjusted so that the person feels hungry before going to bed. 7. The target ketone ratio is 1.4 to 1.6: 1. Estimated implementation period and meal contents (see A and B below) 1. First 3 months: Super ketogenic. 2. From 3 months to 1 year: Continue to eat ketogenic diet, mainly super ketogenic. 3. After the above research period is exceeded, we will instruct them to continue ketogenic and semi-ketogenic Level of carbohydrate restriction 1. Semi-ketogenic Ketone ratio Lipid: Sugar + Protein = 1: 1 Sugar intake 80 g / day or less Lipid intake: flaxseed oil 30 g / day, MCT oil 80 mg / day (total fat 110 g) 2. Ketogenic Ketone ratio Lipid: Sugar + Protein = 1.4: 1 Sugar intake 40 g / day or less Lipid intake: flaxseed oil 30 g / day, MCT oil 80 mg / day (total fat 110 Primary outcome(s): Safety Presence or absence of diarrhea or allergic symptoms b. Dehydration, symptomatological hypoglycemia, excessive ketosis, gastrointestinal symptoms Nutritional status (body weight, body composition analysis using In Body (BIA), serum albumin, serum cholinesterase, serum transthyretin, CRP), QOL score (EORTCQLQ-CR38 Japanese version, POMS2 Japanese version) Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2723656 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR