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KEEP-G06A prospective, open, single-center, single-arm phase II study of Sintilimab combined with Fruquintinib and Fecal Microbiota Transplantation(FMT) in the treatment of Non-MSI-H/dMMR advanced colorectal cancer

ABSTRACT: Interventions: experimental group:Sintilimab combined with Fruquintinib and Fecal Microbiota Transplantation(FMT) Primary outcome(s): ORR Study Design: Single arm

DISEASE(S): Colorectal Cancer

PROVIDER: 36777 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation

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Neoadjuvant treatment of sintilimab plus hypofractionated radiotherapy for MSI-H/dMMR rectal cancer: A prospective, multicenter, phase Ib study.

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Project description:This study aimed to analyze changes in gut microbiota composition in mice after transplantation of fecal microbiota (FMT, N = 6) from the feces of NSCLC patients by analyzing fecal content using 16S rRNA sequencing, 10 days after transplantation. Specific-pathogen-free (SPF) mice were used for each experiments (N=4) as controls.

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