Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Efficacy and Safety of Multi Loop Traction Device-assisted Colorectal Endoscopic Submucosal Dissection: A Multicenter, Randomized Clinical Trial

ABSTRACT: Interventions: 1) MLTD-ESD group Colorectal endoscopic submucosal dissection (ESD) is performed using the Multi Loop Traction Device (MLTD). The number of MLTD used in a single session is not limited. The conversion of the allocated therapeutic method is permitted. If the MLTD is ineffective for more than 10 minutes, the MLTD can be removed. 2) Conventional ESD group ESD is completed using a standard therapeutic strategy that does not involve the use of traction devices. The conversion of the allocated therapeutic method is permitted. The MLTD can be used if the endoscopist determines that the traction device has been required for more than 10 minutes. Primary outcome(s): Dissection speed (area resected [mm^2]/duration in minutes) Study Design: Parallel Randomized

DISEASE(S): Colorectal Neoplasm

PROVIDER: 2724553 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Gonadal DNA methylomes of half-smooth tongue sole Cynoglossus semilaevis

Project description:Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa, and in some species co-occurs with genetic sex determination (GSD) mechanisms. Although epigenetic regulation in response to environmental effects has long been proposed to be associated with ESD, a systemic analysis on epigenetic regulation of ESD is still lacking. Using half-smooth tongue sole (Cynoglossus semilaevis) as a model – a marine fish which has both ZW chromosomal GSD and temperature-dependent ESD – we investigated the role of DNA methylation in transition from GSD to ESD by comparing gonadal DNA methylomes of parental females, parental pseudo-males, F1 females, F1 pseudo-males and normal males. To assess the gonadal DNA methylome patterns across different sexual types of tongue sole, we carried out BS-seq on bisulfite converted DNA extracted from adult gonads of parental females, parental pseudo-males, and F1 pseudo-males and females from a cross between a parental pseudo-male and a normal female. We also sampled normal male individuals as a control for the normal male DNA methylation pattern. For each of the five samples, two biological replicates were utilized, with each replicate being pooled by five fish. The phenotype and genotype of each selected fish was identified by the histological analysis and PCR validation using the W chromosome specific marker. DNA were isolated from five pooled gonads of the same replicate, then 5 ?g DNA was used to do the bisulfite conversion and BS-seq. The bisulfite conversion of sample DNA was carried out using a modified NH4HSO3-based protocol (Hayatsu et al. 2006). The paired-end library construction and sequencing were carried out using Illumina HiSeq 2000, according to the manufacturer’s instructions (Illumina). We also mixed 25 ng cl857 Sam7 Lambda DNA in each sample to use as conversion quality control for each library.

2014-01-23 | E-GEOD-41129 | biostudies-arrayexpress

Development and evaluation the safety of traction clip for colorectal endoscopic submucosal dissection.

Project description:Interventions: We study durablity and keeping quality of traction clip for colorectal ESD. Primary outcome(s): From May 1st, 2011 to March 31, 2013 Target cases are 50. Calcurate the interval from the date maked traction clip to colorectal ESD. Evaluate the safty and durabillty of traction clip for colorectal ESD. Study Design: Single arm Non-randomized

| 2622836 | ecrin-mdr-crc

Gonadal DNA methylomes of half-smooth tongue sole Cynoglossus semilaevis

2014-01-23 | GSE41129 | GEO

Feasibility study investigating the efficacy and safety of hybeid endoscopic submucosal dissection

Project description:Interventions: Patients with 20-30mm colorectal adenoma/intramucosal cancer were considered eligible. Hybrid ESD was performed using newly-developed device which enable scircumferential incision and submucosal dissection. Primary outcome(s): Complication rate assessed after endoscopic treatment Study Design: Single arm Non-randomized

| 2637804 | ecrin-mdr-crc

Application value of orthodontic rubber band traction technology in the cultivation of trainee of colorectal ESD

Project description:Interventions: Colorectal beginner ESD using the ORB group, colorectal beginner traditional ESD, expert group traditional ESD group:The orthodontic band was used for traction Primary outcome(s): Operating time Study Design: Parallel

| 41462 | ecrin-mdr-crc

Efficacy of traction assisted endoscopic submucosal dissection using clip and line for colorectal neoplasms: a randomized controlled trial

Project description:Interventions: Conventional ESD group Traction assisted ESD group Primary outcome(s): ESD procedure time which is measured from the start of the submucosal injection until removal of the lesion Study Design: Parallel Randomized

| 2633910 | ecrin-mdr-crc

A randomized controlled trial about the efficacy of colorectal ESD using a scissors-type knife with traction device for early colorectal neoplasms

Project description:Interventions: Group A: C (Conventional)-ESD Group B: T (Traction)-ESD Primary outcome(s): the resected specimen area to the procedure time Study Design: Parallel Randomized

| 2655319 | ecrin-mdr-crc

A study to evaluate the usefulness of traction-assisted endoscopic submucosal dissection using a newly developed all-in-one device used to resect colorectal polyps: a Multicenter Randomized Controlled Trial

Project description:Interventions: Procedure/Surgery : 1) onestep knife conventional ESD (control) ? Insert the colonoscope with the transparent cap attached. ? After puncturing the submucosal layer immediately around the lesion with a puncture needle for submucosal solution injection, inject the saline-based submucosal solution. ? When the lesion is sufficiently raised, submucosal dissection is performed using a dual knife. ? Retrieve the resected specimen, fix it on a styrofoam fixing plate, and ask the pathology department for tissue analysis. (2) onestep knife + Traction ESD (intermediate group) ? Insert the colonoscope with the transparent cap attached. ? After puncturing the submucosal layer immediately around the lesion with a puncture needle for submucosal solution injection, inject the saline-based submucosal solution. ? When the lesion is sufficiently raised, submucosal dissection is performed using a dual knife. ? When performing ESD, make an incision around the lesion. After fixing the rubber band to the endoscope clip from the outside of the patient, insert it into the channel of the colonoscope and fix the clip at the end of the pre-incision lesion using the clip. Using the second clip, hold the rubber band secured to the pre-fastened first clip and secure the clip in a position that will provide adequate traction. ? Implement additional ESD. ? Retrieve the resected specimen and fix it on a styrofoam fixing plate, and then ask the pathology department for tissue analysis Primary outcome(s): procedure time; resection speed Primary Purpose : Treatment, Intervention Model : Parallel, Blinding/Masking : Single, Blinding Target : Subject, Allocation : RCT

| 2514694 | ecrin-mdr-crc

Full Thickness Resection or Endoscopic Submucosal Dissection for Difficult Colorectal Lesions.

Project description:Compare the efficacy and safety of endoscopic resection a full thickness (EFTR) with Full Thickness Resection Device (FTRD) System versus endoscopic submucosal dissection (ESD) in the treatment of Laterally Spreading Tumor Non Granular Type (LST-NG), "no lift" lesions colon and residual / relapse on scars from previous resections endoscopic colon. The dimensional cut off of these lesions is ≤30mm

| 2745298 | ecrin-mdr-crc

A randomized controlled trial on the usefulness of underwater endoscopic submucosal dissection (ESD) versus conventional ESD for colorectal tumors

Project description:Interventions: Underwater ESD group Conventional ESD group Primary outcome(s): Dissection speed Study Design: Parallel Randomized

| 2653414 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data