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The construction and application of a mHealth-Based personalized exercise and dietary intervention for colorectal cancer survivors with fatigue

ABSTRACT: Interventions: Experimental group1:mHealth-Based exercise intervention;Control group1:Usual health education about physical activity;Experimental group2:mHealth-Based dietary intervention;Control group2:Usual health education about nutrition Primary outcome(s): fatigue Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2759687 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Expression data from mouse fetal and adult intestinal organoid cultures and intestinal tissues

Project description:Here we profiled fetal intestinal epithlelium derived organoids at day 3 (group1) and 30 (group2) of culture, adult orgnanoids at day 3 (group3) and 30 (group4) of culture and whole intestinal tissues at P0(group5) and adult (group6).

2018-12-01 | GSE118982 | GEO

High grade neuroendocrine lung cancer expression profile

Project description:Genomic gains and losses, particularly amplification of oncogenes and deletion of tumor suppressor genes, are critical molecular events involved in tumorigenesis and cancer progression. These genomic structural abnormalities trigger pathway alterations which activate/inactivate transcription factors along protein network, and then affect gene transcription profiles. Therefore, trace-back analysis of the pathway alteration by integrating genomic copy number, transcription profile, and known protein network data is expected to provide key information to interpret tumorigenesis and cancer progression processes. However, there are a number of pathway alteration candidates, so that it is difficult to understand overall picture. Primitive approaches such as filtering by arbitrary selection of thresholds involve a risk of overlooking important pathway alterations and their triggers. We proposed a visualization method for the trace-back analysis of pathway alterations, called a Cluster Overlap Distribution Map (CODM). We applied the CODM to trace-back analysis of pathway alterations related to subtype classifications of high grade neuroendocrine carcinoma samples; 1) small cell lung carcinoma (SCLC) vs. large cell neuroendocrine carcinoma (LCNEC), and 2) group1 vs. group2 (this is the classification based on transcription profiles and group2 has a higher survival rate than group1). By effective use of 3D and color spaces, the CODM allowed us to understand the overall picture of pathway alteration without arbitrary selection of thresholds and to extract 6 pathway alterations related to only group1 vs. groups2, 2 pathway alterations related to only SCLC vs. LCNEC, and 2 pathway alterations related to both group1 vs. group2 and SCLC vs. LCNEC. Keywords: lung cancer profile

2022-04-01 | GSE9074 | GEO

PRMT1-mediated FLT3 arginine methylation promotes FLT3-ITD+ Acute Myeloid Leukemia maintenance

Project description:We want to obtain FLT3-ITD gene signature. To do so, we transduced CB CD34+ cells with mock or FLT3-ITD vectors and performed RNA sequencing (RNA-Seq). Two Groups: Group1: CB CD34+ cells transduced with mock vector; Group2: CB CD34+ cells transduced with FLT3-ITD vector;

2020-04-01 | GSE129754 | GEO

Bilateral anterior quadratus lumborum block at lateral supra-arcuate ligament versus bilateral lateral quadratus lumborum block for analgesia in laparoscopic resection of colorectal cancer

Project description:Interventions: Experimental group1:Bilateral anterior quadratus lumborum block at lateral supra-arcuate ligament;Experimental group2:bilateral lateral quadratus lumborum block Primary outcome(s): the total consumption of sufentanil in 24 hours Study Design: Parallel

| 2760239 | ecrin-mdr-crc

Study on the effect of preoperative oral branched chain amino acids on postoperative insulin resistance in patients with colorectal cancer

Project description:Interventions: Control group:Drink pure water before surgery;Experimental group1:Drink low-dose BCAA before surgery;Experimental group2:Drink high-dose BCAA before surgery Primary outcome(s): Postoperative blood glucose level Study Design: Parallel

| 2760516 | ecrin-mdr-crc

Acne flare-up in treatment process: investigating the difference of gene expression in peripheral blood

Project description:Objectives: To identify gene expression changes in acne flare-up patients, thereby exploring the mechanisms of acne flare-up after treatment. Methods: 11 acne patients and 3 healthy people were divided into 4 groups (group1: 4 with flare-up, group2: 4 with improvement, group3: 3 without obvious changes, group4: healthy control). Peripheral blood of patients before and after isotretinoin or minocycline were collected. RNA-seq were used to detect the gene expression. We applied data in self-contrast and intergroup comparisons. Results: In the self-contrast of group1, 22 upregulated genes were involved in Toll-like receptor signaling pathway and inflammatory response. Comparing group1 and group3 before treatment, 1778 upregulated genes enriched in Th17 cell differentiation, while 57 downregulated genes enriched in defensive response to organism. Conclusions: The gene expression profiles of acne flare-up patients changed. Inflammatory, immune responses played a prominent role in acne flare-up process and relatively weak defensive response to microbes, comedogenesis might be risk factors.

2018-12-27 | GSE124389 | GEO

Testing Solution Focused Therapy to Decrease Fatigue Among Colorectal Cancer Patients: a randomized controlled trial

Project description:Interventions: experimental group:solution focused therapy;control group:usual health education Primary outcome(s): Cancer Raleted Fatigue Study Design: Parallel

| 2683208 | ecrin-mdr-crc

To investigate whether probiotics can delay the development of paraneoplastic thrombocythemia in patients with ovarian cancer through their effects on intestinal flora

Project description:Interventions: Group1:Bifidobacterium longum;Group2:Placebo Primary outcome(s): platelets;Fecal flora Study Design: Parallel

| 83985 | ecrin-mdr-crc

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function [microarray expression profiling]

Project description:Improved understanding of mechanisms regulating myelodysplastic syndrome (MDS) hematopoietic stem/progenitor cell (HSPC) growth and self-renewal is critical for developing MDS therapy. We revealed a novel regulatory axis that SIRT1-deficiency induced TET2 hyperacetylation promotes MDS HSPC functions, and provide an approach to target MDS HSPCs by activating SIRT1 deacetylase. Four Groups: Group1: MDS-L cells transduced with lentiviral vector targeting non-silence squence (control shRNA for SIRT1); Group2: MDS-L cells transduced with lentiviral vector containing interference squence targeting SIRT1 (SIRT shRNA); Group 3: MDS-L cells transduced with lentiviral vector targeting non-silence squence (control shRNA for TET2); Group 4: MDS-L cells transduced with lentiviral vector containing interference squence targeting TET2 (TET2 shRNA).

2018-08-13 | GSE117272 | GEO

Views on Cancer Prevention and Daily Lifestyle

Project description:This study is to assess how a theoretically guided mHealth communication informed by evidence of thoughts and affect about colorectal cancer can enhance how an existing mHealth (cell/mobile based text messaging health promotion) intervention increased physical activity in healthy adults.

| 2276764 | ecrin-mdr-crc

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