Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
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ABSTRACT: This is a Phase II, open label, single-arm trial study of adding hydroxychloroquine to encorafenib and cetuximab in patients with metastatic BRAF V600E colon cancer with progression on at least 1 prior line of therapy. We hypothesize that autophagy is a major mechanism of resistance to BRAF inhibition in stage IV BRAF V600E colorectal cancer, and that the addition of hydroxychloroquine to standard encorafenib and cetuximab therapy will help overcome this resistance.
DISEASE(S): Colorectal Cancer Stage Iv,Stage Iv Colorectal Cancer Positive For Braf V600e Mutation,Colorectal Cancer,Colorectal Neoplasms
PROVIDER: 2751167 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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