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Effects of transcutaneous electrical acupoint stimulation (TEAS) on different types of pain after laparoscopic radical colorectal resection: a randomized controlled clinical trial

ABSTRACT: Interventions: TEAS group:Effect of Transcutaneous Electrical Acupoint Stimulation;Control group:None Primary outcome(s): Postoperation pain Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2760091 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effects of percutaneous electrical acupoint stimulation on the recovery of gastrointestinal function after laparoscopic colon cancer surgery

Project description:Interventions: Control group:None;TEAS group:Transcutaneous electrical acupoint stimulation (TEAS) Primary outcome(s): Serum gastrin concentration Study Design: Parallel

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Effect of percutaneous electrical stimulation of acupuncture points on perioperative protein levels in patients with colorectal cancer

Project description:Interventions: Transcutaneous electrical acupoint stimulation group :Transcutaneous electrical stimulation was given at the bilateral Hegu, Neiguan, Feet Three Miles, Upper Juxu, Lower Juxu, and Sanyinjiao points 1 day before, during, and 1, 2, and 3 days after surgery, respectively ;False stimulus group :The electrode pads were selected to be attached at the same acupuncture points as in group A, but not energized, i.e., no current stimulation was given to the patients. Primary outcome(s): Changes in protein-related indexes (total protein, albumin, prealbumin, transferrin) at 1, 3 and 7 days postoperatively Study Design: Parallel

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Study on the effect and mechanism of percutaneous acupoint nerve electrical stimulation in postoperative cognitive dysfunction

Project description:Interventions: Group TEAS:percutaneous acupoint nerve electrical stimulation;Group CON:nothing Primary outcome(s): MMSE, Mini-mental State Examination;QoR-40, 40-Item Quality of Restoration;cortisol;noradrenaline;D-LAC;DAO Study Design: Parallel

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Smart-seq2 of spinal cord motoneurons in spinal cord injury model after dual electrical stimulation with specific frequencies

Project description:Electrical stimulation can augment or modify neuronal function and can have therapeutic benefits for certain neurological disorders. There is evidence that enhancing spinal excitability with either epidural or transcutaneous stimulation can restore some volitional motor output after spinal cord injury (SCI). Lumbosacral epidural stimulation temporarily improves locomotor and autonomic function in both rodents and humans with SCI. When combined with overground locomotor training enabled by a weight-supporting device, epidural electrical stimulation (EES) promotes extensive reorganization of residual neural pathways that improves locomotion after stopping stimulation. However, the exact mechanism underlying the reconstruction of spinal cord neural circuits with electrical stimulation is not yet known. Thus, we developed a epidural electrical and muscle stimulation(EEMS) system at the interface of the spinal cord and muscle to mimic feedforward and feedback electrical signals in spinal sensorimotor circuits. Using methods of motor function evaluation, neural circuit tracing and neural signal recording, we discovered a unique stimulus frequency of 10-20 Hz under EEMS conditions that was required for structural and functional reconstruction of spinal sensorimotor circuits. Single-cell transcriptome analysis of EEMS activated motoneurons characterized molecular networks involved in spinal sensorimotor circuit reconstruction. This study provides insights into neural signal decoding during spinal sensorimotor circuit reconstruction, and indicates a technological approach for the clinical treatment of SCI.

2023-12-05 | GSE243038 | GEO

Electrical stimulation of human embryonic stem cell derived cardiomyocytes

Project description:Analysis of the effect of electrical field stimulation frequency at the gene expression level. Electrical stimulation has been shown to mature nascent cardiomyocytes and alter their beating properties. The purpose of the array was to identify potential mediators of these effects. Total RNA was isolated from cardiomyocytes subjected to 0.5 Hz, 1 Hz, or 2 Hz continuous electrical stimulation for 7 days, compared to an unstimulated control. Three samples from each group were analyzed

2015-11-05 | E-GEOD-74669 | biostudies-arrayexpress

Human primary myotubes +/- electrical pulse stimulation

Project description:Human primary myotubes +/- electrical pulse stimulation

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Effect of preoperative acupoint electroacupuncture stimulation on postoperative recovery of patients undergoing radical colorectal cancer

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Electrical stimulation of human embryonic stem cell derived cardiomyocytes

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Home-based transcutaneous electrical acupoint stimulation for hypertension: a randomized controlled pilot trial.

Project description:The aim of this trial was to evaluate the feasibility and effect of home-based transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension. In this randomized pilot trial, patients with hypertension were randomly assigned to the TEAS group or the usual care group. Participants in the usual care group were instructed to continue taking their antihypertensive drugs and received education on lifestyle modifications. In addition, participants in the TEAS group received 4 weekly sessions of noninvasive acupoint stimulation for 12 weeks at home. The primary outcome was the change in office systolic blood pressure at week 12 from baseline. Withdrawal from the study and adverse events associated with TEAS were also recorded. Sixty patients were randomized, with 30 patients in the TEAS group, of whom 1 was lost at week 36, and 30 patients in the usual care group, of whom 3 were lost by week 12. The reduction in systolic blood pressure at week 12 was greater in the TEAS group (-8.53 mm Hg; 95% CI [-13.37, -3.70 mm Hg]) than in the usual care group (-1.70 mm Hg; 95% CI [-4.29, -0.89 mm Hg]), with a between-group difference of -6.83 mm Hg (95% CI, [-12.23, -1.43 mm Hg]; P = 0.014). No TEAS-related adverse events occurred. In conclusion, home-based TEAS added to usual care for patients with hypertension was acceptable and safe and may be a potential treatment option. A larger randomized controlled trial of this intervention is warranted.

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Redefining electrical stimulation safety using spatial transcriptomics

Project description:Redefining electrical stimulation safety using spatial transcriptomics

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